Professor | Xinhua Lin | Asia Growth Partners

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Name	Xinhua Lin
Contact Information	xlin@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xinhua Lin

Contact Information

xlin@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	1980-1984 Bachelor's Degree: Hangzhou University (now Zhejiang University) 1984-1987 Master's Degree: Shanghai Institute of Cell Biology, Chinese Academy of Sciences 1990-1995 Ph.D.: Washington University at St. Louis 1995-2000 Postdoctoral Research: Harvard Medical School Published over 80 research papers in journals like Cell, Nature, Nat Cell Biol, Dev Cell, Cell Res, Nat Commun, J Clin Invest
Work Experience	2000-2009 - Cincinnati Children's Hospital Medical Center - Assistant Professor, Tenured Associate Professor, Tenured Professor 2009-2016 - Institute of Zoology, Chinese Academy of Sciences - Researcher, Director of the State Key Laboratory of Membrane Biology 2016-present - Fudan University - Professor, Dean of School of Life Sciences, Director of the State Key Laboratory of Genetic Engineering, Director of the Institute of Genetics, Executive Dean of the Guangdong-Hong Kong-Macao Greater Bay Area Institute of Precision Medicine
Awards	2010: Chief Scientist, National Key Research and Development Program (973) 2007-2011: American Cancer Society Scholar Award 2007: National Natural Science Foundation of China Outstanding Young Scientist Award (Category B) 2005: Honorary Professor, Zhejiang University 2005-2008: March of Dimes Foundation Research Award 2002-2004: Basil O’Connor Starter Scholar Research Award 2001-2003: Ohio Cancer Research Award 1997-2000: U.S. Army Breast Cancer Research Postdoctoral Fellowship 1999: Young Scientist Award, 15th International Symposium on Glycoconjugates, Japan 1995-1997: Howard Hughes Medical Institute Postdoctoral Fellowship 1998: Outstanding Research Award, Shanghai Institute of Cell Biology

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

1980-1984 Bachelor's Degree: Hangzhou University (now Zhejiang University)
1984-1987 Master's Degree: Shanghai Institute of Cell Biology, Chinese Academy of Sciences
1990-1995 Ph.D.: Washington University at St. Louis
1995-2000 Postdoctoral Research: Harvard Medical School
Published over 80 research papers in journals like Cell, Nature, Nat Cell Biol, Dev Cell, Cell Res, Nat Commun, J Clin Invest

Work Experience

2000-2009 - Cincinnati Children's Hospital Medical Center - Assistant Professor, Tenured Associate Professor, Tenured Professor
2009-2016 - Institute of Zoology, Chinese Academy of Sciences - Researcher, Director of the State Key Laboratory of Membrane Biology
2016-present - Fudan University - Professor, Dean of School of Life Sciences, Director of the State Key Laboratory of Genetic Engineering, Director of the Institute of Genetics, Executive Dean of the Guangdong-Hong Kong-Macao Greater Bay Area Institute of Precision Medicine

Awards

2010: Chief Scientist, National Key Research and Development Program (973)
2007-2011: American Cancer Society Scholar Award
2007: National Natural Science Foundation of China Outstanding Young Scientist Award (Category B)
2005: Honorary Professor, Zhejiang University
2005-2008: March of Dimes Foundation Research Award
2002-2004: Basil O’Connor Starter Scholar Research Award
2001-2003: Ohio Cancer Research Award
1997-2000: U.S. Army Breast Cancer Research Postdoctoral Fellowship
1999: Young Scientist Award, 15th International Symposium on Glycoconjugates, Japan
1995-1997: Howard Hughes Medical Institute Postdoctoral Fellowship
1998: Outstanding Research Award, Shanghai Institute of Cell Biology

Areas of Focus	Developmental Genetics and Stem Cell Biology
Publications	Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression, Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B, Jiang N, Li R, Lin X, 2022 Modeling human thyroid development by fetal tissue-derived organoid culture, Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X, Zhao B, 2022 Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids, Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R, Lin X, 2020 Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation, Zhao B, Chen Y, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G, Lin X, 2019 EMC3 coordinates surfactant protein and lipid homeostasis required for respiration, Tang X, Snowball M, Xu Y, Na C, Weaver T, Clair G, Kyle J, Zink E, Ansong C, Wei W, Huang M, Lin X, Whitsett J, 2017 Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development, He H, Huang M, Sun S, Wu Y, Lin X, 2017 Trachea-derived Dpp controls adult midgut homeostasis in Drosophila, Li Z, Zhang Y, Han L, Shi L, Lin X, 2013 SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless, Zhang P, Wu Y, Belenkaya T, Lin X, 2011 The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling, Yan D, Wu Y, Feng Y, Lin S, Lin X, 2009 The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network, Belenkaya T, Wu Y, Tang X, Zhou B, Cheng L, Sharma Y, Yan D, Selva E, Lin X, 2008 DrosophilaDpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans, Belenkaya T, Han C, Yan D, Opoka R, Khodoun M, Liu H, Lin X, 2004 Dally cooperates with DrosophilaFrizzled 2 to transduce Wingless signalling, Lin X, Perrimon N, 1999

Areas of Focus

Developmental Genetics and Stem Cell Biology

Publications

Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression, Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B, Jiang N, Li R, Lin X, 2022
Modeling human thyroid development by fetal tissue-derived organoid culture, Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X, Zhao B, 2022
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids, Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R, Lin X, 2020
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation, Zhao B, Chen Y, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G, Lin X, 2019
EMC3 coordinates surfactant protein and lipid homeostasis required for respiration, Tang X, Snowball M, Xu Y, Na C, Weaver T, Clair G, Kyle J, Zink E, Ansong C, Wei W, Huang M, Lin X, Whitsett J, 2017
Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development, He H, Huang M, Sun S, Wu Y, Lin X, 2017
Trachea-derived Dpp controls adult midgut homeostasis in Drosophila, Li Z, Zhang Y, Han L, Shi L, Lin X, 2013
SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless, Zhang P, Wu Y, Belenkaya T, Lin X, 2011
The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling, Yan D, Wu Y, Feng Y, Lin S, Lin X, 2009
The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network, Belenkaya T, Wu Y, Tang X, Zhou B, Cheng L, Sharma Y, Yan D, Selva E, Lin X, 2008
DrosophilaDpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans, Belenkaya T, Han C, Yan D, Opoka R, Khodoun M, Liu H, Lin X, 2004
Dally cooperates with DrosophilaFrizzled 2 to transduce Wingless signalling, Lin X, Perrimon N, 1999

Developmental Genetics Stem Cell Biology Organoid Technology Mouse Models Signal Transduction Epigenetic Regulation Lung Homeostasis Tissue Repair Regeneration Translational Medicine

Xinhua Lin - Fudan University

Wu Wei - Tsinghua University

Shengtao Hou - Southern University of Science and Technology

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