1979.09-1983.07 Bachelor's Degree: Hangzhou University
1989.10-1993.07 PhD: The Australian National University
Achievement: Published 253 original research papers in top journals like Cell, JCI, Am J Hum Genet, Nucleic Acid Res, Circulation Res
Achievement: Selected as 'Highly Cited Researcher' in Biochemistry, Genetics, and Molecular Biology by Elsevier for 9 consecutive years (2014-2022)
1983.08-1989.09 - Zhejiang Library - Librarian
1993.08-1999.07 - California Institute of Technology - Research Fellow, Senior Research Fellow
1999.08-2011.09 - Cincinnati Children's Hospital Medical Center - Assistant Professor, Associate Professor, Professor of Human Genetics
2011.01-present - Zhejiang University - Qiushi Chair Professor, Director of the Institute of Genetics
2011.01-2013.11 - Zhejiang University - Dean of the School of Life Sciences
2015.04-2022.05 - Zhejiang University - Deputy Director of the Medical School
2015.11-present - Zhejiang University-University of Toronto Joint Institute of Genetics and Genomic Medicine - Director
Tan Jiazhen Life Science Innovation Award (2012)
National Science and Technology Progress Award Second Prize (2007, 2008)
Chinese Medical Science and Technology Award Second Prize (2009)
Zhejiang Provincial Science and Technology First Prize (2009, 2015)
Research
Mitochondrial Molecular Genetics and Pathogenesis of Maternal Inherited Diseases Genetic Mechanisms of Deafness Leber's Hereditary Optic Neuropathy Primary Hypertension tRNA Base Modification Mechanisms and Their Role in Mitochondrial Diseases
Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy, Nie N, Wang C, Chen J, Ji Y, Zhang H, Zhao F, Zhou X, Guan MX, 2023
Nuclear modifier YARS2 allele correction restored retinal ganglion cells-specific deficiencies in Leber's hereditary optic neuropathy, Chen JR, Chen C, Chen J, Ji Y, Lian Y, Zhang J, Yu J, Li XY, Qu J, Guan MX, 2023
A deafness-associated mitochondrial DNA mutation caused pleiotropic effects on DNA replication and tRNA metabolism, Meng F, Jia Z, Zheng J, Ji Y, Wang J, Xiao Y, Fu Y, Wang M, Feng Ling F, Guan MX, 2022
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro, Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX, 2022
A deafness-associated tRNA mutation caused pleiotropic effects on the m1G37 modification, processing, stability and aminoacylation of tRNAIle and mitochondrial translation, Meng F, Zhou M, Xiao Y, Mao X, Zheng J, Lin J, Lin T, Ye Z, Cang X, Fu Y, Wang M, Guan MX, 2021
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency, Zhang, Q., He, X., Yao, S., Lin, T., Zhang, L., Chen, D., Chen, C., Yang, Q., Li, F., Zhu, Y.M. and Guan, M.X., 2021
PRICKLE3 Linked to ATPase Biogenesis Manifested Leber's Hereditary Optic Neuropathy, Yu J, Liang X, Ji Y, Ai C, Liu J, Zhu L, Nie Z, Jin X, Wang C, Zhang J, Zhao F, Mei S, Zhao X, Zhou X, Zhang M, Wang M, Huang T, Jiang P, Guan MX, 2020
Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts, Xiao, Y.,Wang, M., He, Q., Xu, L., Zhang, Q., Meng, F.，Jia, Z., Zhang, F., Wang, H., Guan, M.X, 2020
A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis, Jia Z, Zhang Y, Li Q, Ye Z, Liu Y, Fu C, Cang X, Wang M, Guan MX, 2019
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism, Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX, 2019
Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNAMet, all 8 tRNAs and ND6 mRNA in the light-strand transcript, Zhao X, Cui L, Xiao Y, Mao Q, Aishanjiang M, Kong W, Liu Y, Chen H, Hong F, Jia Z, Wang M, Jiang P, Guan MX, 2019
Deletion of Mtu1 (Trmu) in Zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function, Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX, 2018
A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function, Zhou M, Xue L, Chen Y, Li H, He Q, Wang B, Meng F, Wang M, Guan MX, 2018
The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation, Jiang P, Jin X, Peng Y, Wang M, Liu H, Liu X, Zhang Z, Ji Y, Zhang J, Liang M, Zhao F, Sun YH, Zhang M, Zhou X, Chen Y, Mo JQ, Huang T, Qu J, and Guan MX, 2016
A deafness-associated tRNAAsp mutation alters the m1G37 modification, aminoacylation and stability of tRNAAsp and mitochondrial function, Wang M, Peng Y, Zheng J, Zheng B, Jin X, Liu H, Wang Y, Tang X, Huang T, Jiang P, Guan MX, 2016
A deafness-associated tRNAHis mutation alters the mitochondrial function, ROS production and membrane potential, Gong S, Peng Y, Jiang P, Wang M, Fan M, Wang X, Zhou H, Li H, Yan Q, Huang T, Guan MX, 2014
Maternally inherited essential hypertension is associated with the novel 4263A>G mutation in the mitochondrial tRNAIle gene in a large Han Chinese family, Wang S, Li R, Fettermann A, Li Z, Liu Y, Wang X, Zhou A, Yang L, Taschner A, Rossmanit W, Guan MX, 2011
Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations, Guan, M.X, Yan, Q., Li, X., Bykhovskaya, Y., Gallo-Teran, J., Hajek, P., Umeda, N., Zhao, H., Garrido, G., Mengesha, M., Suzuki, T., del Castillo, I., Peters, J.L., Li, R., Qian, Y., Wang, X., Ballana, E., M. Shohat, Lu, J., Estivill, X., Watanabe, K., Fischel-Ghodsian, N., 2006
Maternally inherited aminoglycoside-induced and non-syndromic deafness is associated with the novel C1494T mutation in the mitochondrial 12S rRNA gene in a large Chinese family, Zhao, H., Li, R., Wang, Q., Yan, Q., Deng, J.H., Han, D., Bai, Y., Young, W.Y., Guan, M.X, 2004
