Professor | Hongshan Guo | Asia Growth Partners

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Name	Hongshan Guo
Language ability	Chinese, English
Province	Zhejiang

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Name

Hongshan Guo

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2007-09 to 2011-07 Bachelor's Degree: Central South University 2011-09 to 2016-07 Doctorate: Peking University (under Prof. Fu-Chou Tang) Developed single-cell DNA methylation and DNA formylation sequencing technology Mapped single-cell DNA methylation landscapes of human early embryos and germ cells Revealed epigenetic regulation abnormalities in breast and prostate cancer metastasis
Work Experience	2017-02 to 2022-01 - Harvard Medical School/Massachusetts General Hospital Cancer Center - Postdoctoral Researcher 2022-02 to 2022-09 - Harvard Medical School/Massachusetts General Hospital Cancer Center - Lecturer 2022-10 to Present - Zhejiang University Liangzhu Laboratory - Researcher, Doctoral Supervisor 2023-01 to Present - Zhejiang University School of Medicine First Affiliated Hospital - Dual-appointed Researcher
Awards	Wu Rui Scholarship: Highest award for Chinese biology doctoral students Peking University May Fourth Medal: Highest honor for Peking University students

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2007-09 to 2011-07 Bachelor's Degree: Central South University
2011-09 to 2016-07 Doctorate: Peking University (under Prof. Fu-Chou Tang)
Developed single-cell DNA methylation and DNA formylation sequencing technology
Mapped single-cell DNA methylation landscapes of human early embryos and germ cells
Revealed epigenetic regulation abnormalities in breast and prostate cancer metastasis

Work Experience

2017-02 to 2022-01 - Harvard Medical School/Massachusetts General Hospital Cancer Center - Postdoctoral Researcher
2022-02 to 2022-09 - Harvard Medical School/Massachusetts General Hospital Cancer Center - Lecturer
2022-10 to Present - Zhejiang University Liangzhu Laboratory - Researcher, Doctoral Supervisor
2023-01 to Present - Zhejiang University School of Medicine First Affiliated Hospital - Dual-appointed Researcher

Awards

Wu Rui Scholarship: Highest award for Chinese biology doctoral students
Peking University May Fourth Medal: Highest honor for Peking University students

Areas of Focus	Single-cell multi-omics sequencing Cancer epigenetics Cancer immune regulation
Publications	DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs, Guo H, Vuille J, Wittner B, Lachtara E, Hou Y, Lin M, Zhao T, Raman A, Russell H, Reeves B, Pleskow H, Wu CL, Gnirke A, Meissner A, Efstathiou J, Lee R, Toner M, Aryee M, Lawrence M, Miyamoto D, Maheswaran S, Haber D., 2023 The DNA methylation landscapes of human early embryos, Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang F, Qiao J., 2014 The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J., 2015 Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing, Guo H, Zhu P, Wu X, Li X, Wen L, Tang F., 2013 Profiling DNA methylome landscapes of mammalian cells with single-cell reduced representation bisulfite sequencing, Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L, Tang F., 2015 DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells, Guo H, Hu B, Yan L, Yong J, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F, Qiao J., 2017 NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer, Guo H, Golczer G, Wittner B, Langenbucher A, Zachariah M, Dubash T, Hong X, Comaills V, Burr R, Ebright R, Horwitz E, Vuille J, Hajizadeh S, Wiley D, Reeves B, Zhang J, Niederhoffer K, Lu C, Wesley B, Ho U, Nieman L, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence M, Haber D., 2021 Single-cell DNA methylome sequencing of human preimplantation embryos, Zhu P, Guo H, Ren Y, Hou Y, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J, Tang F., 2018 Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution, Zhu C, Gao Y, Guo H, Xia B, Song J, Wu X, Zeng H, Kee K, Tang F, Yi C., 2017 Epigenomic landscape of human fetal brain, heart, and liver, Yan L, Guo H, Hu B, Li R, Yong J, Zhao Y, Zhi X, Fan X, Guo F, Wang X, Wang W, Wei Y, Wang Y, Wen L, Qiao J, Tang F., 2016 Intragenic recombination as a mechanism of genetic diversity in bluetongue virus, He C, Ding N, He M, Li S, Wang X, He H, Liu X, Guo H., 2010 Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells, Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R, Qiao J, Tang F., 2013 Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote, Guo F, Li X, Liang D, Li T, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J, Tang F, Xu GL., 2014 H3K4me3 epigenomic landscape derived from ChIP-Seq of 1,000 mouse early embryonic cells, Shen J, Jiang D, Fu Y, Wu X, Guo H, Feng B, Pang Y, Streets AM, Tang F, Huang Y., 2015 Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Wu Y, Zhou H, Fan X, Zhang Y, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L, Tang F, Li J., 2015 Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, Wen L, Li X, Yan L, Tan Y, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J., 2014 Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos, Fan X, Zhang X, Wu X, Guo H, Hu Y, Tang F, Huang Y., 2015 Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions, Li L, Dong J, Yan L, Yong J, Liu X, Hu Y, Fan X, Wu X, Guo H, Wang X, Zhu X, Li R, Yan J, Wei Y, Zhao Y, Wang W, Ren Y, Yuan P, Yan Z, Hu B, Guo F, Wen L, Tang F, Qiao J., 2017 Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing, Gao S, Yan L, Wang R, Li J, Yong J, Zhou X, Wei Y, Wu X, Wang X, Fan X, Yan J, Zhi X, Gao Y, Guo H, Jin X, Wang W, Mao Y, Wang F, Wen L, Fu W, Ge H, Qiao J, Tang F., 2018 Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis, Dong J, Hu Y, Fan X, Wu X, Mao Y, Hu B, Guo H, Wen L, Tang F., 2018 Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution, Zeng H, He B, Xia B, Bai D, Lu X, Cai J, Chen L, Zhou A, Zhu C, Meng H, Gao Y, Guo H, He C, Dai Q, Yi C., 2018 Single-cell multiomics sequencing and analyses of human colorectal cancer, Bian S, Hou Y, Zhou X, Li X, Yong J, Wang Y, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J, Tang F, Fu W., 2018 Cellular prion protein is involved in decidualization of mouse uterus, Ding N, Wang X, Jiao X, Li R, Zeng C, Li S, Guo H, Wang Z, Huang Z, He C., 2018 SETD1A protects from senescence through regulation of the mitotic gene expression program, Tajima K, Matsuda S, Yae T, Drapkin B, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus N, Dyson N, Shioda T, Haas W, Haber D, Maheswaran S., 2019 Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma, Porter R, Magnus N, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni A, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M, Vo K, Nieman L, Liss A, Deshpande V, Lawrence M, Maheswaran S, Fernandez-Del Castillo, Hong T, Ryan D, O'Dwyer P, Drebin J, Ferrone C, Haber D, Ting D., 2019 The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis, Hong X, Roh W*, Sullivan R, Wong K, Wittner B, Guo

Areas of Focus

Single-cell multi-omics sequencing
Cancer epigenetics
Cancer immune regulation

Publications

DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs, Guo H*, Vuille J*, Wittner B, Lachtara E, Hou Y, Lin M, Zhao T, Raman A, Russell H, Reeves B, Pleskow H, Wu CL, Gnirke A, Meissner A, Efstathiou J, Lee R, Toner M, Aryee M, Lawrence M, Miyamoto D, Maheswaran S, Haber D., 2023
The DNA methylation landscapes of human early embryos, Guo H*, Zhu P*, Yan L*, Li R*, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang F, Qiao J., 2014
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Guo F*, Yan L*, Guo H*, Li L*, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J., 2015
Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing, Guo H*, Zhu P*, Wu X, Li X, Wen L, Tang F., 2013
Profiling DNA methylome landscapes of mammalian cells with single-cell reduced representation bisulfite sequencing, Guo H*, Zhu P*, Guo F, Li X, Wu X, Fan X, Wen L, Tang F., 2015
DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells, Guo H*, Hu B*, Yan L*, Yong J*, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F, Qiao J., 2017
NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer, Guo H*, Golczer G*, Wittner B, Langenbucher A, Zachariah M, Dubash T, Hong X, Comaills V, Burr R, Ebright R, Horwitz E, Vuille J, Hajizadeh S, Wiley D, Reeves B, Zhang J, Niederhoffer K, Lu C, Wesley B, Ho U, Nieman L, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence M, Haber D., 2021
Single-cell DNA methylome sequencing of human preimplantation embryos, Zhu P*, Guo H*, Ren Y*, Hou Y*, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J, Tang F., 2018
Single-Cell 5-Formylcytosine Landscapes of Mammalian Early Embryos and ESCs at Single-Base Resolution, Zhu C*, Gao Y*, Guo H*, Xia B*, Song J, Wu X, Zeng H, Kee K, Tang F, Yi C., 2017
Epigenomic landscape of human fetal brain, heart, and liver, Yan L*, Guo H*, Hu B*, Li R*, Yong J, Zhao Y, Zhi X, Fan X, Guo F, Wang X, Wang W, Wei Y, Wang Y, Wen L, Qiao J, Tang F., 2016
Intragenic recombination as a mechanism of genetic diversity in bluetongue virus, He C, Ding N, He M, Li S, Wang X, He H, Liu X, Guo H., 2010
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells, Yan L*, Yang M*, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R, Qiao J, Tang F., 2013
Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote, Guo F*, Li X*, Liang D*, Li T*, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J, Tang F, Xu GL., 2014
H3K4me3 epigenomic landscape derived from ChIP-Seq of 1,000 mouse early embryonic cells, Shen J*, Jiang D*, Fu Y*, Wu X*, Guo H, Feng B, Pang Y, Streets AM, Tang F, Huang Y., 2015
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Wu Y*, Zhou H*, Fan X*, Zhang Y*, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L, Tang F, Li J., 2015
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, Wen L*, Li X*, Yan L*, Tan Y*, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J., 2014
Single-cell RNA-seq transcriptome analysis of linear and circular RNAs in mouse preimplantation embryos, Fan X*, Zhang X*, Wu X, Guo H, Hu Y, Tang F, Huang Y., 2015
Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions, Li L*, Dong J*, Yan L*, Yong J, Liu X, Hu Y, Fan X, Wu X, Guo H, Wang X, Zhu X, Li R, Yan J, Wei Y, Zhao Y, Wang W, Ren Y, Yuan P, Yan Z, Hu B, Guo F, Wen L, Tang F, Qiao J., 2017
Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing, Gao S*, Yan L*, Wang R*, Li J*, Yong J*, Zhou X, Wei Y, Wu X, Wang X, Fan X, Yan J, Zhi X, Gao Y, Guo H, Jin X, Wang W, Mao Y, Wang F, Wen L, Fu W, Ge H, Qiao J, Tang F., 2018
Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis, Dong J*, Hu Y*, Fan X*, Wu X*, Mao Y, Hu B, Guo H, Wen L, Tang F., 2018
Bisulfite-Free, Nanoscale Analysis of 5-Hydroxymethylcytosine at Single Base Resolution, Zeng H*, He B*, Xia B, Bai D, Lu X, Cai J, Chen L, Zhou A, Zhu C, Meng H, Gao Y, Guo H, He C, Dai Q, Yi C., 2018
Single-cell multiomics sequencing and analyses of human colorectal cancer, Bian S*, Hou Y*, Zhou X*, Li X*, Yong J*, Wang Y*, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J, Tang F, Fu W., 2018
Cellular prion protein is involved in decidualization of mouse uterus, Ding N, Wang X, Jiao X, Li R, Zeng C, Li S, Guo H, Wang Z, Huang Z, He C., 2018
SETD1A protects from senescence through regulation of the mitotic gene expression program, Tajima K*, Matsuda S*, Yae T*, Drapkin B, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus N, Dyson N, Shioda T, Haas W, Haber D, Maheswaran S., 2019
Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma, Porter R, Magnus N, Thapar V, Morris R, Szabolcs A, Neyaz A, Kulkarni A, Tai E, Chougule A, Hillis A, Golczer G, Guo H, Yamada T, Kurokawa T, Yashaswini C, Ligorio M, Vo K, Nieman L, Liss A, Deshpande V, Lawrence M, Maheswaran S, Fernandez-Del Castillo, Hong T, Ryan D, O'Dwyer P, Drebin J, Ferrone C, Haber D, Ting D., 2019
The lipogenic regulator SREBF2 induces Transferrin in circulating melanoma cells and suppresses ferroptosis, Hong X*, Roh W*, Sullivan R, Wong K, Wittner B, Guo

Single-Cell Sequencing Multi-Omics Dna Methylation Dna Formylation Epigenetics Cancer Immune Regulation Breast Cancer Prostate Cancer Metastasis

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Li-Rong Chen - Zhejiang University

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