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Chunlin Shao
Radiation Medicine
Fudan University
Shanghai
Language: English, Chinese, Japanese
Ultra-High Dose Rate Radiation
Flash Effect
Radiation Biology
Radiation Signaling Pathways
Tumor Radioimmunology
Molecular Mechanisms
Radiation Resistance
Immune Microenvironment
Bystander Effects
Distal Effects
Areas of Focus
- Ultra-high dose rate radiation (FLASH) effect
- Molecular mechanisms of tumor radioimmunology
- Radiation bystander and distal effects
Academic Background & Achievements
- Ph.D.: Kyoto University, Japan
- Research: National Institute of Radiological Sciences, Japan
- Research: Gray Institute for Radiation Oncology and Biology, University of Oxford, UK
- Published over 220 papers, including more than 130 SCI papers
- Shanghai Science and Technology Progress Award (First and Second Prize)
- Shanghai Excellent Invention Gold Award
- Third Prize of the Chinese Preventive Medicine Association Science and Technology Award
- Second Prize of the Shanghai Medical Science and Technology Award
- Second Prize of the Chinese Academy of Sciences Natural Science Award
Publications
- FLASH X-ray spares intestinal crypts from pyroptosis initiated by cGAS-STING activation upon radioimmunotherapy, Xiaolin Shi, Yiwei Yang, Wei Zhang, Jianxin Wang, Dexin Xiao, Huangge Ren, Tingting Wang, Feng Gao, Zhen Liu, Kui Zhou, Peng Li, Zheng Zhou, Peng Zhang, Xuming Shen, Yu Liu, Jianheng Zhao, Zhongmin Wang, Fenju Liu, Chunlin Shao, Dai Wu, Haowen Zhang, 2022
- GDF15 contributes to radioresistance by mediating the EMT and stemness of breast cancer cells, Xinrui Zhao, Xinglong Liu, Songling Hu, Yan Pan, Jianghong Zhang, Guomei Tai, Chunlin Shao, 2022
- Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment, Yuhong Zhang, Xinglong Liu, Liang Zeng, Xinrui Zhao, Qianping Chen, Yan Pan, Yang Bai, Chunlin Shao, Jianghong Zhang, 2022
- SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma, Qianping Chen, Wang Zheng, Jian Guan, Hongxia Liu, Yao Dan, Lin Zhu, Yimeng Song, Yuchuan Zhou, Xinrui Zhao, Yuhong Zhang, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao, 2022
- SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes, Wang Zheng, Qianping Chen, Hongxia Liu, Liang Zeng, Yuchuan Zhou, Xinglong Liu, Yang Bai, Jianghong Zhang, Yan Pan, Chunlin Shao, 2022
- Irradiation combined with PD-L1-/- and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated Tcell activation, Xinrui Zhao, Songling Hu, Liang Zeng, Xinglong Liu, Yimeng Song, Yuhong Zhang, Qianping Chen, Yang Bai, Jianghong Zhang, Haowen Zhang, Yan Pan, Chunlin Shao, 2022
- Promising Biomarkers of Radiation-Induced Lung Injury: A Review, Xinglong Liu, Chunlin Shao, Jiamei Fu, 2021
- MMP14 contributes to HDAC inhibition-induced radiosensitization of glioblastoma, Yuchuan Zhou, Hongxia Liu, Wang Zheng, Qianping Chen, Songling Hu, Yan Pan, Yang Bai, Jianghong Zhang, Chunlin Shao, 2021
- Fractionated irradiation of right thorax induces abscopal damage on bone marrow cells via TNF-α and SAA, Yimeng Song, Songling Hu, Junling Zhang, Lin Zhu, Xinrui Zhao, Qianping Chen, Jianghong Zhang, Yang Bai, Yan Pan, Chunlin Shao, 2021
- LACTB2 Renders Radioresistance by Activating PINK1/Parkin-dependent Mitophagy in Nasopharyngeal Carcinoma Cells, Qianping Chen, Wang Zheng, Lin Zhu, Hongxia Liu, Yimeng Song, Songling Hu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao, 2021
- CD81 enhances radioresistance of glioblastoma by promoting nuclear translocation of Rad51, Wang Zheng, Qianping Chen, Hongxia Liu, Songling Hu, Yuchuan Zhou, Yang Bai, Jianghong Zhang, Yan Pan, Chunlin Shao, 2021
- The roles of HIF-1α in radiosensitivity and radiation induced bystander effects under hypoxia, Jianghong Zhang, Yuhong Zhang, Fang Mo, Gaurang Patel, Karl T Butterworth, Chunlin Shao, Kevin Prise, 2021
- Radiation-induced abscopal reproductive effect is driven by Rac1 nuclear translocation in Sertoli cells, Songling Hu, Lin Zhu, Yimeng Song, Xinrui Zhao, Qianping Chen, Yan Pan, Jianghong Zhang, Yang Bai, Haowen Zhang, Chunlin Shao, 2021
- Roles of macrophage in radiation-induced abscopal effect via TNF-α in breast cancer, Lin Zhu, Songling Hu, Qianping Chen, Jiamei Fu, Haowen Zhang, Junling Zhang, Yan Pan, Yang Bai, Chunlin Shao, 2021
- LncRNA CASC19 contributes to radioresistance of nasopharyngeal carcinoma by promoting autophagy via AMPK-mTOR pathway, Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao, 2021
- Histone methylation can either promote or reduce cellular radiosensitivity by regulating DNA repair pathways, Yuchuan Zhou, Chunlin Shao, 2021
- Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway, Han Pan, Yimeng Song, Hang Zhang, Yang Bai, Teruaki Konishi, Alisa Kobayashi, Yan Pan, Chunlin Shao, 2021
- Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade, Xinrui Zhao, Chunlin Shao, 2020
- CDK6 inhibition targeted by miR-378a-3p protects against intestinal injury induced by ionizing radiation, Xiaofei Chu, Wang Zheng, Juan Wang, Jianghong Zhang, Yan Pan, Chunlin Shao, 2020
- Induction of TIGAR accelerates reserve intestinal stem cell division and mitigates lethal gastrointestinal syndrome induced by radiation, Fei Chen, Yushuo Zhang, Songling Hu, Xiaolin Shi, Zhongmin Wang, Zicheng Deng, Jianghong Zhang, Yan Pan, Yang Bai, Fenju Liu, Haowen Zhang, Chunlin Shao, 2020
- CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation, Lin Zhu, Qianping Chen, Longshan Zhang, Songling Hu, Wang Zheng, Chen Wang, Yang Bai, Yan Pan, Teruaki Konishi, Jian Guan, Chunlin Shao, 2020
- Exosomes from irradiated lung cancer cells carrying ALDOA and ALDH3A1 enhance migration and invasion of recipients by accelerating glycolysis, Chen Wang, Jinping Xu, Dexiao Yuan, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao, 2020
- Effects of hypoxia and radiation-induced exosomes on migration of lung cancer cells and angiogenesis of umbilical vein endothelial cells, Fang Mo, Yanwu Xu, Junling Zhang, Lin Zhu, Chen Wang, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao, Jianghong Zhang, 2020
- Inhibition of Cathepsin D (CTSD) enhances radiosensitivity in glioblastoma cells through attenuated autophagy, Wang Zheng, Qianping Chen, Chen Wang, Xiaofei Chu, Dan Yao, Lin Zhu, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao, 2020
- ANXA6 contributes to radioresistance by regulating cell autophagy and migration in nasopharyngeal carcinoma, Qianping Chen, Wang Zheng, Lin Zhu, Dan Yao, Junling Zhang, Chen Wang, Fang Mo, Yimeng Song, Hongxia Liu, Songling Hu, Xiaofei Chu, Yang Bai, Yan Pan, Jianghong Zhang, Chunlin Shao, 2020
- Macrophage-mediated secondary bystander effects after different radiations through a p53-dependent pathway, Jiamei Fu, Lin Zhu, Wenzhi Tu, Xiangdong Wang, Yan Pan, Yang Bai, Bingrong Dang, Jieyi Chen, Chunlin Shao, 2020
- Role of endoplasmic reticulum and mitochondrion in proton microbeam-irradiation induced bystander effect, Chen Dong, Wenzhi Tu, Mingyuan He, Jiamei Fu, Alisa Kobayashi, Yoshiya Furusawa, Teruaki Konishi, Chunlin Shao, 2019
- Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State, Fei Guo, Dexiao Yuan, Junling Zhang, Hang Zhang, Chen Wang, Lin Zhu, Jianghong Zhang, Yan Pan, Chunlin Shao, 2019
- Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility, Junling Zhang, Dan Yao, Yimeng Song, Yan Pan, Lin Zhu, Yang Bai, Yanwu Xu, Jianghong Zhang, Chunlin Shao, 2019
- TGF-β mediates thoracic radiation-induced abscopal effects of testis injury in rat, Junling Zhang, Dan Yao, Jianghong Zhang, Yimeng Song, Fang Mo, Xiaofei Chu, Yan Pan, Yang Bai, Chunlin Shao, 2019
- Autophagy suppresses radiation damage by activating PARP-1 and attenuating reactive oxygen species in hepatoma cells
Awards
- Shanghai Science and Technology Progress Award (First and Second Prize)
- Shanghai Excellent Invention Gold Award
- Third Prize of the Chinese Preventive Medicine Association Science and Technology Award
- Second Prize of the Shanghai Medical Science and Technology Award
- Second Prize of the Chinese Academy of Sciences Natural Science Award
