Professor | Rui Yue | Asia Growth Partners

Name	Rui Yue
Contact Information	ryue@tongji.edu.cn
Language ability	English, Chinese
Province	Shanghai

Name

Rui Yue

Contact Information

ryue@tongji.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Tongji University
Faculty	Life Sciences
Academic Background & Achievements	2005 - Bachelor of Engineering, Zhejiang University 2011 - PhD in Biochemistry and Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences Awards: Wu Rui Scholarship, CAS President's Special Prize, CAS Outstanding PhD Thesis Award, CAS Graduate School-BHP Billiton Scholarship, Meiji Dairy Life Science Award
Work Experience	2011-2016 - Postdoctoral Researcher, University of Texas Southwestern Medical Center 2016-present - Professor at Tongji University, Researcher at Shanghai Key Laboratory of Signal Transduction and Disease Research
Awards	Damon Runyon Fellowship Dean's Discretionary Award at UT Southwestern Medical Center

University/Lab Affiliation and Title

Tongji University

Faculty

Life Sciences

Academic Background & Achievements

2005 - Bachelor of Engineering, Zhejiang University
2011 - PhD in Biochemistry and Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Awards: Wu Rui Scholarship, CAS President's Special Prize, CAS Outstanding PhD Thesis Award, CAS Graduate School-BHP Billiton Scholarship, Meiji Dairy Life Science Award

Work Experience

2011-2016 - Postdoctoral Researcher, University of Texas Southwestern Medical Center
2016-present - Professor at Tongji University, Researcher at Shanghai Key Laboratory of Signal Transduction and Disease Research

Awards

Damon Runyon Fellowship
Dean's Discretionary Award at UT Southwestern Medical Center

Areas of Focus	Skeletal stem cells and hematopoietic microenvironment Novel skeletal stem cell identification and regulatory mechanisms Development of new drugs for osteoporosis and osteoarthritis Composition of hematopoietic stem cell microenvironment and in vitro remodeling Rejuvenation of aging hematopoietic stem cells and clinical applications
Publications	Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation, Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., and Yue, R., 2023 Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP, Sun, Y., Ma, M., Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L., Xu, D., and Yue, R., 2023 Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton, Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., and Yue, R., 2023 Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, Fan, A., Wu, G., Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F., and Yue, R., 2023 Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?, Zhu, Q., Ding, L., and Yue, R., 2022 Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools, Mo, C., Guo, J., Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L., and Yue, R., 2022 Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses, He, J., Yan, J., Wang, J., Zhao, L., Xin, Q., Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H., Liu, B., and Yue, R., 2021 Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target, Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., and Yue, R., 2020 Advice for the Next Generation: Rui Yue, Yue, R., 2019 Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass, Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., and Morrison, S. J., 2019 Mapping the Mouse Cell Atlas by Microwell-Seq, Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., and Guo, G., 2018 Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF, Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., and Morrison, S. J., 2017 Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton, Yue, R., Shen, B., and Morrison, S. J., 2016 Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow, Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., and Morrison, S. J., 2016 Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., and Morrison, S. J., 2014 Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis, Li, H., Yue, R., Wei, B., Gao, G., Du, J., and Pei, G., 2014 Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., and Pei, G., 2012 Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., and Pei, G., 2009

Areas of Focus

Skeletal stem cells and hematopoietic microenvironment
Novel skeletal stem cell identification and regulatory mechanisms
Development of new drugs for osteoporosis and osteoarthritis
Composition of hematopoietic stem cell microenvironment and in vitro remodeling
Rejuvenation of aging hematopoietic stem cells and clinical applications

Publications

Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation, Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M., Wei, Y., Wang, L., Liao, Y., Wang, Q., Yang, L., Xu, X., Gao, Y., Gao, S., Wang, J., and Yue, R., 2023
Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP, Sun, Y., Ma, M., Cao, D., Zheng, A., Zhang, Y., Su, Y., Wang, J., Xu, Y., Zhou, M., Tang, Y., Liu, Y., Ma, T., Fan, A., Zhang, X., Zhu, Q., Qin, J., Mo, C., Xu, Y., Zhang, L., Xu, D., and Yue, R., 2023
Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton, Wang, J., Zhu, Q., Cao, D., Peng, Q., Zhang, X., Li, C., Zhang, C., Zhou, B. O., and Yue, R., 2023
Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression, Fan, A., Wu, G., Wang, J., Lu, L., Wang, J., Wei, H., Sun, Y., Xu, Y., Mo, C., Zhang, X., Pang, Z., Pan, Z., Wang, Y., Lu, L., Fu, G., Ma, M., Zhu, Q., Cao, D., Qin, J., Yin, F., and Yue, R., 2023
Skeletal stem cells: a game changer of skeletal biology and regenerative medicine?, Zhu, Q., Ding, L., and Yue, R., 2022
Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools, Mo, C., Guo, J., Qin, J., Zhang, X., Sun, Y., Wei, H., Cao, D., Zhang, Y., Zhao, C., Xiong, Y., Zhang, Y., Sun, Y., Shen, L., and Yue, R., 2022
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses, He, J., Yan, J., Wang, J., Zhao, L., Xin, Q., Zeng, Y., Sun, Y., Zhang, H., Bai, Z., Li, Z., Ni, Y., Gong, Y., Li, Y., He, H., Bian, Z., Lan, Y., Ma, C., Bian, L., Zhu, H., Liu, B., and Yue, R., 2021
Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target, Wei, H., Xu, Y., Wang, Y., Xu, L., Mo, C., Li, L., Shen, B., Sun, Y., Cheng, P., Yang, L., Pang, Y., Qin, A., Cao, Y., Morrison, S. J., and Yue, R., 2020
Advice for the Next Generation: Rui Yue, Yue, R., 2019
Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass, Shen, B., Vardy, K., Hughes, P., Tasdogan, A., Zhao, Z., Yue, R., Crane, G. M., and Morrison, S. J., 2019
Mapping the Mouse Cell Atlas by Microwell-Seq, Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., Huang, D., Xu, Y., Huang, W., Jiang, M., Jiang, X., Mao, J., Chen, Y., Lu, C., Xie, J., Fang, Q., Wang, Y., Yue, R., Li, T., Huang, H., Orkin, S. H., Yuan, G. C., Chen, M., and Guo, G., 2018
Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF, Zhou, B. O., Yu, H., Yue, R., Zhao, Z., Rios, J. J., Naveiras, O., and Morrison, S. J., 2017
Clec11a/osteolectin is an osteogenic growth factor that promotes the maintenance of the adult skeleton, Yue, R., Shen, B., and Morrison, S. J., 2016
Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow, Yue, R., Zhou, B. O., Shimada, I. S., Zhao, Z., and Morrison, S. J., 2016
Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow, Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., and Morrison, S. J., 2014
Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis, Li, H., Yue, R., Wei, B., Gao, G., Du, J., and Pei, G., 2014
Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition, Yue, R., Li, H., Liu, H., Li, Y., Wei, B., Gao, G., Jin, Y., Liu, T., Wei, L., Du, J., and Pei, G., 2012
Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression, Yue, R., Kang, J., Zhao, C., Hu, W., Tang, Y., Liu, X., and Pei, G., 2009

Skeletal Stem Cells Hematopoietic Microenvironment Identification Regulatory Osteoporosis Osteoarthritis Rejuvenation Clinical Applications

Xiaolei Yin - Tongji University

Xuechun Xia - Shanghai Jiao Tong University

Chunhua Zhao - Shanghai University

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