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Shimin Zhao
Life Science
Fudan University
Shanghai
Language: Chinese, English
Metabolism
Regulation
Disorders
Human Diseases
Acetylation
Enzymes
Tumor
Intervention
Biochemistry
Proteomics
Areas of Focus
- Metabolic regulation mechanisms and the relationship between metabolic disorders and human diseases
- Mechanisms of human diseases caused by metabolic enzyme acetylation disorders and new intervention methods
- Mechanisms of tumor occurrence caused by metabolic intermediate disorders and intervention methods
Work Experience
- 1988-1995 - Chinese Academy of Medical Sciences - Researcher
- 2000-2005 - Procter & Gamble - Various roles
- 2006-present - Fudan University - Associate Researcher/Professor, Doctoral Supervisor
Academic Background & Achievements
- 1984-1988 Bachelor's Degree: Beijing Normal University, Chemistry
- 2000 Ph.D.: Purdue University, Biochemistry
- Changjiang Scholar Distinguished Professor
Publications
- Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase., Wenqing Jiang, Shiwen Wang, Mengtao Xiao, Yan Lin, Lisha Zhou, Qunying Lei, Yue Xiong, Kun-Liang Guan and Shimin Zhao, 2011
- Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α- ketoglutarate-dependent dioxygenases., Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, Ito S, Yang C, Wang P, Xiao M, Liu L, Jiang W, Liu J, Zhang J, Wang B, Frye S, Zhang Y, Xu Y, Lei Q, Guan K, Zhao S and Y. Xiong, 2011
- Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux., Qijun Wang, Yakun Zhang, Hui Xiong, Yan Lin, Hong Li, Lu Xie, Wei Zhao, Yufeng Yao, Yue Xiong, Kun-Liang Guan, Shimin Zhao and Guo-Ping Zhao, 2010
- Regulation of Cellular Metabolism by Protein Lysine Acetylation., Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Pengyuan Yang, Hong Li, Yixue Li, Jiong Shi, Lunxiu Qin, Qunying Lei, Yue Xiong and Kun-Liang Guan, 2010
- Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a., Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, Yue Xiong, 2009
Awards
- 2012: First Prize in Natural Science by the Ministry of Education (First Contributor)
- 2010: Top Ten Scientific and Technological Progress in Chinese Universities
- 2010: Top Ten Scientific Progress in China
- Tan Jiazhen Life Science Innovation Award
- Meiji Life Science Research Excellence Award
