09/1997-07/2002 Ph.D in Organic Chemistry: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
09/1993-07/1997 B.S. in Department of Pharmaceutical Chemistry: Beijing Medical University
Exceptional Pay Increase, National Cancer Institute, NIH, USA (2006)
The Excellent Graduate Award, Beijing Medical University, Beijing, China (1997)
Peking Honor Graduate Award, Beijing, China (1997)
09/2012-present - Fudan University - Professor
06/2009-08/2012 - Georgia State University - Research Scientist
04/2008-04/2009 - Memorial Sloan-Kettering Cancer Center - Research Associate
05/2003-04/2008 - National Institutes of Health - Postdoctoral Fellow
08/2002-05/2003 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Research Associate
STTR Research Award (2011): USA
The Fellows Award for Research Excellence (FARE) (2007): NIH, Bethesda, USA
The Spring Research Festival Poster Award (2007): NCI-Fort Detrick, Frederick, USA
The SER-CAT Young Investigator Award (2006): Southeast Regional Collaborative Access Team, USA
Research
Structural and functional studies of important macromolecules Pathogenesis-related proteins Proteins involved in DNA replication and DNA repair pathways Nucleic acids with catalytic activities
Structures and implications of the C962R protein of African swine fever virus, Z. Shao, S. Su, J. Yang, W. Zhang, Y. Gao, X. Zhao, Y. Zhang, Q. Shao, C. Cao, H. Li, H. Liu, J. Zhang, J. Ma, J. Gan, 2023
Crystal structures and identification of novel Cd2+-specific DNA aptamer, H. Liu, Y. Gao, J. Mathivanan, Z. Armour-Garb, Z. Shao, Y. Zhang, X. Zhao, Q. Shao, W. Zhang, J. Yang, C. Cao, H. Li, J. Sheng, J. Gan, 2023
Structural and functional studies of PCNA from African swine fever virus, Z. Shao, J. Yang, Y. Gao, Y. Zhang, X. Zhao, Q. Shao, W. Zhang, C. Cao, H. Liu, J. Gan, 2023
Crystal structures and insights into precursor tRNA 5'-end processing by prokaryotic minimal protein-only RNase P, Y. Li, S. Su, Y. Gao, G. Lu, H. Liu, X. Chen, Z. Shao, Y. Zhang, Q. Shao, X. Zhao, J. Yang, C. Cao, J. Lin, J. Ma, J. Gan, 2022
Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein, Y. Zhang, Z. Shao, Y. Gao, B. Fan, J. Yang, X. Chen, X. Zhao, Q. Shao, W. Zhang, C. Cao, H. Liu, J. Gan, 2022
Structural insights into partner selection for MYB and bHLH transcription factor complexes, B. Wang, Q. Luo, Y. Li, K. Du, Z. Wu, T. Li, W. Shen, C. Huang, J. Gan, A. Dong, 2022
Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1, R. Cui, H. Li, J. Zhao, X. Li, J. Gan, J. Ma, 2022
Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target, Y. Xu, J. Yang, W. Li, S. Song, Y. S, L. Wu, J. Sun, Me. Hou, J. Wang, X. Jia, H. Zhang, M. Huang, T. Lu, J. Gan, Y. Feng, 2022
PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa, G. Cui, Y. Zhang, X. Xu, Y. Liu, Z. Li, M. Wu, J. Liu, J. Gan, H. Liang, 2022
Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei, Y. Gao, H. Liu, C. Zhang, S. Su, Y. Chen, X. Chen, Y. Li, Z. Shao, Y. Zhang, Q. Shao, J. Li, Z. Huang, J. Ma, J. Gan, 2021
The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences, H. Jiang, Y. Gao, L. Zhang, D. Chen, J. Gan, A. Murchie, 2021
Structural studies reveal a ring-shaped architecture of deep-sea vent, X. Chen, S. Su, Y. Chen, Y. Gao, Y. Li, Z. Shao, Y. Zhang, Q. Shao, H. Liu, J. Li, J. Ma, J. Gan, 2020
A unique DNA-binding mode of African Swine fever virus AP endonuclease, Y. Chen, X. Chen, Q. Huang, Z. Shao, Y. Gao, Y. Li, C. Yang, H. Liu, J. Li, Q. Wang, J. Ma, Y. Zhang, Y. Gu, J. Gan, 2020
Catalytic-state structure and engineering of Streptococcus thermophiles Cas9, Zhang, H. Zhang, X. Xu, Y. Wang, W. Chen, Y. Wang, Z. Wu, N. Tang, Y. Wang, S. Zhao, J. Gan, Q. Ji, 2020
Structural insights into target DNA recognition by R2R3-MYB transcription factors, B. Wang, Q. Luo, Y. Li, L. Yin, N. Zhou, X Li, J. Gan, A. Dong, 2020
Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Y. Chen, H. Liu, C. Yang, Y. Gao, X. Yu, X. Chen, R. Cui, L. Zheng, S. Li, X. Li, J. Ma, Z. Huang, J. Li, J. Gan, 2019
Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Qian, H. Yu, P. Li, E. Zhu, Q. Yao, C. Tai, Z. Deng, K. Gerdes, X. He, J. Gan, H. Ou, 2019
Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease, W. Chen, H. Zhang, Y. Zhang, Y. Wang, J. Gan, Q. Ji, 2019
High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, H. Liu, R. Wang, X. Yu, F. Shen, W. Lan, P. Haruehanroengra, Q. Yao, J. Zhang, Y. Chen, S. Li, B. Wu, L. Zheng, J. Ma, J. Lin, C. Cao, J. Li, J. Sheng, J. Gan, 2018
Structural insights into DNA degradation by human mitochondrial nuclease MGME1, C. Yang, R. Wu, H. Liu, Y. Chen, Y. Gao, X. Chen, Y. Li, J. Ma, J. Li, J. Gan, 2018
Crystal structure of an RNA-cleaving DNAzyme, H. Liu, X. Yu, Y. Chen, J. Zhang, B. Wu, L. Zheng, P. Haruehanroengra, R. Wang, S. Li, J. Lin, J. Li, J. Sheng, Z. Huang, J. Ma, J. Gan, 2017
A DNA structure containing AgI-mediated G:G and C:C base pairs, H. Liu, F. Shen, P. Haruehanroengra, Q. Yao, Y. Cheng, Y. Chen, C. Yang, J. Zhang, B. Wu, Q. Luo, R. Cui, J. Li, J. Ma, J. Sheng, J. Gan, 2017
Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex, H. Liu, C. Chen, P. Haruehanroengra, Q. Yao, Y. Chen, C. Yang, Q. Luo, B. Wu, J. Li, J. Ma, J. Sheng, J. Gan, 2017
Structural insights into RNA duplexes with multiple 2’-5’-linkages, F. Shen, Z. Luo, H. Liu, R. Wang, S. Zhang, J. Gan, J. Sheng, 2017
Unique 5’-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X, Y. Chen, J. Zhang, H. Liu, Y. Gao, X. Li, L. Zheng, R. Cui, Q. Yao, L. Rong, J. Li, Z. Huang, J. Ma, J. Gan, 2017
Structural basis for single-stranded RNA recognition and cleavage by C3PO
