Xiaoli Xiong
xiong_xiaoli@gibh.ac.cn
English, Chinese
Guangdong
University of Chinese Academy of Sciences
Medical School
  • 2007-10--2011-07 PhD: University of Bristol
  • 2004-10--2007-07 BSc (Hons): University of Bristol
  • 2020-08~Present - Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health - Researcher
  • 2018-05~2020-08 - MRC Laboratory of Molecular Biology - Postdoctoral Scientist
  • 2016-10~2018-04 - University of Washington - Senior Fellow
  • 2015-01~2016-09 - The Francis Crick Institute - Career Development Fellow
  • 2011-03~2014-12 - MRC National Institute for Medical Research - Career Development Fellow
Macromolecular Structure
Influenza Virus
Coronavirus
  • Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvirnull, Xiaoli Xiong, 2024
  • Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants, Haisheng Yu, Banghui Liu, Yudi Zhang, Xijie Gao, Qian Wang, Haitao Xiang, Xiaofang Peng, Caixia Xie, Yaping Wang, Peiyu Hu, Jingrong Shi, Quan Shi, Pingqian Zheng, Chengqian Feng, Guofang Tang, Xiaopan Liu, Liliangzi Guo, Xiumei Lin, Jiaojiao Li, Chuanyu Liu, Yaling Huang, Naibo Yang, Qiuluan Chen, Zimu Li, Mengzhen Su, Qihong Yan, Rongjuan Pei, Xinwen Chen, Longqi Liu, Fengyu Hu, Dan Liang, Bixia Ke, Changwen Ke, Feng Li, Jun He, Meiniang Wang, Ling Chen, Xiaoli Xiong, Xiaoping Tang, 2023
  • Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies, MiaoMiao Zhao, Yun Zhu, Li Zhang, Gongxun Zhong, Linhua Tai, Shuo Liu, Guoliang Yin, Jing Lu, Qiong He, MingJia Li, RuXuan Zhao, Hao Wang, Weijin Huang, Changfa Fan, Lei Shuai, Zhiyuan Wen, Chong Wang, Xijun He, Qiuluan Chen, Banghui Liu, Xiaoli Xiong, Zhigao Bu, Youchun Wang, Fei Sun, JinKui Yang, 2022
  • SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope, Ping He, Banghui Liu, Xijie Gao, Qihong Yan, Rongjuan Pei, Jing Sun, Qiuluan Chen, Ruitian Hou, Zimu Li, Yanjun Zhang, Jincun Zhao, Hao Sun, Bo Feng, Qian Wang, Haisu Yi, Peiyu Hu, Pingchao Li, Yudi Zhang, Zhilong Chen, Xuefeng Niu, Xiaolin Zhong, Liang Jin, Xiaofeng Liu, Kun Qu, Katarzyna A Ciazynska, Andrew P Carter, John A G Briggs, Jizheng Chen, Jinsong Liu, Xinwen Chen, Jun He, Ling Chen, Xiaoli Xiong, 2022
  • Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants, Qihong Yan, Ruitian Hou, Xiaohan Huang, Yanjun Zhang, Ping He, Yudi Zhang, Banghui Liu, Qian Wang, Haiyue Rao, Xianying Chen, Xinwei Zhao, Xuefeng Niu, Jincun Zhao, Xiaoli Xiong, Ling Chen, 2022
  • A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape, Bo Feng, Zhilong Chen, Jing Sun, Tingting Xu, Qian Wang, Haisu Yi, Xuefeng Niu, Jiabin Zhu, Mengzhu Fan, Ruitian Hou, Ying Shao, Sihui Huang, Cuiyun Li, Peiyu Hu, Pingqian Zheng, Ping He, Jia Luo, Qihong Yan, Xiaoli Xiong, Jinsong Liu, Jincun Zhao, Ling Chen, 2022
  • Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike, Kun Qu, Qiuluan Chen, Katarzyna A Ciazynska, Banghui Liu, Xixi Zhang, Jingjing Wang, Yujie He, Jiali Guan, Jun He, Tian Liu, Xiaofei Zhang, Andrew P Carter, Xiaoli Xiong, John A G Briggs, 2022
  • New structural insights into the multifunctional influenza A matrix protein 1, Julia Peukes, Xiaoli Xiong, John A G Briggs, 2021
  • Hemagglutinin Structure and Activities, Steven J Gamblin, Sebastien G Vachieri, Xiaoli Xiong, Jie Zhang, Stephen R Martin, John J Skehel, 2021
  • Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients, Qihong Yan, Ping He, Xiaohan Huang, Kun Luo, Yudi Zhang, Haisu Yi, Qian Wang, Feng Li, Ruitian Hou, Xiaodi Fan, Pingchao Li, Xinglong Liu, Huan Liang, Yijun Deng, Zhaoming Chen, Yunfei Chen, Xiaoneng Mo, Liqiang Feng, Xiaoli Xiong, Song Li, Jian Han, Linbing Qu, Xuefeng Niu, Ling Chen, 2021
  • SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses, George W Carnell, Katarzyna A Ciazynska, David A Wells, Xiaoli Xiong, Ernest T Aguinam, Stephen H McLaughlin, Donna Mallery, Soraya Ebrahimi, Lourdes CeronGutierrez, Benedikt Asbach, Sebastian Einhauser, Ralf Wagner, Leo C James, Rainer Doffinger, Jonathan L Heeney, John A G Briggs, 2021
  • Structural basis for broad coronavirus neutralization, Maximilian M Sauer, M Alejandra Tortorici, YoungJun Park, Alexandra C Walls, Leah Homad, Oliver J Acton, John E Bowen, Chunyan Wang, Xiaoli Xiong, Willem de van der Schueren, Joel Quispe, Benjamin G Hoffstrom, BerendJan Bosch, Andrew T McGuire, David Veesler, 2021
  • Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-patient Facing Staff in First Wave of COVID19, Helen E Baxendale, David Wells, Jessica Gronlund, Angalee Nadesalingham, Mina Paloniemi, George Carnell, Paul Tonks, Lourdes CeronGutierrez, Soraya Ebrahimi, Ashleigh Sayer, John AG Briggs, Xiaoli Ziong, James A Nathan, Guinevere Grice, Leo C James, Jakub Luptak, Sumita Pai, Jonathan L Heeney, Sara Lear, Rainer Doffinger, 2021
  • Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals, Sander Herfst, Jie Zhang, Mathilde Richard, Ryan McBride, Pascal Lexmond, Theo M Bestebroer, Monique I J Spronken, Dennis de Meulder, Judith M van den Brand, Miruna E Rosu, Stephen R Martin, Steve J Gamblin, Xiaoli Xiong, Wenjie Peng, Rogier Bodewes, Erhard van der Vries, Albert D M E Osterhaus, James C Paulson, John J Skehel, Ron A M Fouchier, 2020
  • Structures and distributions of SARS-CoV-2 spike proteins on intact virions, Zunlong Ke, Joaquin Oton, Kun Qu, Mirko Cortese, Vojtech Zila, Lesley McKeane, Takanori Nakane, Jasenko Zivanov, Christopher J Neufeldt, Berati Cerikan, John M Lu, Julia Peukes, Xiaoli Xiong, HansGeorg Krausslich, Sjors H W Scheres, Ralf Bartenschlager, John A G Briggs, 2020
  • Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals, Allen Zheng, Weina Sun, Xiaoli Xiong, Alec W Freyn, Julia Peukes, Shirin Strohmeier, Raffael Nachbagauer, John A G Briggs, Florian Krammer, Peter Palese, 2020
  • A thermostable, closed SARS-CoV-2 spike protein trimer, Xiaoli Xiong, Kun Qu, Katarzyna A Ciazynska, Myra Hosmillo, Andrew P Carter, Soraya Ebrahimi, Zunlong Ke, Sjors H W Scheres, Laura Bergamaschi, Guinevere L Grice, Ying Zhang, James A Nathan, Stephen Baker, Leo C James, Helen E Baxendale, Ian Goodfellow, Rainer Doffinger, John A G Briggs, John Bradley, Paul A Lyons, Kenneth G C Smith, Mark Toshner, Anne Elmer, Carla Ribeiro, Jenny Kourampa, Sherly Jose, Jane Kennet, Jane Rowlands, Anne Meadows, Criona OBrien, Rebecca Rastall, Cherry Crucusio, Sarah Hewitt, Jane Price, Jo Calder, Laura Canna, Ashlea Bucke, Hugo Tordesillas, Julie Harris, Valentina Ruffolo, Jason Domingo, Barbara Graves, Helen Butcher, Daniela Caputo, Emma Le Gresley, Benjamin J Dunmore, Jennifer Martin, Ekaterina Legchenko, Carmen Treacy, Christopher Huang, Jennifer Wood, Rachel Sutcliffe, Josh Hodgson, Joy Shih, Stefan Graf, Zhen Tong, Federica Mescia, Tobias Tilly, Ciara ODonnell, Kelvin Hunter, Linda Pointon, Nicole Pond, Marta Wylot, Emma Jones, Stuart Fawke, Ben Bul, 2020
  • Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant, Petra Mlcochova, Dami Collier, Allyson Ritchie, Sonny M Assennato, Myra Hosmillo, Neha Goel, Bo Meng, Krishna Chatterjee, Vivien Mendoza, Nigel Temperton, Leo Kiss, Leo C James, Katarzyna A Ciazynska, Xiaoli Xiong, John A G Briggs, James A Nathan, Federica Mescia, Laura Bergamaschi, Hongyi Zhang, Petros Barmpounakis, Nikos Demeris, Richard Skells, Paul A Lyons, John Bradley, Steven Baker, Jean Pierre Allain, Kenneth G C Smith, Rachel Bousfield, Michael Wilson, Dominic Sparkes, Glenn Amoroso, Effrosyni GkraniaKlotsas, Susie Hardwick, Adrian Boyle,
Macromolecular Structure: Protein Structure Biochemistry Molecular Biology Macromolecule Crystallography Nmr Spectroscopy Modeling Analysis Influenza Virus: Flu Virus Infection Hemagglutinin Neuraminidase Vaccine Pandemic Transmission Immunity Antiviral Coronavirus: Sars-Cov-2 Covid-19 Spike Protein Mutation

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