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Dante Neculai
Medical School
Zhejiang University
Zhejiang
Language: English, German, Chinese
Lipid Metabolism: Cholesterol
Cd36
Sr-Bi
Limp-2
Lipid Transport
Cell Membrane
Innate Immunity
Molecular Mechanism
Antigen Recognition
Lipid Synthesis
Innate Immunity: Nod1
Nod2
Zdhhc5
Palmitoylation
Pathogen Recognition
Immune Response
Genetic Markers
Inflammatory Bowel Disease
Resistance
Host Defense
Protein Post-Translational Modifications: Hltf
Dna Repair
Hiran Domain
Protein Interaction
Molecular Biology
Cell Replication
Structural Biology
Protein Synthesis
Post-Translational
Protein Regulation
Areas of Focus
- Lipid Metabolism
- Innate Immunity
- Protein Post-Translational Modifications
Work Experience
- Postdoctoral Research - Max Planck Institute for Biophysical Chemistry, Germany
- Postdoctoral Research - Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
- 2009-2014 - Researcher - University of Toronto, Ontario Cancer Institute, and Hospital for Sick Children, Canada
Academic Background & Achievements
- 2003 - PhD in Chemistry: University of Göttingen, Germany
- Discovered channel-like cavity structure in CD36 superfamily proteins (Nature, 2013)
- Identified molecular mechanism of HLTF protein in DNA repair (Nucleic Acids Research, 2015)
- Revealed LIMP-2 and NPC protein interaction (Nat Communs, 2019)
- Discovered palmitoylation modification in NOD1 and NOD2 (Science, 2019)
- Proposed dynamic regulation model for ER-Phagy (EMBO J, 2020)
Publications
- Channel-like cavity structure in CD36 superfamily proteins, Dante Neculai, 2013
- Molecular mechanism of HLTF protein in DNA repair, Dante Neculai, 2015
- LIMP-2 and NPC protein interaction, Dante Neculai, 2019
- Palmitoylation modification in NOD1 and NOD2, Dante Neculai, 2019
- Dynamic regulation model for ER-Phagy, Dante Neculai, 2020
