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Yu Ding
Life Science
Fudan University
Shanghai
Language: Chinese, English
Autophagy
Lysosome
Pathogenic
Macromolecular
Targeted
Degradation
Technology
Attec
Nanobody
Biotechnology
Areas of Focus
- Autophagy-Lysosome-Based Pathogenic Macromolecular Targeted Degradation Technology (ATTEC)
- Nanobody Technology
Work Experience
- 2004 - Fudan University - Lecturer
- 2007 - Fudan University - Associate Professor
- 2020 - Fudan University - Professor
- 2009-2011 - University of Hong Kong - Exchange Program at the Department of Chemistry
Academic Background & Achievements
- 1996-1999 Bachelor's Degree: School of Life Sciences, Fudan University
- 1999-2004 Ph.D. in Biophysics: School of Life Sciences, Fudan University
- Selected for the Shanghai Eastern Scholar Program
Publications
- Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds, Z Li, C Wang, Z Wang, C Zhu, J Li, T Sha, L Ma, C Gao…, Y Ding#, Y Fei#, B Lu#, 2019
- Emerging degrader technologies engaging lysosomal pathways, Y Ding#, D Xing#, Y Fei#, B Lu#, 2022
- Degradation of lipid droplets by chimeric autophagy-tethering compounds, Y Fu, N Chen, Z Wang, S Luo, Y Ding#, B Lu#, 2021
- Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies, H Liang, Z Ma, Z Wang, P Zhong, R Li, H Jiang, X Zong…, R Liu#, Y Ding#, 2023
- A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors, Y Wu#, Q Li, Y Kong, Z Wang, C Lei, J Li, L Ding…, Y Ding#, T Ying#, 2022
- Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide, H Song, C Wang, C Zhu, Z Wang, H Yang, P Wu, X Cui…, Y Ding#, Y Fei#, B Lu#, 2022
- Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry, Z Wang, L Li, R Hu, P Zhong, Y Zhang, S Cheng…, Y Ding#, 2021
- Emerging new concepts of degrader technologies, Y Ding#, Y Fei#, B Lu#, 2020
- Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling, C Jiang, Y Tang, L Ding, R Tan, X Li, J Lu, J Jiang…, Y Ding#, J Liu#, Y Dang#, 2019
- Flotillin-1 downregulates K+ current by directly coupling with Kv2. 1 subunit, R Liu, G Yang, MH Zhou, Y He, YA Mei#, Y Ding#, 2016
Awards
- Sanofi-Cell Research Outstanding Paper Award (2021)
- \"Zhong Yang-style\" Excellent Teacher (Top 10 Teachers)
- Good Teacher in the Hearts of Undergraduate and Graduate Students
- Mentored undergraduates Chen Wentao, Lu Zhisheng, and Wu Xudong, winners of the National Challenge Cup Special Prize at the 11th Challenge Cup, and received the Excellent Mentor Award
