Areas of Focus
- Immunology - Metabolism and Immunity
- Cell Biology - Tissue Stem Cells and Microenvironment
Work Experience
- 2020-04~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - Researcher/Group Leader
- 2015-12~2020-03 - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Researcher
- 2011-11~2015-11 - Chinese Academy of Sciences, Shanghai Institute of Life Sciences - Associate Researcher
- 2009-11~2011-06 - University of Münster, Germany - Postdoctoral Researcher
Academic Background & Achievements
- 2006-09--2009-06 PhD: Shanghai Jiao Tong University
- 2003-08--2006-06 Master's Degree: Shanghai Jiao Tong University
Publications
- Oleic acid availability impacts thymocyte preprogramming and subsequent peripheral Treg cell differentiation., Nature Immunology, 2024
- Characteristic and fate determination of adipose precursors during adipose tissue remodeling., Cell Regeneration, 2023
- MHC class Ib-restricted CD8+ T cells possess strong tumoricidal activities., Proc Natl Acad Sci U S A., 2023
- Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer., Nature Metabolism, 2023
- SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes., Advanced Science, 2023
- Reciprocal regulation of mesenchymal stem cells and immune responses., Cell Stem Cell, 2022
- Mesenchymal stromal cells equipped by IFN empower T cells with potent anti-tumor immunity., Oncogene, 2022
- Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells., Theranostics, 2022
- Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin., Cell Death and Differentiation, 2021
- Syncytia formation during SARS-CoV-2 lung infection: a disastrous unity to eliminate lymphocytes., Cell Death and Differentiation, 2021
- Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3, Nature Communications, 2021
- Steroids enable mesenchymal stromal cells to promote CD8+T cell proliferation via VEGF-C., Advanced Science, 2021
- IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages., Science Advances, 2020
- Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Proc Natl Acad Sci U S A., 2020
- COVID-19 infection: the perspectives on immune responses, Cell Death & Differentiation, 2020
- Mesenchymal stromal cells pretreated with pro-inflammatory cytokines promote skin wound healing through VEGFC-mediated angiogenesis, STEM CELLS TRANSLATIONAL MEDICINE, 2020
- Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals, CELL AND BIOSCIENCE, 2020
- The endothelial basement membrane - a check point for entry of pathogenic T cells into the brain., Journal of Experimental Medicine., 2020
- IGF-2 preprograms maturing macrophages to acquire oxidative phosphorylation-dependent anti-inflammatory properties, EUROPEAN JOURNAL OF IMMUNOLOGY, 2019
- Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development, CELL DEATH AND DISEASE, 2019
- Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity, CELL DEATH AND DISEASE, 2019
- IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-dependent Anti-inflammatory Properties., Cell Metabolism, 2019
- Immune Regulatory Mechanisms of Mesenchymal Stem Cells., Nature Reviews Nephrology, 2018
- Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGF Promotes Breast Cancer Metastasis., Oncogene, 2017
- TNF-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils., Oncogene, 2017
- Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets, NATURE REVIEWS DRUG DISCOVERY, 2017
- Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?, CELL DEATH AND DIFFERENTIATION, 2016
- Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells, ONCOGENE, 2016
- Local proliferation initiates macrophage accumulation in adipose tissue during obesity, CELL DEATH & DISEASE, 2016
- Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities, ONCOGENE, 2016
- SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation, CELL REPORTS, 2016
- CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015
- Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity, ONCOGENE, 2015
- Rethinking regeneration: empowerment of stem cells by inflammation, CELL DEATH AND DIFFERENTIATION, 2015
- Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications, NATURE IMMUNOLOGY, 2014
Awards
- National 'Ten Thousand Talents Program' Young Top-notch Talent (2020): National Level
- Young Researcher Award, Chinese Society for Cell Biology Stem Cell Biology Branch (2019): Other
- Outstanding Member, Youth Innovation Promotion Association, Chinese Academy of Sciences (2017): Institute Level
- Shanghai Youth Science and Technology Star (2014): Municipal Level
