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Xiaohua Hu
Life Science
Fudan University
Shanghai
Language: English, Chinese
Lung Cancer
Brain Tumors
Molecular Genetics
Cell Biology
Mouse Models
Bioinformatics
Driver Genes
Tumorigenesis
Phase Separation
Small Molecule Drugs
Areas of Focus
- Molecular mechanisms of lung cancer and brain tumors
- Driver genes identification and molecular mechanisms of tumorigenesis
- Mechanism of abnormal phase separation of mutant proteins and anti-tumor small molecule drugs
Work Experience
- 2006-2010 - Fudan University - Research Assistant at the Institutes of Biomedical Sciences
- 2011-present - Fudan University - Associate Professor at the School of Life Sciences
- 2018-2020 - Cincinnati Children’s Hospital Medical Center - Visiting Scientist
Academic Background & Achievements
- 2006 Ph.D. in Genetics: Fudan University
- Communication review expert for the Youth Fund and General Projects of the National Foundation of China
- Expert of the Ministry of Education for spot check review of postgraduate thesis
- Expert for inter-school review of postgraduate thesis
Publications
- Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumorigenesis, X Hu, X Wu, et al., 2023
- Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma, Pu W, …, Hu X, et al., 2021
- Identification of the copy number variant biomarkers for breast cancer subtypes, X Pan*, XH Hu*, et al., 2019
- Downregulation of DNMT3A by miR-708-5p inhibits lung cancer stem cell-like phenotypes through repressing Wnt/β-catenin signaling, T Liu, X Wu, T Chen, Z Luo, X Hu, 2018
- Gene expression differences among different MSI statuses in colorectal cancer, Chen L*, Pan X*, Hu X*, Zhang YH, Wang S, Huang T, Cai YD, 2018
- Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae, O Fang*, X Hu*, et al., 2018
- miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1, X Wu, T Liu, O Fang, LJ Leach，X Hu#, Z Luo#, 2014
- 3’ Untranslated Regions Mediate Transcriptional Interference Between Convergent Genes Both Locally and Ectopically in Saccharomyces cerevisiae, L Wang, N Jiang, L Wang, O Fang, Lindsey J. Leach, X Hu#, Z Luo#, 2014
Awards
- Fosun medical scholarship (2016)
- Outstanding teacher of the School of Life Sciences (2013, 2014)
