Areas of Focus
- Embryonic Stem Cells
- Pluripotency
Academic Background & Achievements
- 2003-09--2006-07 PhD: Peking University
Publications
- Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution, 9th author, 2023
- tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis, Corresponding author, 2023
- Targeting non-muscle myosin II inhibits proliferative vitreoretinopathy through regulating epithelial-mesenchymal transition, Corresponding author, 2023
- Live-cell imaging reveals redox metabolic reprogramming during zygotic genome activation, 9th author, 2023
- CDetection.v2: One-pot assay for the detection of SARS-CoV-2, 16th author, 2023
- Influence of feeder cells on transcriptomic analysis of pluripotent stem cells, 7th author, 2022
- Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver, 10th author, 2022
- Rational engineering of adeno-associated virus capsid enhances human hepatocyte tropism and reduces immunogenicity, 8th author, 2022
- Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts, Corresponding author, 2022
- Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons, 8th author, 2022
- Enhancing targeted transgene knock-in by donor recruitment, Corresponding author, 2021
- TRANSCRIPTOME AND DNA METHYLATION PROFILES OF MOUSE FETUS AND PLACENTA GENERATED BY ROUND SPERMATID INJECTION, 7th author, 2021
- CONTINUOUS EXPRESSION OF REPROGRAMMING FACTORS INDUCES AND MAINTAINS MOUSE PLURIPOTENCY WITHOUT SPECIFIC GROWTH FACTORS AND SIGNALING INHIBITORS, Corresponding author, 2021
- Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells, Corresponding author, 2020
- Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs, 11th author, 2020
- IL2RG-deficient minipigs generated via CRISPR/Cas9 technology support the growth of human melanoma-derived tumours, 9th author, 2020
- Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy, 10th author, 2020
- Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Corresponding author, 2020
- Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, Corresponding author, 2020
- The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies, 10th author, 2019
- Dynamic methylome of internal mRNA N^7-methylguanosine and its regulatory role in translation, 4th author, 2019
- Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, 8th author, 2019
- Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, Corresponding author, 2019
- Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells, 9th author, 2019
- Reprogramming of fibroblasts to uterine glandular epithelium by a chemical cocktail induction, Corresponding author, 2019
- MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, Corresponding author, 2018
- RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells, Corresponding author, 2018
- MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, 1st author, 2018
- A fully defined static suspension culture system for large-scale human embryonic stem cell production, 6th author, 2018
- Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, 10th author, 2018
- Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions, 9th author, 2018
- Mitochondrially produced ATP affects stem cell pluripotency via ActI6a-mediated histone acetylation, 1st author, 2018
- A single-cell snapshot of cell-fate decisions, 1st author, 2017
- Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, 14th author, 2017
- 单倍体胚胎干细胞的获得与应用前景, 1st author, 2017
- EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1, Corresponding author, 2016
- 人类胚胎基因编辑——科学与伦理, 2nd author, 2016
- Ubiquitously Expressed Genes Participate in Cell-Specific Functions via Alternative Promoter Usage, 8th author, 2016
- m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency, 3rd author, 2015
- MicroRNA-323-3p Regulates the Activity of Polycomb Repressive Complex 2 (PRC2) via Targeting the mRNA of Embryonic Ectoderm Development (Eed) Gene in Mouse Embryonic Stem Cells, 1st author, 2013
- Identification of a Small Molecule 1,4-bis-4-(3-Phenoxy-Propoxy)-but-2-Ynyl-Piperazine as a Novel Inhibitor of the Transcription Factor p53, 2nd author, 2013
- iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation, 4th author, 2011
