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Zhang Pumin
Medical School
Zhejiang University
Zhejiang
Language: English, Chinese
Cell Cycle
P21
P57
Beckwith-Wiedemann Syndrome
Aneuploidy Checkpoint
Tumorigenesis
Homologous Recombination
Crispr
Genetic Screening
Tumor Therapeutic Targets
Areas of Focus
- Cell Cycle
- Tumor Cell Biology and Tumor Genomic Instability Mechanisms
- Discovery of Novel Tumor Therapeutic Targets
Work Experience
- 1993.09-1998.10 - Baylor College of Medicine - Postdoctoral Researcher
- 1998.11-2000.11 - National Jewish Medical and Research Center, University of Colorado - Assistant Professor
- 2000.12-2019.12 - Baylor College of Medicine - Assistant Professor/Associate Professor/Professor
- 2011.11-2020.03 - Beijing Proteome Research Center - Researcher/Deputy Director
- 2020.04-Present - Zhejiang University School of Medicine, First Affiliated Hospital - Professor
Academic Background & Achievements
- 1980.09-1984.07 Bachelor in Pharmacy: Shanghai Medical University
- 1984.09-1987.07 Master in Biochemistry: Shanghai Medical University
- 1989.09-1993.08 PhD in Biochemistry: University of Wisconsin-Madison
- Achievement: Clarified the role of p21 in cell cycle and embryonic development
- Achievement: Proved p57 as the pathogenic gene of Beckwith-Wiedemann syndrome
- Achievement: Discovered aneuploidy checkpoint and its role in tumorigenesis
- Achievement: Developed homologous recombination cloning technology and CRISPR technology
- Achievement: Conducted genetic screening in mammalian embryos for the first time
- Achievement: Developed novel tumor therapeutic targets and constructed a potential drug target sgRNA library
