1999-08 to 2005-04 Postdoctoral: Oregon Health & Science University
1994-08 to 1999-06 PhD in Pharmacology: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
1990-08 to 1994-07 Bachelor's in Microbiology: Shandong University
2015-05 to Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher, Group Leader, Doctoral Supervisor
2009-03 to 2015-05 - Eli Lilly and Company Biotechnology Drug Discovery Center - Senior Research Scientist
2005-04 to 2009-03 - Oregon Health & Science University - Assistant Professor
John Whitaker Multiple Sclerosis Young Investigator Award (2009): First Prize
John Whitaker Multiple Sclerosis Young Investigator Award (2006): First Prize
Chinese Academy of Sciences President's Scholarship (1999): First Prize
Research
Discovery, screening, and engineering of monoclonal and bispecific antibody drug molecules Modification of linkers in novel antibody-drug conjugates (ADCs)
Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities, Chunhe Wang, 2023
Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster, Chunhe Wang, 2023
Chemotherapy-Induced Peripheral Neuropathy Is Alleviated by NGF Monoclonal Antibody, Chunhe Wang, 2022
Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain, Chunhe Wang, 2022
HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities, Chunhe Wang, 2022
Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model, Chunhe Wang, 2022
First-in-human study to assess the safety, tolerability, pharmacokinetics and immunogenicity of DS002, an anti-nerve growth factor monoclonal antibody, Chunhe Wang, 2022
Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs, Chunhe Wang, 2022
TROP2 as Patient-Tailoring but Not Prognostic Biomarker for Breast Cancer, Chunhe Wang, 2022
Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera, Chunhe Wang, 2021
Progress of antibody therapeutics in the treatment of psoriasis, Chunhe Wang, 2021
ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker, Chunhe Wang, 2021
A bispecific antibody targeting HER2 and PD-L1 inhibits tumor growth with superior efficacy, Chunhe Wang, 2021
Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index, Chunhe Wang, 2020
Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells, Chunhe Wang, 2011
Down-Modulation of Programmed Death 1 Alters Regulatory T Cells and Promotes Experimental Autoimmune Encephalomyelitis, Chunhe Wang, 2010
Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1, Chunhe Wang, 2009
Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1, Chunhe Wang, 2009
Recombinant T-cell Receptor Ligands: Immunomodulatory, Neuroprotective and Neuroregenerative Effects Suggest Application as Therapy for Multiple Sclerosis, Chunhe Wang, 2008
GPR30 contributes to estrogen-induced thymic atrophy, Chunhe Wang, 2008
Antigen-Specific Therapy Promotes Repair of Myelin and Axonal Damage in Established EAE, Chunhe Wang, 2006
αB-Crystallin-reactive T cells from knockout mice are not encephalitogenic, Chunhe Wang, 2006
Treatment of passive EAE in SJL mice with a recombinant TCR ligand induces high levels of IL-13., Chunhe Wang, 2005
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases, Chunhe Wang, 2005
CD4 T-cell epitopes of human alpha B-crystallin, Chunhe Wang, 2004
Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation, Chunhe Wang, 2003
Recombinant TCR Ligand Induces Tolerance to Myelin Oligodendrocyte Glycoprotein 35-55 Peptide and Reverses Clinical and Histological Signs of Chronic Experimental Autoimmune Encephalomyelitis in HLA-DR2 Transgenic Mice, Chunhe Wang, 2003
Rudimentary TCR Signaling Triggers Default IL-10 Secretion by Human Th1 Cells, Chunhe Wang, 2001
Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells, Chunhe Wang, 1999
The C-truncated delta-opioid receptor underwent agonist-dependent activation and desensitization, Chunhe Wang, 1998
Human mu-opioid receptor overexpressed in baculovirus system and its pharmacological characterizations, Chunhe Wang, 1998
The carboxyl terminus mouse delta-opioid receptor is not required for agonist-dependent activation., Chunhe Wang, 1997
Area of Focus
Marine Microbiology | Drug Discovery | Pharmacology | Preclinical Research | Anti-Tumor | Medicinal Chemistry | Natural Products | Drug Resistance | Pharmacokinetics | Mechanism Of Action
