Professor | Dongwu Lai | Asia Growth Partners

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Name	Dongwu Lai
Contact Information	laidw@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Dongwu Lai

Contact Information

laidw@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	Visiting Scholar: Emory University, USA Selected as a high-level young talent in the province Reserve leader of the multidisciplinary innovation team of traditional Chinese medicine in the province

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

Visiting Scholar: Emory University, USA
Selected as a high-level young talent in the province
Reserve leader of the multidisciplinary innovation team of traditional Chinese medicine in the province

Areas of Focus	Molecular mechanisms of pathological cardiac remodeling and organelle dynamic networks Key regulatory proteins and post-translational modification mechanisms of cardiac remodeling
Publications	Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle, Xue Lu, Yingchao Gong, Wanyu Hu, Yankai Mao, Ting Wang, Zeyu Sun, Xiaoling Su, Guosheng Fu, Yanpeng Wang, Dongwu Lai, 2022 Structural basis for the gating modulation of Kv4.3 by auxiliary subunits, Demin Ma, Cheng Zhao, Xiaochen Wang, Xiaoxiao Li, Yi Zha, Yan Zhang, Guosheng Fu, Ping Liang, Jiangtao Guo, Dongwu Lai, 2022 Appraising the Causal Association between Systemic Iron Status and Heart Failure Risk: A Mendelian Randomisation Study, Wang X, Wang X, Gong Y, Chen X, Zhong D, Zhu J, Zhuang L, Gao J, Fu G, Lu X, Lai D, 2022 The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling, Lai D, Gao J, Bi X, He H, Shi X, Weng S, Chen Y, Yang Y, Ye Y, Fu G, 2017 Stretch current-induced abnormal impulses in CaMKIIδ knockout mouse ventricular myocytes, Lai D, Xu L, Cheng J, Guilbert AB, Lim HJ, Fu G, Wang Y, 2013 Alterations of L-Type Calcium Current and Cardiac Function in CaMKII Knockout Mice, Lin Xu, Dongwu Lai, Jun Cheng, Hyun Joung Lim, Thitima Keskanokwong, Johannes Backs, Eric N. Olson, Yanggan Wang, 2010 Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas, Fu J, Zhu Q, Chen Z, Zhao J, Wu S, Zhao M, Xu S, Lai D, Fu G, Zhang W, 2023 FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis, Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L, 2022 Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis, Ma Z, Wang X, Lv Q, Gong Y, Xia M, Zhuang L, Lu X, Yang Y, Zhang W, Fu G, Ye Y, Lai D, 2021 Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes, Gao Jing, Shi X, He H, Zhang J, Lin D, Fu G, Lai D, 2017 Inhibition of the mevalonate pathway ameliorates anoxia–induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells, Yang Y, Lv X, Rong XQ, Jiang WB, Lai DW, Ma Y, Zhou K, Fu GS, Xu SM, 2015 CaMKII inhibition in heart failure, beneficial, harmful, or both, Jun Cheng, Lin Xu, Dongwu Lai, Arnaud Guilbert, Hyun Joung Lim, Thitima Keskanokwong, Yanggan Wang, 2012 ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells, Hu P, Lai D, Lu P, Gao J, He H, 2012 Dynamic Kv4.3-CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation, Keskanokwong T, Lim HJ, Zhang P, Cheng J, Xu L, Lai D, Wang Y, 2011

Areas of Focus

Molecular mechanisms of pathological cardiac remodeling and organelle dynamic networks
Key regulatory proteins and post-translational modification mechanisms of cardiac remodeling

Publications

Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle, Xue Lu, Yingchao Gong, Wanyu Hu, Yankai Mao, Ting Wang, Zeyu Sun, Xiaoling Su, Guosheng Fu, Yanpeng Wang, Dongwu Lai, 2022
Structural basis for the gating modulation of Kv4.3 by auxiliary subunits, Demin Ma, Cheng Zhao, Xiaochen Wang, Xiaoxiao Li, Yi Zha, Yan Zhang, Guosheng Fu, Ping Liang, Jiangtao Guo, Dongwu Lai, 2022
Appraising the Causal Association between Systemic Iron Status and Heart Failure Risk: A Mendelian Randomisation Study, Wang X, Wang X, Gong Y, Chen X, Zhong D, Zhu J, Zhuang L, Gao J, Fu G, Lu X, Lai D, 2022
The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling, Lai D, Gao J, Bi X, He H, Shi X, Weng S, Chen Y, Yang Y, Ye Y, Fu G, 2017
Stretch current-induced abnormal impulses in CaMKIIδ knockout mouse ventricular myocytes, Lai D, Xu L, Cheng J, Guilbert AB, Lim HJ, Fu G, Wang Y, 2013
Alterations of L-Type Calcium Current and Cardiac Function in CaMKII Knockout Mice, Lin Xu, Dongwu Lai, Jun Cheng, Hyun Joung Lim, Thitima Keskanokwong, Johannes Backs, Eric N. Olson, Yanggan Wang, 2010
Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas, Fu J, Zhu Q, Chen Z, Zhao J, Wu S, Zhao M, Xu S, Lai D, Fu G, Zhang W, 2023
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis, Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L, 2022
Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis, Ma Z, Wang X, Lv Q, Gong Y, Xia M, Zhuang L, Lu X, Yang Y, Zhang W, Fu G, Ye Y, Lai D, 2021
Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes, Gao Jing, Shi X, He H, Zhang J, Lin D, Fu G, Lai D, 2017
Inhibition of the mevalonate pathway ameliorates anoxia–induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells, Yang Y, Lv X, Rong XQ, Jiang WB, Lai DW, Ma Y, Zhou K, Fu GS, Xu SM, 2015
CaMKII inhibition in heart failure, beneficial, harmful, or both, Jun Cheng, Lin Xu, Dongwu Lai, Arnaud Guilbert, Hyun Joung Lim, Thitima Keskanokwong, Yanggan Wang, 2012
ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells, Hu P, Lai D, Lu P, Gao J, He H, 2012
Dynamic Kv4.3-CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation, Keskanokwong T, Lim HJ, Zhang P, Cheng J, Xu L, Lai D, Wang Y, 2011

Cardiac Remodeling Organelle Dynamics Molecular Mechanisms Regulatory Proteins Post-Translational Modifications Cardiovascular Diseases Cellular Homeostasis Mitochondria Endoplasmic Reticulum Heart Failure

Jian Yang - Zhejiang University

Meixiang Xiang - Zhejiang University

Cong Yi - Zhejiang University

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