Professor | Maode Lai | Asia Growth Partners

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Name	Maode Lai
Contact Information	lmd@zju.edu.cn
Language ability	Chinese, English, German
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Maode Lai

Contact Information

lmd@zju.edu.cn

Language ability

Chinese, English, German

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	Academician of the German Academy of Sciences Professor of Pathology at Zhejiang University Chief Physician Double-appointed Professor at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Vice Chairman of the Chinese Pharmaceutical Association Deputy Director of the National (Ministry of Education) Basic Medical Education Steering Committee Former Vice President of Zhejiang Medical University Former Vice President of Zhejiang University Former Chairman of the Pathology Society of the Chinese Medical Association Former Vice President of the Pathologist Branch of the Chinese Medical Doctor Association
Awards	1988: Second Prize of the Ministry of Health Science and Technology Progress Award for the study on the effects of air pollutants on alveolar macrophages (Second Contributor) 2005: First Prize of Zhejiang Science and Technology Award for the construction of a molecular pathology research platform and screening of biomarkers related to colorectal cancer (First Contributor) 2011: First Prize of Zhejiang Science and Technology Award for the identification and application of diagnostic and prognostic markers for colorectal cancer (First Contributor)

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

Academician of the German Academy of Sciences
Professor of Pathology at Zhejiang University
Chief Physician
Double-appointed Professor at Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Vice Chairman of the Chinese Pharmaceutical Association
Deputy Director of the National (Ministry of Education) Basic Medical Education Steering Committee
Former Vice President of Zhejiang Medical University
Former Vice President of Zhejiang University
Former Chairman of the Pathology Society of the Chinese Medical Association
Former Vice President of the Pathologist Branch of the Chinese Medical Doctor Association

Awards

1988: Second Prize of the Ministry of Health Science and Technology Progress Award for the study on the effects of air pollutants on alveolar macrophages (Second Contributor)
2005: First Prize of Zhejiang Science and Technology Award for the construction of a molecular pathology research platform and screening of biomarkers related to colorectal cancer (First Contributor)
2011: First Prize of Zhejiang Science and Technology Award for the identification and application of diagnostic and prognostic markers for colorectal cancer (First Contributor)

Areas of Focus	Tumor Pathology Digital Pathology and Artificial Intelligence
Publications	MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells, Zhang H, Tang J, Li C, Kong J, Wang J, Wu Y, Xu E, Lai M, 2015 IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer, Zhu S, Zhang J, Xu F, Xu E, Ruan W, Ma Y, Huang Q, Lai M, 2015 Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population, Liu Y, Wu M, Ling J, Cai L, Zhang D, Gu HF, Wang H, Zhu Y, Lai M, 2015 Epithelial-mesenchymal transition in colorectal cancer metastasis: A system review, Cao H, Xu E, Liu H, Wan L, Lai M, 2015 Binding-Induced DNA Nanomachines Triggered by Proteins and Nucleic Acids, Zhang H, Lai M, Zuehlke A, Peng H, Li XF, Le XC, 2015 Molecular mechanisms of microRNAs in regulating epithelial-mesenchymal transitions in human cancers, Tang J, Li Y, Wang J, Wen Z, Lai M, Zhang H, 2015 Sox9 Regulates Self-Renewal and Tumorigenicity by Promoting Symmetrical Cell Division of Cancer Stem Cells in Hepatocellular Carcinoma, Liu C, Liu L, Chen X, Cheng J, Zhang H, Shen J, Shan J, Xu Y, Yang Z, Lai M, Qian C, 2016 Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer, Wu J, Wang Y, Xu X, Cao H, Sahengbieke S, Sheng H, Huang Q, Lai M, 2016 Interaction between IGFBP7 and insulin: a theoretical and experimental study, Ruan W, Kang Z, Li Y, Sun T, Wang L, Liang L, Lai M, Wu T, 2016 Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6, Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H, Lai M, 2016 SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells, Liu L, Liu C, Zhang Q, Shen J, Zhang H, Shan J, Duan G, Guo D, Chen X, Cheng J, Xu Y, Yang Z, Yao C, Lai M, Qian C, 2016 A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese, Xu C, Zhou D, Pan F, Liu Y, Zhang D, Lin A, Miao X, Ni Y, Lv D, Zhang S, Li X, Zhu Y, Lai M, 2016 Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-kappaB-dependent activation of snail and epithelial mesenchymal transition, Feng M, Feng J, Chen W, Wang W, Wu X, Zhang J, Xu F, Lai M, 2016 ATG16L1 rs2241880 polymorphism predicts unfavorable clinical outcomes for colorectal cancer patients in the Chinese population, Cao H, Li ZL, Zhou D, Wan LD, Yu D, Zhang J, Xu EP, Zhang DD, Lai MD, 2016 Association of TET1 expression with colorectal cancer progression, Tian Y, Pan F, Sun X, Gan M, Lin A, Zhang D, Zhu Y, Lai M, 2017 S100A8+ stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma, Li S, Xu F, Li H, Zhang J, Zhong A, Huang B, Lai M, 2017 Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study, Zhu Y, Zhang D, Zhou D, Li Z, Li Z, Fang L, Yang M, Shan Z, Li H, Chen J, Zhou X, Ye W, Yu S, Li H, Cai L, Liu C, Zhang J, Wang L, Lai Y, Ruan L, Sun Z, Zhang S, Wang H, Liu Y, Xu Y, Ling J, Xu C, Zhang Y, Lv D, Yuan Z, Zhang J, Zhang Y, Shi Y, Lai M, 2017 The integrated pathway of TGFbeta/Snail with TNFalpha/NFkappaB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis, Li H, Zhong A, Li S, Meng X, Wang X, Xu F, Lai M, 2017 Deletions at SLC18A1 increased the risk of CRC and lower SLC18A1 expression associated with poor CRC outcome, Zhang D, Li Z, Xu X, Zhou D, Tang S, Yin X, Xu F, Li H, Zhou Y, Zhu T, Deng H, Zhang S, Huang Q, Wang J, Yin W, Zhu Y, Lai M, 2017 SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer, Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Wu Y, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H, Lai M, 2017 Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer, Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, Yu D, Tian Y, Jin H, Lin A, Gao F, Lai M, 2018 Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma, Li S, Xu F, Zhang J, Wang L, Zheng Y, Wu X, Wang J, Huang Q, Lai M, 2018 The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study, Zhang D, Yang M, Zhou D, Li Z, Cai L, Bao Y, Li H, Shan Z, Liu J, Lv D, Liu Y, Xu C, Ling J, Xu Y, Zhang S, Huang Q, Shi Y, Zhu Y, Lai M, 2018 TSVdb: a web-tool for TCGA splicing variants analysis, Sun W, Duan T, Ye P, Chen K, Zhang G, Lai M, Zhang H, 2018

Areas of Focus

Tumor Pathology
Digital Pathology and Artificial Intelligence

Publications

MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells, Zhang H, Tang J, Li C, Kong J, Wang J, Wu Y, Xu E, Lai M, 2015
IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer, Zhu S, Zhang J, Xu F, Xu E, Ruan W, Ma Y, Huang Q, Lai M, 2015
Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population, Liu Y, Wu M, Ling J, Cai L, Zhang D, Gu HF, Wang H, Zhu Y, Lai M, 2015
Epithelial-mesenchymal transition in colorectal cancer metastasis: A system review, Cao H, Xu E, Liu H, Wan L, Lai M, 2015
Binding-Induced DNA Nanomachines Triggered by Proteins and Nucleic Acids, Zhang H, Lai M, Zuehlke A, Peng H, Li XF, Le XC, 2015
Molecular mechanisms of microRNAs in regulating epithelial-mesenchymal transitions in human cancers, Tang J, Li Y, Wang J, Wen Z, Lai M, Zhang H, 2015
Sox9 Regulates Self-Renewal and Tumorigenicity by Promoting Symmetrical Cell Division of Cancer Stem Cells in Hepatocellular Carcinoma, Liu C, Liu L, Chen X, Cheng J, Zhang H, Shen J, Shan J, Xu Y, Yang Z, Lai M, Qian C, 2016
Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer, Wu J, Wang Y, Xu X, Cao H, Sahengbieke S, Sheng H, Huang Q, Lai M, 2016
Interaction between IGFBP7 and insulin: a theoretical and experimental study, Ruan W, Kang Z, Li Y, Sun T, Wang L, Liang L, Lai M, Wu T, 2016
Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6, Kong J, Sun W, Li C, Wan L, Wang S, Wu Y, Xu E, Zhang H, Lai M, 2016
SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells, Liu L, Liu C, Zhang Q, Shen J, Zhang H, Shan J, Duan G, Guo D, Chen X, Cheng J, Xu Y, Yang Z, Yao C, Lai M, Qian C, 2016
A novel variant on chromosome 6p21.1 is associated with the risk of developing colorectal cancer: a two-stage case-control study in Han Chinese, Xu C, Zhou D, Pan F, Liu Y, Zhang D, Lin A, Miao X, Ni Y, Lv D, Zhang S, Li X, Zhu Y, Lai M, 2016
Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-kappaB-dependent activation of snail and epithelial mesenchymal transition, Feng M, Feng J, Chen W, Wang W, Wu X, Zhang J, Xu F, Lai M, 2016
ATG16L1 rs2241880 polymorphism predicts unfavorable clinical outcomes for colorectal cancer patients in the Chinese population, Cao H, Li ZL, Zhou D, Wan LD, Yu D, Zhang J, Xu EP, Zhang DD, Lai MD, 2016
Association of TET1 expression with colorectal cancer progression, Tian Y, Pan F, Sun X, Gan M, Lin A, Zhang D, Zhu Y, Lai M, 2017
S100A8+ stroma cells predict a good prognosis and inhibit aggressiveness in colorectal carcinoma, Li S, Xu F, Li H, Zhang J, Zhong A, Huang B, Lai M, 2017
Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study, Zhu Y, Zhang D, Zhou D, Li Z, Li Z, Fang L, Yang M, Shan Z, Li H, Chen J, Zhou X, Ye W, Yu S, Li H, Cai L, Liu C, Zhang J, Wang L, Lai Y, Ruan L, Sun Z, Zhang S, Wang H, Liu Y, Xu Y, Ling J, Xu C, Zhang Y, Lv D, Yuan Z, Zhang J, Zhang Y, Shi Y, Lai M, 2017
The integrated pathway of TGFbeta/Snail with TNFalpha/NFkappaB may facilitate the tumor-stroma interaction in the EMT process and colorectal cancer prognosis, Li H, Zhong A, Li S, Meng X, Wang X, Xu F, Lai M, 2017
Deletions at SLC18A1 increased the risk of CRC and lower SLC18A1 expression associated with poor CRC outcome, Zhang D, Li Z, Xu X, Zhou D, Tang S, Yin X, Xu F, Li H, Zhou Y, Zhu T, Deng H, Zhang S, Huang Q, Wang J, Yin W, Zhu Y, Lai M, 2017
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer, Wan L, Yu W, Shen E, Sun W, Liu Y, Kong J, Wu Y, Han F, Zhang L, Yu T, Zhou Y, Xie S, Xu E, Zhang H, Lai M, 2017
Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer, Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, Yu D, Tian Y, Jin H, Lin A, Gao F, Lai M, 2018
Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma, Li S, Xu F, Zhang J, Wang L, Zheng Y, Wu X, Wang J, Huang Q, Lai M, 2018
The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study, Zhang D, Yang M, Zhou D, Li Z, Cai L, Bao Y, Li H, Shan Z, Liu J, Lv D, Liu Y, Xu C, Ling J, Xu Y, Zhang S, Huang Q, Shi Y, Zhu Y, Lai M, 2018
TSVdb: a web-tool for TCGA splicing variants analysis, Sun W, Duan T, Ye P, Chen K, Zhang G, Lai M, Zhang H, 2018

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