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Dongwu Lai
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Cardiac Remodeling
Organelle Dynamics
Molecular Mechanisms
Regulatory Proteins
Post-Translational Modifications
Cardiovascular Diseases
Cellular Homeostasis
Mitochondria
Endoplasmic Reticulum
Heart Failure
Areas of Focus
- Molecular mechanisms of pathological cardiac remodeling and organelle dynamic networks
- Key regulatory proteins and post-translational modification mechanisms of cardiac remodeling
Academic Background & Achievements
- Visiting Scholar: Emory University, USA
- Selected as a high-level young talent in the province
- Reserve leader of the multidisciplinary innovation team of traditional Chinese medicine in the province
Publications
- Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle, Xue Lu, Yingchao Gong, Wanyu Hu, Yankai Mao, Ting Wang, Zeyu Sun, Xiaoling Su, Guosheng Fu, Yanpeng Wang, Dongwu Lai, 2022
- Structural basis for the gating modulation of Kv4.3 by auxiliary subunits, Demin Ma, Cheng Zhao, Xiaochen Wang, Xiaoxiao Li, Yi Zha, Yan Zhang, Guosheng Fu, Ping Liang, Jiangtao Guo, Dongwu Lai, 2022
- Appraising the Causal Association between Systemic Iron Status and Heart Failure Risk: A Mendelian Randomisation Study, Wang X, Wang X, Gong Y, Chen X, Zhong D, Zhu J, Zhuang L, Gao J, Fu G, Lu X, Lai D, 2022
- The Rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling, Lai D, Gao J, Bi X, He H, Shi X, Weng S, Chen Y, Yang Y, Ye Y, Fu G, 2017
- Stretch current-induced abnormal impulses in CaMKIIδ knockout mouse ventricular myocytes, Lai D, Xu L, Cheng J, Guilbert AB, Lim HJ, Fu G, Wang Y, 2013
- Alterations of L-Type Calcium Current and Cardiac Function in CaMKII Knockout Mice, Lin Xu, Dongwu Lai, Jun Cheng, Hyun Joung Lim, Thitima Keskanokwong, Johannes Backs, Eric N. Olson, Yanggan Wang, 2010
- Polydopamine (PDA) coatings with endothelial vascular growth factor (VEGF) immobilization inhibiting neointimal formation post zinc (zn) wire implantation in rat aortas, Fu J, Zhu Q, Chen Z, Zhao J, Wu S, Zhao M, Xu S, Lai D, Fu G, Zhang W, 2023
- FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis, Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L, 2022
- Identification of Underlying Hub Genes Associated with Hypertrophic Cardiomyopathy by Integrated Bioinformatics Analysis, Ma Z, Wang X, Lv Q, Gong Y, Xia M, Zhuang L, Lu X, Yang Y, Zhang W, Fu G, Ye Y, Lai D, 2021
- Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes, Gao Jing, Shi X, He H, Zhang J, Lin D, Fu G, Lai D, 2017
- Inhibition of the mevalonate pathway ameliorates anoxia–induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells, Yang Y, Lv X, Rong XQ, Jiang WB, Lai DW, Ma Y, Zhou K, Fu GS, Xu SM, 2015
- CaMKII inhibition in heart failure, beneficial, harmful, or both, Jun Cheng, Lin Xu, Dongwu Lai, Arnaud Guilbert, Hyun Joung Lim, Thitima Keskanokwong, Yanggan Wang, 2012
- ERK and Akt signaling pathways are involved in advanced glycation end product-induced autophagy in rat vascular smooth muscle cells, Hu P, Lai D, Lu P, Gao J, He H, 2012
- Dynamic Kv4.3-CaMKII unit in heart: an intrinsic negative regulator for CaMKII activation, Keskanokwong T, Lim HJ, Zhang P, Cheng J, Xu L, Lai D, Wang Y, 2011
