2015-09--2018-06 Ph.D.: University of Chinese Academy of Sciences (Kunming Institute of Botany and Shanghai Institute of Organic Chemistry)
2012-09--2015-06 Master's: University of Chinese Academy of Sciences, Kunming Institute of Botany
2008-09--2012-07 Bachelor's: Shenyang Pharmaceutical University
Completed the first chemical synthesis of 12 natural terpenoid molecules with 6 different skeletons
Published over 30 SCI papers, including 14 as first/co-first/corresponding author
2022-03 - Present - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher, Introduced Talent
2020-02 - 2022-02 - Kunming Institute of Botany, Chinese Academy of Sciences - Postdoctoral Researcher
2018-07 - 2020-01 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher
Yunnan Province Outstanding Youth Fund (2024)
Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2023)
Yunnan Province 'Xingdian Talent Support Program' Young Talent (2023)
Yunnan Province Postdoctoral Research Fund Outstanding Achievement First Prize (2021)
Research
Efficient synthesis of active terpenoid natural products guided by new strategies and methods Discovery of lead compounds for natural drugs through interdisciplinary research involving chemical biology and artificial intelligence
Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol, 7th Author, 2024
Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating 4 + 2 cycloaddition and target differentiation of enantiomers, 2nd Author, 2023
Cyclobutane-containing meroditerpenoids, (+)-isoscopariusins B and C: structure elucidation and biomimetic synthesis, 2nd Author, 2023
Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function, Corresponding Author, 2023
Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues, 2nd Author, 2023
Scopariusicides D-M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused gamma/delta-lactone core from Isodon scoparius, 3rd Author, 2022
Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling, 4th Author, 2022
Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities, 1st Author, 2022
Isolation and Bioinspired Total Synthesis of Rugosiformisin A, A Skeleton-Rearranged Abietane-Type Diterpenoid from Isodon rugosiformis, 5th Author, 2022
Structurally diverse diterpenoids from Isodon oresbius and their bioactivity, Corresponding Author, 2022
Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities, 1st Author, 2022
Harnessing natural products by a pharmacophore-oriented semisynthesis approach for the discovery of potential anti-SARS-CoV-2 agents, 2nd Author, 2022
Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis, 2nd Author, 2021
(-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis, 1st Author, 2021
High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities, 4th Author, 2021
Phomopsisins A–C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917, 5th Author, 2020
ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus, 3rd Author, 2020
4,5-Seco-18-nor-ent-clerodanoids and their derivatives: Structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans, 2nd Author, 2020
Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi, 2nd Author, 2020
Isorugosiformins A–F, six ent-kaurane diterpenoids from Isodon rugosiformis, 2nd Author, 2020
Isopenicins a-c: two types of antitumor meroterpenoids from the plant endophytic fungus penicillium sp. sh18, 6th Author, 2019
Maoeriocalysins a-d, four novel ent-kaurane diterpenoids from isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis, 3rd Author, 2019
Polyketides from the endophytic fungus Phomopsis sp. sh917 by using the one strain/many compounds strategy, 4th Author, 2017
Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry, 3rd Author, 2016
Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp shj2, 1st Author, 2016
LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18, 3rd Author, 2016
6,7-Seco-ent-kaurane-type diterpenoids from Isodon eriocalyx var.laxiflora, 2nd Author, 2014
Area of Focus
Artificial Intelligence | High-Throughput Experimentation | Automation | Machine Learning | Drug Development | Chemical Synthesis | Data Science | Molecular Design | Natural Products | Drug Molecules
