Professor | Peidong Han | Asia Growth Partners

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Name	Peidong Han
Contact Information	hanpd@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Peidong Han

Contact Information

hanpd@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2000-2004 Bachelor's Degree in Biological Sciences: Nankai University 2004-2009 Ph.D. in Biophysics: Peking University Achievement: Discovered the role of Notch signaling in cardiac development (Nature) Achievement: Revealed the mechanism of hydrogen peroxide in heart regeneration (Cell Research) Achievement: Identified the role of Ptpn23 gene in cardiac diseases (Circulation)
Work Experience	2009-2011 - Peking University - Postdoctoral Researcher 2011-2017 - University of California, San Diego - Postdoctoral/Assistant Project Scientist 2018-Present - Zhejiang University - Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2000-2004 Bachelor's Degree in Biological Sciences: Nankai University
2004-2009 Ph.D. in Biophysics: Peking University
Achievement: Discovered the role of Notch signaling in cardiac development (Nature)
Achievement: Revealed the mechanism of hydrogen peroxide in heart regeneration (Cell Research)
Achievement: Identified the role of Ptpn23 gene in cardiac diseases (Circulation)

Work Experience

2009-2011 - Peking University - Postdoctoral Researcher
2011-2017 - University of California, San Diego - Postdoctoral/Assistant Project Scientist
2018-Present - Zhejiang University - Researcher

Areas of Focus	Cardiac Development Organ Regeneration Cardiac Diseases
Publications	Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex, Xu C, Zhang G, Wang X, Huang X, Zhang J, Han S, Wang J, Hall DD, Xu R, He F, Chang X, Wang F, Xie W, Wu Z, Song LS, Han P., 2024 Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy, Huang X, Zhang J, Wang W, Huang Z, Han P., 2023 Cardiac cell type-specific responses to injury and contributions to heart regeneration, Zhang W, Liang J, Han P., 2021 Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis, Han P, Bloomekatz J, Ren J, Zhang R, Grinstein J, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC., 2016 Hydrogen peroxide primes heart regeneration with a derepression mechanism, Han P, Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang B, Diao JP, Zhu X, Zhang C, Li CY, Cheng H, Xiong JW., 2014 In vivo cardiac reprogramming contributes to zebrafish heart regeneration, Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC., 2013 Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes, Ren J, Han P, Ma X, Farah EN, Bloomekatz J, Zeng XI, Zhang R, Swim MM, Witty AD, Knight HG, Deshpande R, Xu W, Yelon D, Chen S, Chi NC., 2019 IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model, Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, Zhang W, Li L, Wen Z., 2014 Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos, Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK., 2014 Zebrafish cardiac injury and regeneration models: a noninvasive and invasive in vivo model of cardiac regeneration, Dickover MS, Zhang R, Han P, Chi NC., 2013 Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress, Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim do H., 2013 Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion, Cai WF, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG., 2012 Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression, Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh VP, Chen S, Zhang H, Zhang R, Cheng H, Kranias EG., 2011 Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair, Wang X, Xie W, Zhang Y, Lin P, Han L, Han P, Wang Y, Chen Z, Ji G, Zheng M, Weisleder N, Xiao RP, Takeshima H, Ma J, Cheng H., 2010 Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart, Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H., 2010 The anti-apoptotic protein HAX-1 is a regulator of cardiac function, Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG., 2009 Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice, Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG., 2009 Superoxide flashes in single mitochondria, Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H., 2008

Areas of Focus

Cardiac Development
Organ Regeneration
Cardiac Diseases

Publications

Ptpn23 Controls Cardiac T-Tubule Patterning by Promoting the Assembly of Dystrophin-Glycoprotein Complex, Xu C, Zhang G, Wang X, Huang X, Zhang J, Han S, Wang J, Hall DD, Xu R, He F, Chang X, Wang F, Xie W, Wu Z, Song LS, Han P., 2024
Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy, Huang X, Zhang J, Wang W, Huang Z, Han P., 2023
Cardiac cell type-specific responses to injury and contributions to heart regeneration, Zhang W, Liang J, Han P., 2021
Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis, Han P, Bloomekatz J, Ren J, Zhang R, Grinstein J, Zhao L, Burns CG, Burns CE, Anderson RM, Chi NC., 2016
Hydrogen peroxide primes heart regeneration with a derepression mechanism, Han P, Zhou XH, Chang N, Xiao CL, Yan S, Ren H, Yang XZ, Zhang ML, Wu Q, Tang B, Diao JP, Zhu X, Zhang C, Li CY, Cheng H, Xiong JW., 2014
In vivo cardiac reprogramming contributes to zebrafish heart regeneration, Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY, Yelon D, Chi NC., 2013
Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes, Ren J, Han P, Ma X, Farah EN, Bloomekatz J, Zeng XI, Zhang R, Swim MM, Witty AD, Knight HG, Deshpande R, Xu W, Yelon D, Chen S, Chi NC., 2019
IL-1β and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model, Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, Zhang W, Li L, Wen Z., 2014
Shear stress-activated Wnt-angiopoietin-2 signaling recapitulates vascular repair in zebrafish embryos, Li R, Beebe T, Jen N, Yu F, Takabe W, Harrison M, Cao H, Lee J, Yang H, Han P, Wang K, Shimizu H, Chen J, Lien CL, Chi NC, Hsiai TK., 2014
Zebrafish cardiac injury and regeneration models: a noninvasive and invasive in vivo model of cardiac regeneration, Dickover MS, Zhang R, Han P, Chi NC., 2013
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress, Park CS, Chen S, Lee H, Cha H, Oh JG, Hong S, Han P, Ginsburg KS, Jin S, Park I, Singh VP, Wang HS, Franzini-Armstrong C, Park WJ, Bers DM, Kranias EG, Cho C, Kim do H., 2013
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion, Cai WF, Pritchard T, Florea S, Lam CK, Han P, Zhou X, Yuan Q, Lehnart SE, Allen PD, Kranias EG., 2012
Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression, Han P, Cai W, Wang Y, Lam CK, Arvanitis DA, Singh VP, Chen S, Zhang H, Zhang R, Cheng H, Kranias EG., 2011
Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair, Wang X, Xie W, Zhang Y, Lin P, Han L, Han P, Wang Y, Chen Z, Ji G, Zheng M, Weisleder N, Xiao RP, Takeshima H, Ma J, Cheng H., 2010
Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart, Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H., 2010
The anti-apoptotic protein HAX-1 is a regulator of cardiac function, Zhao W, Waggoner JR, Zhang ZG, Lam CK, Han P, Qian J, Schroder PM, Mitton B, Kontrogianni-Konstantopoulos A, Robia SL, Kranias EG., 2009
Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice, Yuan Q, Han P, Dong M, Ren X, Zhou X, Chen S, Jones WK, Chu G, Wang HS, Kranias EG., 2009
Superoxide flashes in single mitochondria, Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H., 2008

Cardiac Development: Notch Signaling Myocardial Cells Spatial Distribution Ventricular Structure Heart Formation Cardiac Morphogenesis Cardiomyocyte Interactions Heart Regeneration Mapk Signaling Ptpn23 Gene Organ Regeneration: Heart Injury Hydrogen Peroxide Dusp6 Degradation Mapk Pathway Regenerative Medicine Tissue Repair Cellular Regeneration Organ Healing Regenerative Signaling Cardiac Repair Cardiac Diseases: T-Tubule Formation Cardiac Dysfunction Heart Disease Mechanisms Cardiomyopathy Cardiac Pathology Genetic Regulation Heart Failure Cardiac Signaling Myocardial Maintenance

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