Professor | Chen Xizi | Asia Growth Partners

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Name	Chen Xizi
Contact Information	chenxz@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Chen Xizi

Contact Information

chenxz@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	2019 PhD in Biochemistry and Molecular Biology: Fudan University 2021 China's Top Ten Advances in Life Sciences 2021 China's Important Medical Advances
Work Experience	2019-2021 - Fudan University Affiliated Cancer Hospital - Assistant Researcher 2022-Present - School of Life Sciences, Fudan University - Junior Researcher
Awards	2022: Selected for the 7th Young Talent Support Program by the China Association for Science and Technology

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

2019 PhD in Biochemistry and Molecular Biology: Fudan University
2021 China's Top Ten Advances in Life Sciences
2021 China's Important Medical Advances

Work Experience

2019-2021 - Fudan University Affiliated Cancer Hospital - Assistant Researcher
2022-Present - School of Life Sciences, Fudan University - Junior Researcher

Awards

2022: Selected for the 7th Young Talent Support Program by the China Association for Science and Technology

Areas of Focus	Biochemistry and Structural Biology (Cryo-EM) methods to study the structure and function of key protein complexes in eukaryotic gene transcription, exploring transcription regulation mechanisms
Publications	Structures of the human Mediator and Mediator-bound preinitiation complex, Chen, X., Yin, X., Li, J., Wu, Z., Qi, Y., Wang, X., Liu, W., and Xu, Y., 2021 Structural insights into preinitiation complex assembly on core promoters, Chen, X., Qi, Y., Wu, Z., Wang, X., Li, J., Zhao, D., Hou, H., Li, Y., Yu, Z., Liu, W., Wang, M., Ren, Y., Li, Z., Yang, H., and Xu, Y., 2021 RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang, X., Qi, Y., Wang, Z., Wang, L., Song, A., Tao, B., Li, J., Zhao, D., Zhang, H., Jin, Q., Jiang, Y., Chen, F. X., Xu, Y., and Chen, X., 2022 Cryo-EM structure of human mTOR complex 2, Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H., and Xu, Y., 2018 Structural insights into TSC complex assembly and GAP activity on Rheb, Yang, H., Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H. X., Ye, D., Guan, K. L., and Xu, Y., 2021 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1, Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y., and Wang, H. W., 2016 Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng, H., Qi, Y., Hu, S., Cao, X., Xu, C., Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K., Chen, F. X., and Xu, Y., 2020

Areas of Focus

Biochemistry and Structural Biology (Cryo-EM) methods to study the structure and function of key protein complexes in eukaryotic gene transcription, exploring transcription regulation mechanisms

Publications

Structures of the human Mediator and Mediator-bound preinitiation complex, Chen, X., Yin, X., Li, J., Wu, Z., Qi, Y., Wang, X., Liu, W., and Xu, Y., 2021
Structural insights into preinitiation complex assembly on core promoters, Chen, X., Qi, Y., Wu, Z., Wang, X., Li, J., Zhao, D., Hou, H., Li, Y., Yu, Z., Liu, W., Wang, M., Ren, Y., Li, Z., Yang, H., and Xu, Y., 2021
RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang, X., Qi, Y., Wang, Z., Wang, L., Song, A., Tao, B., Li, J., Zhao, D., Zhang, H., Jin, Q., Jiang, Y., Chen, F. X., Xu, Y., and Chen, X., 2022
Cryo-EM structure of human mTOR complex 2, Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H., and Xu, Y., 2018
Structural insights into TSC complex assembly and GAP activity on Rheb, Yang, H., Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H. X., Ye, D., Guan, K. L., and Xu, Y., 2021
4.4 A Resolution Cryo-EM structure of human mTOR Complex 1, Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y., and Wang, H. W., 2016
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng, H., Qi, Y., Hu, S., Cao, X., Xu, C., Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K., Chen, F. X., and Xu, Y., 2020

Biochemistry Structural Biology Cryo-Em Gene Transcription Protein Complexes Eukaryotic Cells Transcription Regulation Molecular Biology Protein Structure Functional Analysis

Yanfang Wang - Tongji University

Shaojun Dai - Shanghai Normal University

Shui Wang - Shanghai Normal University

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