Professor | Yuanyuan Zhang | Asia Growth Partners

Name

Yuanyuan Zhang

Contact Information

zhangyy@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2010-09 to 2015-01 PhD in Genetics: Fudan University 2000-09 to 2004-06 Bachelor's in Life Sciences: Fudan University
Work Experience	2023-09 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher 2018-09 to 2023-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher 2017-08 to 2018-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher 2015-01 to 2017-07 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher 2006-06 to 2010-08 - Fudan University National Key Laboratory of Genetic Engineering - Research Secretary 2005-06 to 2006-06 - Chinese Academy of Sciences Shanghai Institute of Nutrition Sciences - Research Assistant 2004-07 to 2005-06 - Fudan University Institute of Genetics - Research Assistant

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

Work Experience

2023-09 to Present - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Researcher
2018-09 to 2023-09 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Associate Researcher
2017-08 to 2018-08 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Assistant Researcher
2015-01 to 2017-07 - Chinese Academy of Sciences Shanghai Institute of Materia Medica - Postdoctoral Researcher
2006-06 to 2010-08 - Fudan University National Key Laboratory of Genetic Engineering - Research Secretary
2005-06 to 2006-06 - Chinese Academy of Sciences Shanghai Institute of Nutrition Sciences - Research Assistant
2004-07 to 2005-06 - Fudan University Institute of Genetics - Research Assistant

Areas of Focus	Pharmacology of Cancer and Immune Diseases Epigenetics and Metabolism Chemical Biology
Publications	Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis, 11th Author, 2022 Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis, 11th Author, 2022 L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression, 11th Author, 2022 P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K inhibitor idelalisib, 11th Author, 2022 PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma, 11th Author, 2021 Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury, 11th Author, 2021 Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, 2nd Author, 2021 Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion, 3rd Author, 2020 p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization, 11th Author, 2009

Areas of Focus

Pharmacology of Cancer and Immune Diseases
Epigenetics and Metabolism
Chemical Biology

Publications

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis, 11th Author, 2022
Selective bromodomain and extra-terminal bromodomain inhibitor inactivates macrophages and hepatic stellate cells to inhibit liver inflammation and fibrosis, 11th Author, 2022
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression, 11th Author, 2022
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K inhibitor idelalisib, 11th Author, 2022
PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma, 11th Author, 2021
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury, 11th Author, 2021
Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, 2nd Author, 2021
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion, 3rd Author, 2020
p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization, 11th Author, 2009

Cancer Immune Diseases Pharmacology Epigenetics Metabolism Chemical Biology Drug Discovery Molecular Mechanisms Therapeutics Biological Research

Yong Tian - University of Chinese Academy of Sciences

Xuan Zhang - University of Chinese Academy of Sciences

Hao Chen - Southern University of Science and Technology

View All

Personal Information