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Thomas A. Steitz
Life Science
Fudan University
Connecticut
Language: English
Structural Biology
Biochemistry
Molecular Mechanisms
Proteins
Nucleic Acids
Dna Replication
Transcription
Translation
Central Dogma
Biological Functions
Areas of Focus
- Using structural biology and biochemistry to determine the detailed molecular mechanisms by which the proteins and nucleic acids involved in the central dogma of molecular biology (DNA replication, transcription, and translation) achieve their biological functions.
Work Experience
- 1970-present Yale University - Sterling Professor of Molecular Biophysics and Biochemistry
- 1970-present Howard Hughes Medical Institute - Researcher
Academic Background & Achievements
- 1962 B.A. in Chemistry: Lawrence College
- 1966 Ph.D. in Molecular Biology and Biochemistry: Harvard University
- 1967-1970 Postdoctoral Research: MRC Laboratory of Molecular Biology, University of Cambridge
- 2009 Nobel Prize in Chemistry: For studies of the structure and function of the ribosome
Publications
- Elongation factor 4 remodels the A-site tRNA on the ribosome, Gagnon, M. G., Lin, J. & Steitz, T. A., 2016
- Conformational changes of elongation factor G on the ribosome during tRNA translocation, Lin, J., Gagnon, M.G., Bulkley, D., Steitz, T.A., 2015
- Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome, Gagnon, M.G., Lin, J., Bulkley, D., Steitz, T.A., 2014
- The initiation of mammalian protein synthesis and mRNA scanning mechanism, Lomakin, I., Steitz, T.A., 2013
- The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex, Zuo, Y., Wang, Y., Steitz, T.A., 2013
- How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis, Polikanov, Y.I., Blaha, G.M. Steitz, T.A., 2012
- The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation, Itsathitphaisarn, O., Wing, R.A., Eliason, W.K., Wang, J., Steitz, T.A., 2012
- Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome, Gagnon, M.G., Seetharaman, S.V., Bulkley, D., Steitz, T.A., 2012
Awards
- Foreign Member, the Royal Society (2011)
- Nobel Prize in Chemistry (2009)
- Gairdner International Award (2007)
- Keio Medical Science Prize (2006)
- AAAS Newcomb Cleveland Prize (2001)
- Rosenstiel Award for Distinguished Work in Basic Medical Research (2001)
- Member, National Academy of Sciences (1990)
- Pfizer Award in Enzyme Chemistry (1980)
