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Ling Chen
Life Science
Fudan University
Shanghai
Language: English, Chinese
Adeno-Associated Virus
Vectors
Capsid Protein
Optimization
Quality Control
Immune Response
Gene Expression
Iron Response Elements
Transcription
Translation
Areas of Focus
- Basic Biology of Adeno-Associated Virus and its Vectors
- Precise Induction of Gene Expression by rAAV Vectors
- Cancer Gene Therapy
Work Experience
- Post-2011 - University of Florida - Postdoctoral Researcher, Assistant Professor, Associate Professor
- 2016-Present - Fudan University - Researcher
Academic Background & Achievements
- 2007 - Bachelor's Degree: Fudan University, School of Life Sciences
- 2011 - Ph.D.: University of Florida, Medical Genetics
- 2016 - Shanghai Sailing Program Award
- 2016 - Distinguished Professor of the Oriental Scholar Program
- 2020 - Renewal of the Oriental Scholar Tracking Program
- Published over 40 SCI papers as first or corresponding author
Publications
- Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway, Wentao Jia, Shufang Liang, Wanfu Lin, Shu Li, Jiaying Yuan, Mingming Jin, Shuchang Nie, Ya'ni Zhang, Xiaofeng Zhai, Liping Zhou, Changquan Ling, Binbin Cheng, Chen Ling, 2023
- Improved Gene Therapy for MFRP Deficiency-Mediated Retinal Degeneration by Knocking Down Endogenous Bicistronic Mfrp and Ctrp5 Transcript, Xiao Tian, Qingyun Zheng, Jinyan Xie, Qinlinglan Zhou, Letong Liang, Guotong Xu, Hongyan Chen, Chen Ling, Daru Lu, 2023
- Sphingosine-1-phosphate transporter spinster homologue 2 is essential for iron-regulated metastasis of hepatocellular carcinoma, Min Li, Yuxiao Tang, Dongyao Wang, Xiaofeng Zhai, Hui Shen, Chen Zhong, Man Yao, Aiguo Jin, Zhengjun Zhou, Shaolai Zhou, Jia Fan, Chang-quan Ling, Chen Ling, 2022
- Low endotoxin E. coli strain-derived plasmids reduced rAAV vector-mediated immune responses both in vitro and in vivo, Qingyun Zheng, Tianyi Wang, Xiangying Zhu, Xiao Tian, Chen Zhong, Guolin Chang, Gai Ran, Yilin Xie, Bing Zhao, Liqing Zhu, Chen Ling, 2021
- Hepatocyte-specific HNF4α/miR-122 pathway contributes to the iron-overload mediated hepatic inflammation, Min Li, Yuxiao Tang, Lusha Wu, Fengfeng Mo, Xin Wang, Hongxia Li, Ruirui Qi, Hongwei Zhang, Arun Srivastava, Chen Ling, 2017
Awards
- 2016 - Shanghai Sailing Program Award
- 2016 - Distinguished Professor of the Oriental Scholar Program
- 2020 - Renewal of the Oriental Scholar Tracking Program
