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Leming Shi
Life Science
Fudan University
Shanghai
Language: English, Chinese
Chemical Genomics
Pharmacogenomics
Precision Medicine
Medical Big Data
Bioinformatics
Cheminformatics
Biomarkers
Disease Prevention
Diagnosis
Treatment
Areas of Focus
- Chemical Genomics
- Pharmacogenomics
- Precision Medicine
- Medical Big Data
- Bioinformatics
- Cheminformatics
Work Experience
- 1991-1993 - Assistant Researcher: Institute of Process Engineering, Chinese Academy of Sciences
- 1993-1994 - Associate Researcher: Institute of Process Engineering, Chinese Academy of Sciences
- 1994-1997 - Postdoctoral Researcher: Case Western Reserve University and NIH/NCI
- 1997-2001 - Various roles: FDA, Wyeth, and BASF in the USA
- 2001 - Co-founder: Shenzhen Chipscreen Biosciences
- 2003 - Rejoined FDA: Initiated MAQC/SEQC
- 2011 - Joined Fudan University: Professor at School of Life Sciences, Human Phenome Institute, and affiliated Cancer Hospital
Academic Background & Achievements
- 1985 - Bachelor's Degree in Analytical Chemistry: Hunan University
- 1988 - Master's Degree in Computational Chemistry: University of Science and Technology of China
- 1991 - Ph.D. in Computational Chemistry: Institute of Process Engineering, Chinese Academy of Sciences
- Published over 200 papers, including 15 in Nature Biotechnology
- h-index of 55 with over 13,000 citations
- Co-authored the book 'Big Data and Precision Medicine' (2017)
- Co-founded the International MAQC Society and served as its first president (2017-2018)
Publications
- Towards best practice in cancer mutation detection with whole-genome and whole-exome sequencing, Xiao W, Ren L, ..., Wang C, Shi L, 2021
- Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing, Fang LT, Zhu B, Zhao Y, ..., Hong H, Shi L, Wang C, Xiao W, 2021
- Genomic and transcriptomic landscape of triple-negative breast cancers: subtypes and treatment strategies, Jiang YZ, Ma D, Suo C, Shi J, Xue M, Hu X, ..., Wang P, Shi L, Huang W, Shao ZM, 2019
- The international MAQC Society launches to enhance reproducibility of high-throughput technologies, Shi L, ..., Tong W, 2017
- Telomerase activation by genomic rearrangements in high-risk neuroblastoma, Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, ..., Shi L, ..., Westermann F, Thomas RK, Fischer M, 2015
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequence Quality Control consortium, Su Z, Łabaj PP, Li S, ..., Kreil DP, Mason CE, Shi L, 2014
- The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models, Shi L, ..., Wolfinger RD, 2010
- Evaluation of external RNA controls for the assessment of microarray performance, Tong W, ..., Shi L, 2006
- Rat toxicogenomic study reveals analytical consistency across microarray platforms, Guo L, ..., Shi L, 2006
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements, Shi L, ..., Slikker W, Jr, 2006
Awards
- 2017 - Chinese Patent Gold Award (4th contributor)
- 2019 - Chief Scientist of National Key R&D Program 'Strategic International Scientific and Technological Innovation Cooperation'
