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Bing Zhao
Life Science
Fudan University
Shanghai
Language: Chinese, English
Stem Cells
Organoids
Mouse Genetics
Fate Determination
Regenerative Biology
Cultivation Strategies
Adult Stem Cells
Genetic Models
Biological Research
Developmental Biology
Areas of Focus
- Mechanisms of adult stem cell fate determination using mouse genetics and organoid models
- Development of new strategies for organoid cultivation
Work Experience
- 2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences
- 2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center
- 2017-present: Researcher, School of Life Sciences, Fudan University
- 2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University
Academic Background & Achievements
- 2005-2008: Bachelor's Degree in Life Sciences, China Agricultural University
- 2008-2013: Ph.D. in Life Sciences, Tsinghua University
- 2013-2015: Postdoctoral Research, Tsinghua-Peking Joint Center for Life Sciences
- 2015-2017: Postdoctoral Research, Cincinnati Children's Hospital Medical Center
- 2017-present: Researcher, School of Life Sciences, Fudan University
- 2019-present: Dual-appointed Professor, Zhongshan Hospital, Fudan University
Publications
- Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver, Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B, 2022
- Modeling human thyroid development by fetal tissue-derived organoid culture, Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B, 2022
- Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis, Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B, 2022
- Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression, Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B, Jiang N, Li R and Lin X, 2022
- Emc3 maintains intestinal homeostasis by preserving secretory lineages, Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B and Lin X, 2021
- Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis, Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B, Zheng X and Liu T, 2021
- Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers, Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B, 2020
- Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids, Zhao B, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X, 2020
- Generation of liver bipotential organoids with a small-molecule cocktail, Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B and Lin X, 2020
- Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation, Zhao B, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X, 2019
- Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors, Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X, Ling C and Zhao B, 2019
- BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes, Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG, 2017
- The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells, Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG, 2015
- Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light, Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X, 2015
- Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling, Cui HK, Zhao B, Li Y, Guo Y, Hu H, Liu L and Chen YG, 2013
- PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG, 2012
Awards
- Fosun Pharma Teaching Award (First Class) (2020, 2021)
- National Excellent Youth Fund (2020)
- Oriental Scholar Distinguished Professor (2019)
- Shanghai Youth Top Talent (2018)
- Shanghai Youth Science and Technology Star (Category A) (2018)
- Dean's Award, School of Life Sciences (2018)
- AMGEN Postdoctoral Award (2015)
- Beijing Excellent Doctoral Graduate (2013)
