2005-09--2010-07 PhD: Kunming Institute of Botany, Chinese Academy of Sciences
2001-09--2005-07 Bachelor's: Guizhou University
2020-11~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
2015-06~2016-06 - University of North Carolina at Chapel Hill - Visiting Scholar
2014-01~2020-11 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
2010-07~2014-01 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher
Yunnan Province Natural Science First Prize (2009): R6
Guangxi Natural Science Second Prize (2021): R8
Research
Research on active alkaloids with important physiological functions, exploring their structure, activity, mechanism of action, and druggability using phytochemistry, chemical synthesis, and biology.
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit b-Amyloid42 Production and Phospho-Tau (Thr217), Yu Zhang, 2023
Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation, Yu Zhang, 2022
Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon, Yu Zhang, 2022
Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway, Yu Zhang, 2021
Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities, Yu Zhang, 2021
Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans, Yu Zhang, 2021
Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity, Yu Zhang, 2021
Isolation and structure elucidation of tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2021
Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity, Yu Zhang, 2020
Synthesis and PDE-10 Inhibition of 3-substituted Phenylimino-indolin-2-ones, Yu Zhang, 2020
Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L, Yu Zhang, 2020
Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia, Yu Zhang, 2020
Taberdivamines A and B, two new quaternary indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2020
A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud, Yu Zhang, 2020
Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Yu Zhang, 2020
Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Yu Zhang, 2020
Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis, Yu Zhang, 2020
Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity, Yu Zhang, 2020
Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2019
Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings, Yu Zhang, 2019
Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius, Yu Zhang, 2019
Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum, Yu Zhang, 2019
Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis, Yu Zhang, 2019
Fluevirines E and F, two new alkaloids from Flueggea virosa, Yu Zhang, 2019
Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities, Yu Zhang, 2019
Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new wnt/beta-catenin signalling pathway agonists, Yu Zhang, 2019
Five new alkaloids from Aconitum apetalum (Ranunculaceae), Yu Zhang, 2019
Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii, Yu Zhang, 2018
Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus, Yu Zhang, 2018
Munronin O, a potential activator for plant resistance, Yu Zhang, 2018
Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, Yu Zhang, 2018
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yu Zhang, 2018
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yu Zhang, 2018
Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis, Yu Zhang, 2018
Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis, Yu Zhang, 2018
Two new monoterpenoid indole alkaloids from Alstonia rostrata, Yu Zhang, 2018
Seven new anthranilamide derivatives from Aconitum apetalum, Yu Zhang, 2018
Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, Yu Zhang, 2018
Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens, Yu Zhang, 2018
Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation, Yu Zhang, 2017
Melohenryines A and B, two new indole alkaloids from Melodinus henryi, Yu Zhang, 2017
Keywords
Active AlkaloidsPhysiological FunctionsPhytochemistryChemical SynthesisBiologyStructureActivityMechanism Of ActionDruggabilityResearch
