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Huan Zhang Zhu
Life Science
Fudan University
Shanghai
Language: Chinese, English
Hiv
Persistent Infection
Molecular Mechanisms
New Drugs
Biotherapies
Genetic Engineering
Gene Editing
Anti-Tumor
Immunotherapy
Research
Areas of Focus
- Molecular mechanisms of persistent HIV infection and development of new drugs and biotherapies against HIV infection
- Research on anti-tumor immunotherapy using genetic engineering and gene editing technologies
Work Experience
- 2003-present - Associate Professor/Doctoral Supervisor, Professor/Doctoral Supervisor: Fudan University, School of Life Sciences
Academic Background & Achievements
- 2000 - PhD in Medicine: Third Military Medical University
- 2005-2006 - Postdoctoral Research: University of British Columbia
- Led 15 national-level projects, including 4 major national projects and 8 National Natural Science Foundation projects
Publications
- Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5'-LTR promoter, Wang P, Qu X, Wang X, Zhu X, Zeng H, Chen H, Zhu HZ, 2014
- Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells, Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu HZ, 2013
- AS2O3 synergistically reactivate latent HIV-1 by induction of NF-kB, Wang PF, Qu Xy, Wang XH, Lin Liu, Zhu XL, Zeng HX, Zhu HZ, 2013
- Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation, Ding D, Qu X, Li L, Zhou X, Liu S, Lin S, Wang P, Liu S, Kong C, Wang X, Liu L, Zhu HZ, 2013
- Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB, Ying H, Zhang YH, Zhou X, Qu X, Kong C, Wang PF, Lu DR, Zhu HZ, 2012
Awards
- 2009-2010 - Fudan University School of Life Sciences Fosun Biopharmaceutical Teaching Award
