Areas of Focus
- Research on active alkaloids with important physiological functions, exploring their structure, activity, mechanism of action, and druggability using phytochemistry, chemical synthesis, and biology.
Work Experience
- 2020-11~Present - Kunming Institute of Botany, Chinese Academy of Sciences - Researcher
- 2015-06~2016-06 - University of North Carolina at Chapel Hill - Visiting Scholar
- 2014-01~2020-11 - Kunming Institute of Botany, Chinese Academy of Sciences - Associate Researcher
- 2010-07~2014-01 - Kunming Institute of Botany, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2005-09--2010-07 PhD: Kunming Institute of Botany, Chinese Academy of Sciences
- 2001-09--2005-07 Bachelor's: Guizhou University
Publications
- New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit b-Amyloid42 Production and Phospho-Tau (Thr217), Yu Zhang, 2023
- Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation, Yu Zhang, 2022
- Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon, Yu Zhang, 2022
- Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway, Yu Zhang, 2021
- Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities, Yu Zhang, 2021
- Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans, Yu Zhang, 2021
- Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity, Yu Zhang, 2021
- Isolation and structure elucidation of tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2021
- Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity, Yu Zhang, 2020
- Synthesis and PDE-10 Inhibition of 3-substituted Phenylimino-indolin-2-ones, Yu Zhang, 2020
- Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L, Yu Zhang, 2020
- Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia, Yu Zhang, 2020
- Taberdivamines A and B, two new quaternary indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2020
- A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud, Yu Zhang, 2020
- Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Yu Zhang, 2020
- Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Yu Zhang, 2020
- Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis, Yu Zhang, 2020
- Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity, Yu Zhang, 2020
- Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon, Yu Zhang, 2020
- Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization, Yu Zhang, 2019
- Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata, Yu Zhang, 2019
- Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings, Yu Zhang, 2019
- Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius, Yu Zhang, 2019
- Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization, Yu Zhang, 2019
- Acoapetaludines A-K, C20 and C19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch, Yu Zhang, 2019
- Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus, Yu Zhang, 2019
- Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum, Yu Zhang, 2019
- Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis, Yu Zhang, 2019
- Fluevirines E and F, two new alkaloids from Flueggea virosa, Yu Zhang, 2019
- Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities, Yu Zhang, 2019
- Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new wnt/beta-catenin signalling pathway agonists, Yu Zhang, 2019
- Five new alkaloids from Aconitum apetalum (Ranunculaceae), Yu Zhang, 2019
- Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii, Yu Zhang, 2018
- Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus, Yu Zhang, 2018
- Munronin O, a potential activator for plant resistance, Yu Zhang, 2018
- Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, Yu Zhang, 2018
- Taburnaemines A-I, cytotoxic vobasinyl-ibogan-type bisindole alkaloids from Tabernaemontana corymbosa, Yu Zhang, 2018
- C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yu Zhang, 2018
- C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Yu Zhang, 2018
- Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis, Yu Zhang, 2018
- Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis, Yu Zhang, 2018
- Two new monoterpenoid indole alkaloids from Alstonia rostrata, Yu Zhang, 2018
- Seven new anthranilamide derivatives from Aconitum apetalum, Yu Zhang, 2018
- Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, Yu Zhang, 2018
- Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens, Yu Zhang, 2018
- Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation, Yu Zhang, 2017
- Melohenryines A and B, two new indole alkaloids from Melodinus henryi, Yu Zhang, 2017
Awards
- Yunnan Province Natural Science First Prize (2009): R6
- Guangxi Natural Science Second Prize (2021): R8
