Professor | Bing Zhao | Asia Growth Partners

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Name	Bing Zhao
Contact Information	bingzhao@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Bing Zhao

Contact Information

bingzhao@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	2005-2008: Bachelor's Degree in Life Sciences, China Agricultural University 2008-2013: Ph.D. in Life Sciences, Tsinghua University 2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences 2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center 2017-present: Researcher, School of Life Sciences, Fudan University 2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University
Work Experience	2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences 2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center 2017-present: Researcher, School of Life Sciences, Fudan University 2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University
Awards	Fosun Pharma Teaching Award (First Class) (2020, 2021) National Excellent Youth Fund (2020) Oriental Scholar Distinguished Professor (2019) Shanghai Youth Top Talent (2018) Shanghai Youth Science and Technology Star (Category A) (2018) Dean's Award, School of Life Sciences (2018) AMGEN Postdoctoral Award (2015) Beijing Excellent Doctoral Graduate (2013)

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

2005-2008: Bachelor's Degree in Life Sciences, China Agricultural University
2008-2013: Ph.D. in Life Sciences, Tsinghua University
2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences
2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center
2017-present: Researcher, School of Life Sciences, Fudan University
2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University

Work Experience

2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences
2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center
2017-present: Researcher, School of Life Sciences, Fudan University
2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University

Awards

Fosun Pharma Teaching Award (First Class) (2020, 2021)
National Excellent Youth Fund (2020)
Oriental Scholar Distinguished Professor (2019)
Shanghai Youth Top Talent (2018)
Shanghai Youth Science and Technology Star (Category A) (2018)
Dean's Award, School of Life Sciences (2018)
AMGEN Postdoctoral Award (2015)
Beijing Excellent Doctoral Graduate (2013)

Areas of Focus	Mechanisms of adult stem cell fate determination using mouse genetics and organoid models Development of new strategies for organoid cultivation
Publications	Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver, Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B, 2022 Modeling human thyroid development by fetal tissue-derived organoid culture, Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B, 2022 Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis, Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B, 2022 Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression, Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B, Jiang N, Li R and Lin X, 2022 Emc3 maintains intestinal homeostasis by preserving secretory lineages, Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B and Lin X, 2021 Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis, Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B, Zheng X and Liu T, 2021 Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers, Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B, 2020 Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids, Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X, 2020 Generation of liver bipotential organoids with a small-molecule cocktail, Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B and Lin X, 2020 Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation, Zhao B, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X, 2019 Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors, Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X, Ling C and Zhao B, 2019 BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes, Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG, 2017 The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG, 2015 Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light, Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X, 2015 Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling, Cui HK, Zhao B, Li Y, Guo Y, Hu H, Liu L and Chen YG, 2013 PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG, 2012

Areas of Focus

Mechanisms of adult stem cell fate determination using mouse genetics and organoid models
Development of new strategies for organoid cultivation

Publications

Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver, Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B, 2022
Modeling human thyroid development by fetal tissue-derived organoid culture, Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B, 2022
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis, Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B, 2022
Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression, Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B, Jiang N, Li R and Lin X, 2022
Emc3 maintains intestinal homeostasis by preserving secretory lineages, Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B and Lin X, 2021
Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis, Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B, Zheng X and Liu T, 2021
Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers, Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B, 2020
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids, Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X, 2020
Generation of liver bipotential organoids with a small-molecule cocktail, Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B and Lin X, 2020
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation, Zhao B, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X, 2019
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors, Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X, Ling C and Zhao B, 2019
BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes, Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG, 2017
The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG, 2015
Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light, Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X, 2015
Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling, Cui HK, Zhao B, Li Y, Guo Y, Hu H, Liu L and Chen YG, 2013
PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG, 2012

Stem Cells Organoids Mouse Genetics Fate Determination Regenerative Biology Cultivation Strategies Adult Stem Cells Genetic Models Biological Research Developmental Biology

Ping Hu - University of Chinese Academy of Sciences

Ran Wang - Xi'an Jiaotong University

Ying Cao - Tongji University

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