Areas of Focus
- Efficient synthesis of active terpenoid natural products guided by new strategies and methods
- Discovery of lead compounds for natural drugs through interdisciplinary research involving chemical biology and artificial intelligence
Work Experience
- 2022-03 - Present - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher, Introduced Talent
- 2020-02 - 2022-02 - Kunming Institute of Botany, Chinese Academy of Sciences - Postdoctoral Researcher
- 2018-07 - 2020-01 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2015-09--2018-06 Ph.D.: University of Chinese Academy of Sciences (Kunming Institute of Botany and Shanghai Institute of Organic Chemistry)
- 2012-09--2015-06 Master's: University of Chinese Academy of Sciences, Kunming Institute of Botany
- 2008-09--2012-07 Bachelor's: Shenyang Pharmaceutical University
- Completed the first chemical synthesis of 12 natural terpenoid molecules with 6 different skeletons
- Published over 30 SCI papers, including 14 as first/co-first/corresponding author
Publications
- Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol, 7th Author, 2024
- Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating 4 + 2 cycloaddition and target differentiation of enantiomers, 2nd Author, 2023
- Cyclobutane-containing meroditerpenoids, (+)-isoscopariusins B and C: structure elucidation and biomimetic synthesis, 2nd Author, 2023
- Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function, Corresponding Author, 2023
- Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues, 2nd Author, 2023
- Scopariusicides D-M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused gamma/delta-lactone core from Isodon scoparius, 3rd Author, 2022
- Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling, 4th Author, 2022
- Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities, 1st Author, 2022
- Isolation and Bioinspired Total Synthesis of Rugosiformisin A, A Skeleton-Rearranged Abietane-Type Diterpenoid from Isodon rugosiformis, 5th Author, 2022
- Structurally diverse diterpenoids from Isodon oresbius and their bioactivity, Corresponding Author, 2022
- Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities, 1st Author, 2022
- Harnessing natural products by a pharmacophore-oriented semisynthesis approach for the discovery of potential anti-SARS-CoV-2 agents, 2nd Author, 2022
- Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis, 2nd Author, 2021
- (-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis, 1st Author, 2021
- Tangutidines A-C,Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum, 2nd Author, 2021
- High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities, 4th Author, 2021
- Phomopsisins A–C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917, 5th Author, 2020
- ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus, 3rd Author, 2020
- 4,5-Seco-18-nor-ent-clerodanoids and their derivatives: Structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans, 2nd Author, 2020
- Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi, 2nd Author, 2020
- Isorugosiformins A–F, six ent-kaurane diterpenoids from Isodon rugosiformis, 2nd Author, 2020
- Isopenicins a-c: two types of antitumor meroterpenoids from the plant endophytic fungus penicillium sp. sh18, 6th Author, 2019
- Maoeriocalysins a-d, four novel ent-kaurane diterpenoids from isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis, 3rd Author, 2019
- Polyketides from the endophytic fungus Phomopsis sp. sh917 by using the one strain/many compounds strategy, 4th Author, 2017
- Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry, 3rd Author, 2016
- Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp shj2, 1st Author, 2016
- LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18, 3rd Author, 2016
- 6,7-Seco-ent-kaurane-type diterpenoids from Isodon eriocalyx var.laxiflora, 2nd Author, 2014
Awards
- Yunnan Province Outstanding Youth Fund (2024)
- Member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2023)
- Yunnan Province 'Xingdian Talent Support Program' Young Talent (2023)
- Yunnan Province Postdoctoral Research Fund Outstanding Achievement First Prize (2021)
