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Chen Xizi
Life Science
Fudan University
Shanghai
Language: Chinese, English
Biochemistry
Structural Biology
Cryo-Em
Gene Transcription
Protein Complexes
Eukaryotic Cells
Transcription Regulation
Molecular Biology
Protein Structure
Functional Analysis
Areas of Focus
- Biochemistry and Structural Biology (Cryo-EM) methods to study the structure and function of key protein complexes in eukaryotic gene transcription, exploring transcription regulation mechanisms
Work Experience
- 2019-2021 - Fudan University Affiliated Cancer Hospital - Assistant Researcher
- 2022-Present - School of Life Sciences, Fudan University - Junior Researcher
Academic Background & Achievements
- 2019 PhD in Biochemistry and Molecular Biology: Fudan University
- 2021 China's Top Ten Advances in Life Sciences
- 2021 China's Important Medical Advances
Publications
- Structures of the human Mediator and Mediator-bound preinitiation complex, Chen, X., Yin, X., Li, J., Wu, Z., Qi, Y., Wang, X., Liu, W., and Xu, Y., 2021
- Structural insights into preinitiation complex assembly on core promoters, Chen, X., Qi, Y., Wu, Z., Wang, X., Li, J., Zhao, D., Hou, H., Li, Y., Yu, Z., Liu, W., Wang, M., Ren, Y., Li, Z., Yang, H., and Xu, Y., 2021
- RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex, Wang, X., Qi, Y., Wang, Z., Wang, L., Song, A., Tao, B., Li, J., Zhao, D., Zhang, H., Jin, Q., Jiang, Y., Chen, F. X., Xu, Y., and Chen, X., 2022
- Cryo-EM structure of human mTOR complex 2, Chen, X., Liu, M., Tian, Y., Li, J., Qi, Y., Zhao, D., Wu, Z., Huang, M., Wong, C. C. L., Wang, H. W., Wang, J., Yang, H., and Xu, Y., 2018
- Structural insights into TSC complex assembly and GAP activity on Rheb, Yang, H., Yu, Z., Chen, X., Li, J., Li, N., Cheng, J., Gao, N., Yuan, H. X., Ye, D., Guan, K. L., and Xu, Y., 2021
- 4.4 A Resolution Cryo-EM structure of human mTOR Complex 1, Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M. Q., Wong, C. C., Wang, J., Xu, Y., and Wang, H. W., 2016
- Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase, Zheng, H., Qi, Y., Hu, S., Cao, X., Xu, C., Yin, Z., Chen, X., Li, Y., Liu, W., Li, J., Wang, J., Wei, G., Liang, K., Chen, F. X., and Xu, Y., 2020
Awards
- 2022: Selected for the 7th Young Talent Support Program by the China Association for Science and Technology
