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Jianhua Gan
Life Science
Fudan University
Shanghai
Language: English, Chinese
X-Ray Crystallography
Biophysics
Biochemistry
Macromolecules
Pathogenesis
Dna Replication
Dna Repair
Catalytic Nucleic Acids
Protein Structure
Functional Studies
Areas of Focus
- Structural and functional studies of important macromolecules
- Pathogenesis-related proteins
- Proteins involved in DNA replication and DNA repair pathways
- Nucleic acids with catalytic activities
Work Experience
- 09/2012-present - Fudan University - Professor
- 06/2009-08/2012 - Georgia State University - Research Scientist
- 04/2008-04/2009 - Memorial Sloan-Kettering Cancer Center - Research Associate
- 05/2003-04/2008 - National Institutes of Health - Postdoctoral Fellow
- 08/2002-05/2003 - Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences - Research Associate
Academic Background & Achievements
- 09/1997-07/2002 Ph.D in Organic Chemistry: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- 09/1993-07/1997 B.S. in Department of Pharmaceutical Chemistry: Beijing Medical University
- Exceptional Pay Increase, National Cancer Institute, NIH, USA (2006)
- The Excellent Graduate Award, Beijing Medical University, Beijing, China (1997)
- Peking Honor Graduate Award, Beijing, China (1997)
Publications
- Structures and implications of the C962R protein of African swine fever virus, Z. Shao, S. Su, J. Yang, W. Zhang, Y. Gao, X. Zhao, Y. Zhang, Q. Shao, C. Cao, H. Li, H. Liu, J. Zhang, J. Ma, J. Gan, 2023
- Crystal structures and identification of novel Cd2+-specific DNA aptamer, H. Liu, Y. Gao, J. Mathivanan, Z. Armour-Garb, Z. Shao, Y. Zhang, X. Zhao, Q. Shao, W. Zhang, J. Yang, C. Cao, H. Li, J. Sheng, J. Gan, 2023
- Structural and functional studies of PCNA from African swine fever virus, Z. Shao, J. Yang, Y. Gao, Y. Zhang, X. Zhao, Q. Shao, W. Zhang, C. Cao, H. Liu, J. Gan, 2023
- Crystal structures and insights into precursor tRNA 5'-end processing by prokaryotic minimal protein-only RNase P, Y. Li, S. Su, Y. Gao, G. Lu, H. Liu, X. Chen, Z. Shao, Y. Zhang, Q. Shao, X. Zhao, J. Yang, C. Cao, J. Lin, J. Ma, J. Gan, 2022
- Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein, Y. Zhang, Z. Shao, Y. Gao, B. Fan, J. Yang, X. Chen, X. Zhao, Q. Shao, W. Zhang, C. Cao, H. Liu, J. Gan, 2022
- Structural insights into partner selection for MYB and bHLH transcription factor complexes, B. Wang, Q. Luo, Y. Li, K. Du, Z. Wu, T. Li, W. Shen, C. Huang, J. Gan, A. Dong, 2022
- Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1, R. Cui, H. Li, J. Zhao, X. Li, J. Gan, J. Ma, 2022
- Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target, Y. Xu, J. Yang, W. Li, S. Song, Y. S, L. Wu, J. Sun, Me. Hou, J. Wang, X. Jia, H. Zhang, M. Huang, T. Lu, J. Gan, Y. Feng, 2022
- PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa, G. Cui, Y. Zhang, X. Xu, Y. Liu, Z. Li, M. Wu, J. Liu, J. Gan, H. Liang, 2022
- Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei, Y. Gao, H. Liu, C. Zhang, S. Su, Y. Chen, X. Chen, Y. Li, Z. Shao, Y. Zhang, Q. Shao, J. Li, Z. Huang, J. Ma, J. Gan, 2021
- The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences, H. Jiang, Y. Gao, L. Zhang, D. Chen, J. Gan, A. Murchie, 2021
- Structural studies reveal a ring-shaped architecture of deep-sea vent, X. Chen, S. Su, Y. Chen, Y. Gao, Y. Li, Z. Shao, Y. Zhang, Q. Shao, H. Liu, J. Li, J. Ma, J. Gan, 2020
- A unique DNA-binding mode of African Swine fever virus AP endonuclease, Y. Chen, X. Chen, Q. Huang, Z. Shao, Y. Gao, Y. Li, C. Yang, H. Liu, J. Li, Q. Wang, J. Ma, Y. Zhang, Y. Gu, J. Gan, 2020
- Catalytic-state structure and engineering of Streptococcus thermophiles Cas9, Zhang, H. Zhang, X. Xu, Y. Wang, W. Chen, Y. Wang, Z. Wu, N. Tang, Y. Wang, S. Zhao, J. Gan, Q. Ji, 2020
- Structural insights into target DNA recognition by R2R3-MYB transcription factors, B. Wang, Q. Luo, Y. Li, L. Yin, N. Zhou, X Li, J. Gan, A. Dong, 2020
- Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues, Y. Chen, H. Liu, C. Yang, Y. Gao, X. Yu, X. Chen, R. Cui, L. Zheng, S. Li, X. Li, J. Ma, Z. Huang, J. Li, J. Gan, 2019
- Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex, Qian, H. Yu, P. Li, E. Zhu, Q. Yao, C. Tai, Z. Deng, K. Gerdes, X. He, J. Gan, H. Ou, 2019
- Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease, W. Chen, H. Zhang, Y. Zhang, Y. Wang, J. Gan, Q. Ji, 2019
- High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads, H. Liu, R. Wang, X. Yu, F. Shen, W. Lan, P. Haruehanroengra, Q. Yao, J. Zhang, Y. Chen, S. Li, B. Wu, L. Zheng, J. Ma, J. Lin, C. Cao, J. Li, J. Sheng, J. Gan, 2018
- Structural insights into DNA degradation by human mitochondrial nuclease MGME1, C. Yang, R. Wu, H. Liu, Y. Chen, Y. Gao, X. Chen, Y. Li, J. Ma, J. Li, J. Gan, 2018
- Crystal structure of an RNA-cleaving DNAzyme, H. Liu, X. Yu, Y. Chen, J. Zhang, B. Wu, L. Zheng, P. Haruehanroengra, R. Wang, S. Li, J. Lin, J. Li, J. Sheng, Z. Huang, J. Ma, J. Gan, 2017
- A DNA structure containing AgI-mediated G:G and C:C base pairs, H. Liu, F. Shen, P. Haruehanroengra, Q. Yao, Y. Cheng, Y. Chen, C. Yang, J. Zhang, B. Wu, Q. Luo, R. Cui, J. Li, J. Ma, J. Sheng, J. Gan, 2017
- Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex, H. Liu, C. Chen, P. Haruehanroengra, Q. Yao, Y. Chen, C. Yang, Q. Luo, B. Wu, J. Li, J. Ma, J. Sheng, J. Gan, 2017
- Structural insights into RNA duplexes with multiple 2’-5’-linkages, F. Shen, Z. Luo, H. Liu, R. Wang, S. Zhang, J. Gan, J. Sheng, 2017
- Unique 5’-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X, Y. Chen, J. Zhang, H. Liu, Y. Gao, X. Li, L. Zheng, R. Cui, Q. Yao, L. Rong, J. Li, Z. Huang, J. Ma, J. Gan, 2017
- Structural basis for single-stranded RNA recognition and cleavage by C3PO
Awards
- STTR Research Award (2011): USA
- The Fellows Award for Research Excellence (FARE) (2007): NIH, Bethesda, USA
- The Spring Research Festival Poster Award (2007): NCI-Fort Detrick, Frederick, USA
- The SER-CAT Young Investigator Award (2006): Southeast Regional Collaborative Access Team, USA
