Professor | Shimin Zhao | Asia Growth Partners

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Name	Shimin Zhao
Contact Information	zhaosm@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Shimin Zhao

Contact Information

zhaosm@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Life Sciences
Academic Background & Achievements	1984-1988 Bachelor's Degree: Beijing Normal University, Chemistry 2000 Ph.D.: Purdue University, Biochemistry Changjiang Scholar Distinguished Professor
Work Experience	1988-1995 - Chinese Academy of Medical Sciences - Researcher 2000-2005 - Procter & Gamble - Various roles 2006-present - Fudan University - Associate Researcher/Professor, Doctoral Supervisor
Awards	2012: First Prize in Natural Science by the Ministry of Education (First Contributor) 2010: Top Ten Scientific and Technological Progress in Chinese Universities 2010: Top Ten Scientific Progress in China Tan Jiazhen Life Science Innovation Award Meiji Life Science Research Excellence Award

University/Lab Affiliation and Title

Fudan University

Faculty

Life Sciences

Academic Background & Achievements

1984-1988 Bachelor's Degree: Beijing Normal University, Chemistry
2000 Ph.D.: Purdue University, Biochemistry
Changjiang Scholar Distinguished Professor

Work Experience

1988-1995 - Chinese Academy of Medical Sciences - Researcher
2000-2005 - Procter & Gamble - Various roles
2006-present - Fudan University - Associate Researcher/Professor, Doctoral Supervisor

Awards

2012: First Prize in Natural Science by the Ministry of Education (First Contributor)
2010: Top Ten Scientific and Technological Progress in Chinese Universities
2010: Top Ten Scientific Progress in China
Tan Jiazhen Life Science Innovation Award
Meiji Life Science Research Excellence Award

Areas of Focus	Metabolic regulation mechanisms and the relationship between metabolic disorders and human diseases Mechanisms of human diseases caused by metabolic enzyme acetylation disorders and new intervention methods Mechanisms of tumor occurrence caused by metabolic intermediate disorders and intervention methods
Publications	Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase., Wenqing Jiang, Shiwen Wang, Mengtao Xiao, Yan Lin, Lisha Zhou, Qunying Lei, Yue Xiong, Kun-Liang Guan and Shimin Zhao, 2011 Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α- ketoglutarate-dependent dioxygenases., Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, Ito S, Yang C, Wang P, Xiao M, Liu L, Jiang W, Liu J, Zhang J, Wang B, Frye S, Zhang Y, Xu Y, Lei Q, Guan K, Zhao S and Y. Xiong, 2011 Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux., Qijun Wang, Yakun Zhang, Hui Xiong, Yan Lin, Hong Li, Lu Xie, Wei Zhao, Yufeng Yao, Yue Xiong, Kun-Liang Guan, Shimin Zhao and Guo-Ping Zhao, 2010 Regulation of Cellular Metabolism by Protein Lysine Acetylation., Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Pengyuan Yang, Hong Li, Yixue Li, Jiong Shi, Lunxiu Qin, Qunying Lei, Yue Xiong and Kun-Liang Guan, 2010 Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a., Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, Yue Xiong, 2009

Areas of Focus

Metabolic regulation mechanisms and the relationship between metabolic disorders and human diseases
Mechanisms of human diseases caused by metabolic enzyme acetylation disorders and new intervention methods
Mechanisms of tumor occurrence caused by metabolic intermediate disorders and intervention methods

Publications

Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase., Wenqing Jiang, Shiwen Wang, Mengtao Xiao, Yan Lin, Lisha Zhou, Qunying Lei, Yue Xiong, Kun-Liang Guan and Shimin Zhao, 2011
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α- ketoglutarate-dependent dioxygenases., Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, Ito S, Yang C, Wang P, Xiao M, Liu L, Jiang W, Liu J, Zhang J, Wang B, Frye S, Zhang Y, Xu Y, Lei Q, Guan K, Zhao S and Y. Xiong, 2011
Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux., Qijun Wang, Yakun Zhang, Hui Xiong, Yan Lin, Hong Li, Lu Xie, Wei Zhao, Yufeng Yao, Yue Xiong, Kun-Liang Guan, Shimin Zhao and Guo-Ping Zhao, 2010
Regulation of Cellular Metabolism by Protein Lysine Acetylation., Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Pengyuan Yang, Hong Li, Yixue Li, Jiong Shi, Lunxiu Qin, Qunying Lei, Yue Xiong and Kun-Liang Guan, 2010
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a., Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qunying Lei, Kun-Liang Guan, Yue Xiong, 2009

Metabolism Regulation Disorders Human Diseases Acetylation Enzymes Tumor Intervention Biochemistry Proteomics

Shimin Zhao - Fudan University

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

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