2004 - PhD: University of Science and Technology of China
2009 - Recruited under the 'Hundred Talents Program' by the Chinese Academy of Sciences
2014 - Awarded 'Outstanding Young Scientist' by the Chinese Academy of Sciences
2017 - Received funding from the National Natural Science Foundation of China
2004-2009 - Postdoctoral Researcher - University of Pennsylvania
2009-2014 - Researcher - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
2017-present - Distinguished Researcher - Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
2020-present - Professor - Fudan University
2014 - Outstanding Young Scientist by the Chinese Academy of Sciences
2017 - Funding from the National Natural Science Foundation of China
Research
Inter-organ communication and disease, especially interactions and remodeling between stomach and other organs like intestines, liver, and brain Gastrointestinal tumorigenesis and immune response Hippo signaling pathway regulation in tumorigenesis and immune response
Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells, Meng Y, Ye F, Nie P, Zhao Q, An L, Wang W, Qu S, Shen Z, Cao Z, Zhang X, et al., 2023
SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness, Jiao S, Li C, Guo F, Zhang J, Zhang H, Cao Z, Wang W, Bu W, Lin M, Lü J, et al., 2023
MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages, Cao JJ, Ji LL, Zhan YX, Shao X, Xu PC, Wu BT, Chen P, Cheng LY, Zhuang XB, Ou Y, et al., 2023
A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer, Nie P, Zhang W, Meng Y, Lin M, Guo F, Zhang H, et al., 2023
CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis, Guo Y, Zhu Z, Huang Z, Cui L, Yu W, Hong W, et al., 2022
Head-to-Tail Cross-Linking to Generate Bicyclic Helical Peptides with Enhanced Helicity and Proteolytic Stability, Chen K, Tang Y, Wu M, Wan XC, Zhang YN, Chen XX, et al., 2022
Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers, An L, Cao Z, Nie P, Zhang H, Tong Z, Chen F, et al., 2022
A Hippo's View: From Molecular Basis to Translational Medicine, Zhou Z, Yuan Z, Hong W, Wang W., 2021
An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, Zhang H, Lin M, Dong C, Tang Y, An L, Ju J, et al., 2021
A TNFR2-hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells, Meng Y, Zhao Q, An L, Jiao S, Li R, Sang Y, et al., 2021
Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer, Li G, Hu X, Nie P, Mang D, Jiao S, Zhang S, et al., 2021
Helix-Constrained Peptides Constructed by Head-to-Side Chain Cross-Linking Strategies, Chen XX, Tang Y, Wu M, Zhang YN, Chen K, Zhou Z, et al., 2021
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, An L, Nie P, Chen M, Tang Y, Zhang, H, Guan J, Cao Z, Hou C, Wang W, Zhao Y et al., 2020
Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling, Xu J, Tang Y, Sheng X, Tian Y, Deng M, Du S, Lv C, Li G, Pan Y, Song Y et al., 2020
Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, Tang Y, Chen M, Zhou L, Ma J, Li Y, Zhang H, Shi Z, Xu Q, Zhang X, Gao Z et al., 2019
TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts, Li Y, Guan J, Wang W, Hou C, Zhou L, Ma J, Cheng Y, Jiao S, Zhou Z., 2019
Targeting IRF3 as a YAP agonist therapy against gastric cancer, Jiao S, Guan J, Chen M, Wang W, Li C, Wang Y, Cheng Y, Zhou Z., 2018
The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer, Chen M, Zhang H, Shi Z, Li Y, Zhang X, Gao Z, Zhou L, Ma J, Xu Q, Guan J et al., 2018
DNA-binding mechanism of the Hippo pathway transcription factor TEAD4, Shi Z, He F, Chen M, Hua L, Wang W, Jiao S, Zhou Z., 2017
VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Jiao S, Li C, Hao Q, Miao H, Zhang L, Li L, Zhou Z., 2017
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-kappaB Signaling via Partial Degradation of the NF-kappaB Subunit p100, Zhang Z, Wang Y, Li C, Shi Z, Hao Q, Wang W, Song X, Zhao Y, Jiao S, Zhou Z., 2015
Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling, Shi Z, Zhang Z, Zhang Z, Wang Y, Li C, Wang X, He F, Sun L, Jiao S, Shi W et al., 2015
Structural dissection of Hippo signaling, Shi Z, Jiao S, Zhou Z., 2015
The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6, Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M et al., 2015
A non-canonical role of the p97 complex in RIG-I antiviral signaling, Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, Wang Y, Song X, Wang W, Zhang R et al., 2015
VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex, Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z et al., 2014
Structure of MST2 SARAH domain provides insights into its interaction with RAPL, Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Zhang M, Feng M, Xu L et al., 2014
Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1, Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z., 2014
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer, Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, He F, Wang Y, Zhang Z, Wang W et al., 2014
Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2: 2 Heterotetrameric Core of Striatin- interacting Phosphatase and Kinase ( STRIPAK) Complex, Chen CC, Shi ZB, Zhang WQ, Chen M, He F, Zhang ZZ, Wang YC, Feng M, Wang WJ, Zhao Y et al., 2014
Structural mechanism of CCM3 heterodimerization with GCKIII kinases, Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q et al., 2013
Structure of the MST4 in complex with MO25 provides insights into its activation mechanism, Shi Z, Jiao S, Zhang Z, Ma M, Zhang Z, Chen C, Wang K, Wang H, Wang W, Zhang L et al., 2013
Structural insights into SUN-KASH complexes across the nuclear envelope, Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z., 2012
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function, Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z et al., 2012
