Professor | Mingzhao Zhu | Asia Growth Partners

Name	Mingzhao Zhu
Contact Information	zhumz@im.ac.cn
Language ability	Chinese, English
Province	Beijing

Name

Mingzhao Zhu

Contact Information

zhumz@im.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1998-09--2003-07 PhD: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences 1994-09--1998-07 Bachelor: School of Life Sciences, Peking University
Work Experience	2023-11~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher 2009-10~2023-11 - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2009-01~2009-12 - University of Chicago - Research Assistant Professor 2004-01~2008-12 - University of Chicago - Postdoctoral Fellow
Awards	National Science Fund for Distinguished Young Scholars (2020): National Level Chinese Academy of Sciences Award (2010): Ministerial Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1998-09--2003-07 PhD: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
1994-09--1998-07 Bachelor: School of Life Sciences, Peking University

Work Experience

2023-11~Present - Institute of Microbiology, Chinese Academy of Sciences - Researcher
2009-10~2023-11 - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2009-01~2009-12 - University of Chicago - Research Assistant Professor
2004-01~2008-12 - University of Chicago - Postdoctoral Fellow

Awards

National Science Fund for Distinguished Young Scholars (2020): National Level
Chinese Academy of Sciences Award (2010): Ministerial Level

Areas of Focus	T Cell Immunity and Vaccine Immunity Lymphoid Tissue Microenvironment
Publications	Research progress in mechanism of T cell senescence, Mingzhao Zhu, 2023 Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells, Mingzhao Zhu, 2022 Immunological perspectives on spatial and temporal vaccine delivery, Mingzhao Zhu, 2021 Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates, Mingzhao Zhu, 2021 Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice, Mingzhao Zhu, 2021 CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice, Mingzhao Zhu, 2021 Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells, Mingzhao Zhu, 2021 Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT beta R Pathway during Listeria Infection, Mingzhao Zhu, 2020 RelB regulates the homeostatic proliferation but not the function of Tregs, Mingzhao Zhu, 2020 TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway, Mingzhao Zhu, 2020 H2A.Z facilitates licensing and activation of early replication origins, Mingzhao Zhu, 2020 Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B, Mingzhao Zhu, 2020 TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via MEK/ERK signaling pathway, Mingzhao Zhu, 2019 Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy, Mingzhao Zhu, 2019 Langerhans cells control lymphatic vessel function during inflammation via direct LIGHT-LTbR signaling, Mingzhao Zhu, 2019 Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT beta R Signaling, Mingzhao Zhu, 2019 CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development, Mingzhao Zhu, 2019 T cell-derived lymphotoxin limits Th1 response during HSV-1 infection, Mingzhao Zhu, 2018 RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018 Differential Roles of LT beta R in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation, Mingzhao Zhu, 2018 T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response, Mingzhao Zhu, 2018 Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-beta receptor, Mingzhao Zhu, 2018 Differential roles of LTbR in endothelial cell subsets for lymph node organogenesis and maturation, Mingzhao Zhu, 2018 Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor, Mingzhao Zhu, 2018 RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018 Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion, Mingzhao Zhu, 2018 Immune cell trafficking and dynamic immunity, Mingzhao Zhu, 2018 Dual targeting of innate and adaptive checkpoints on tumor cells limits immune evasion, Mingzhao Zhu, 2018 Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine, Mingzhao Zhu, 2017 Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy, Mingzhao Zhu, 2017 The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation, Mingzhao Zhu, 2017 LTbR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration, Mingzhao Zhu, 2016 Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration, Mingzhao Zhu, 2016 A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice, Mingzhao Zhu, 2016 Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon, Mingzhao Zhu, 2015 Epithelial lymphotoxin beta receptor regulates embryonic medullary thymic epithelial cell development for central tolerance, Mingzhao Zhu, 2014 Recruitment of adult thymic progenitors is regulated by lymphotoxin beta receptor, Mingzhao Zhu, 2014 A novel method for synthetic vaccine construction based on protein assembly, Mingzhao Zhu, 2014 Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression, Mingzhao Zhu, 2013 Medullary thymic epithelial cells, the indispensable player in central tolerance, Mingzhao Zhu, 2013 Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012 Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012 LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy, Mingzhao Zhu, 2011 Deflating the Lymph Node, Mingzhao Zhu, 2011 The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling, Mingzhao Zhu, 2011 Direct and indirect roles of the LT beta R pathway in central tolerance induction, Mingzhao Zhu, 2010 The complicated role of NF-kappa B in T-cell selection, Mingzhao Zhu, 2010 The complicated role of NF-κB in T-cell selection, Mingzhao Zhu, 2010 Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition, Mingzhao Zhu, 2010 Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition, Mingzhao Zhu, 2009 Immunoregulation by tumor necrosis factor superfamily member LIGHT, Mingzhao Zhu, 2009 Coordinating Development of Medullary Thymic Epithelial Cells, Mingzhao Zhu, 2008 Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla, Mingzhao Zhu, 2007 NF-kappa B2 is required for the establishment of central tolerance through an Aire-dependent pathway, Mingzhao Zhu, 2006 Enhancement of Herpes Simplex Virus-1 Glycoprotein-D DNA Vaccine Induced

Areas of Focus

T Cell Immunity and Vaccine Immunity
Lymphoid Tissue Microenvironment

Publications

Research progress in mechanism of T cell senescence, Mingzhao Zhu, 2023
Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells, Mingzhao Zhu, 2022
Immunological perspectives on spatial and temporal vaccine delivery, Mingzhao Zhu, 2021
Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates, Mingzhao Zhu, 2021
Ferritin nanoparticle-based SARS-CoV-2 RBD vaccine induces a persistent antibody response and long-term memory in mice, Mingzhao Zhu, 2021
CD146 bound to LCK promotes TCR signaling and anti-tumor immune response in mice, Mingzhao Zhu, 2021
Thymic Egress Is Regulated by T Cell-Derived LTβR Signal and via Distinct Thymic Portal Endothelial Cells, Mingzhao Zhu, 2021
Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LT beta R Pathway during Listeria Infection, Mingzhao Zhu, 2020
RelB regulates the homeostatic proliferation but not the function of Tregs, Mingzhao Zhu, 2020
TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway, Mingzhao Zhu, 2020
H2A.Z facilitates licensing and activation of early replication origins, Mingzhao Zhu, 2020
Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B, Mingzhao Zhu, 2020
TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via MEK/ERK signaling pathway, Mingzhao Zhu, 2019
Ferritin nanoparticle-based SpyTag/SpyCatcher-enabled click vaccine for tumor immunotherapy, Mingzhao Zhu, 2019
Langerhans cells control lymphatic vessel function during inflammation via direct LIGHT-LTbR signaling, Mingzhao Zhu, 2019
Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT beta R Signaling, Mingzhao Zhu, 2019
CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development, Mingzhao Zhu, 2019
T cell-derived lymphotoxin limits Th1 response during HSV-1 infection, Mingzhao Zhu, 2018
RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018
Differential Roles of LT beta R in Endothelial Cell Subsets for Lymph Node Organogenesis and Maturation, Mingzhao Zhu, 2018
T Cell-Derived Lymphotoxin Is Essential for the Anti-Herpes Simplex Virus 1 Humoral Immune Response, Mingzhao Zhu, 2018
Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-beta receptor, Mingzhao Zhu, 2018
Differential roles of LTbR in endothelial cell subsets for lymph node organogenesis and maturation, Mingzhao Zhu, 2018
Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor, Mingzhao Zhu, 2018
RelB intrinsically regulates the development and function of medullary thymic epithelial cells, Mingzhao Zhu, 2018
Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion, Mingzhao Zhu, 2018
Immune cell trafficking and dynamic immunity, Mingzhao Zhu, 2018
Dual targeting of innate and adaptive checkpoints on tumor cells limits immune evasion, Mingzhao Zhu, 2018
Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine, Mingzhao Zhu, 2017
Lymphotoxin signalling in tertiary lymphoid structures and immunotherapy, Mingzhao Zhu, 2017
The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation, Mingzhao Zhu, 2017
LTbR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration, Mingzhao Zhu, 2016
Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration, Mingzhao Zhu, 2016
A novel dendritic cell targeting HPV16 E7 synthetic vaccine in combination with PD-L1 blockade elicits therapeutic antitumor immunity in mice, Mingzhao Zhu, 2016
Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon, Mingzhao Zhu, 2015
Epithelial lymphotoxin beta receptor regulates embryonic medullary thymic epithelial cell development for central tolerance, Mingzhao Zhu, 2014
Recruitment of adult thymic progenitors is regulated by lymphotoxin beta receptor, Mingzhao Zhu, 2014
A novel method for synthetic vaccine construction based on protein assembly, Mingzhao Zhu, 2014
Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression, Mingzhao Zhu, 2013
Medullary thymic epithelial cells, the indispensable player in central tolerance, Mingzhao Zhu, 2013
Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012
Proinflammatory IL-17 induces iBALT development, Mingzhao Zhu, 2012
LIGHT Regulates Inflamed Draining Lymph Node Hypertrophy, Mingzhao Zhu, 2011
Deflating the Lymph Node, Mingzhao Zhu, 2011
The role of core TNF/LIGHT family members in lymph node homeostasis and remodeling, Mingzhao Zhu, 2011
Direct and indirect roles of the LT beta R pathway in central tolerance induction, Mingzhao Zhu, 2010
The complicated role of NF-kappa B in T-cell selection, Mingzhao Zhu, 2010
The complicated role of NF-κB in T-cell selection, Mingzhao Zhu, 2010
Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition, Mingzhao Zhu, 2010
Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition, Mingzhao Zhu, 2009
Immunoregulation by tumor necrosis factor superfamily member LIGHT, Mingzhao Zhu, 2009
Coordinating Development of Medullary Thymic Epithelial Cells, Mingzhao Zhu, 2008
Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla, Mingzhao Zhu, 2007
NF-kappa B2 is required for the establishment of central tolerance through an Aire-dependent pathway, Mingzhao Zhu, 2006
Enhancement of Herpes Simplex Virus-1 Glycoprotein-D DNA Vaccine Induced

T Cells Immunity Vaccines Lymphoid Tissue Microenvironment Immunology Cell Biology Research Biomedicine Therapeutics

Lin Guo - University of Chinese Academy of Sciences

Shi-Lin Xu - University of Chinese Academy of Sciences

Peng Tan - Southern University of Science and Technology

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