Areas of Focus
- Transcriptional regulation mechanisms in higher biological developmental processes
- Transcriptional regulation mechanisms in mammalian early embryonic development
- Transcriptional regulation mechanisms in mammalian stem cell differentiation and pluripotency maintenance
Work Experience
- 2018 - Fudan University Affiliated Cancer Hospital: Postdoctoral Research
- 2023 - Tongji University School of Life Sciences and Technology: Distinguished Research Fellow, Dual-appointed Professor at Shanghai Fourth People's Hospital
Academic Background & Achievements
- 2018 - PhD in Science: Shanghai Jiao Tong University School of Medicine
- Received 'Super' Postdoctoral Award from Fudan University
Publications
- R-loop-dependent promoter-proximal termination ensures genome stability, Xu C, Li C, Chen J, Xiong Y, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX, 2023
- Stabilization of Integrator/INTAC by the small but versatile DSS1 protein, Xu C, Zhou QX, Zheng H, Song A, Zhao WY, Xiong Y, Huang Z, Xu Y, Cheng J, Chen FX, 2024
- From snapshots to a movie: Capturing eukaryotic transcription initiation at single-nucleotide resolution, Shang XY, Xu C, Chen FX, 2024
- Catalytic-independent functions of INTAC in conferring sensitivity to BET inhibition, Fan P, Shang XY, Song A, Chen S, Mao RY, Chen J, Wang Z, Zheng H, Tao B, Xu W, Jiang W, Yang H, Xu C, Zhang P, Jiang H, Chen FX, 2024
- Mechanisms of SOSS-Integrator-PP2A complex in attenuating R-loops and promoting genome stability, Wang J, Xu C, Zhang Z, Chen FX, 2024
- SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape, Hu S, Peng L, Xu C, Wang Z, Song A, Chen FX, 2021
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y, 2020
- Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer, Xu C, Wang X, Zhou Y, et al., 2019
- Comprehensive epigenetic analyses reveal master regulators driving lung metastasis of breast cancer, Li K, Xu C, Du Y, Junaid M, Kaushik AC, Wei DQ, 2019
- KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα, Wang X, Fan H, Xu C, et al., 2019
- Cooperativity of co-factor NR2F2 with Pioneer Factors GATA3, FOXA1 in promoting ERα function, Jiang G, Wang X, Sheng D, Zhou L, Liu Y, Xu C, et al., 2019
- Shared genetic and epigenetic mechanisms between chronic periodontitis and oral squamous cell carcinoma, Li S, Liu X, Zhou Y, Acharya A, Savkovic V, Xu C, et al., 2018
Awards
- Outstanding Award from the Biophysical Society of China Women's Science Forum
