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Hou Yu
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Single-Cell Sequencing
Multi-Omics
Tumor
Immunity
Gene Screening
Autoimmune
Diseases
Genomics
Transcriptomics
Epigenetics
Areas of Focus
- Single-cell multi-omics sequencing
- Tumor immunity
- Gene function screening
- Autoimmune diseases
Work Experience
- 2008-09 to 2012-07: China Agricultural University - Bachelor Student
- 2012-09 to 2017-07: Peking University - Ph.D. Student
- 2018-02 to 2022-10: Harvard Medical School/Brigham and Women's Hospital - Postdoctoral Researcher
- 2022-11 to present: Zhejiang University Medical Center/Liangzhu Laboratory - Researcher and Doctoral Supervisor
Academic Background & Achievements
- 2008-09 to 2012-07: Bachelor's degree in Science from China Agricultural University
- 2012-09 to 2017-07: Ph.D. in Life Sciences from Peking University (under Prof. Tang Fuchou)
- 2018-02 to 2022-10: Postdoctoral research at Harvard Medical School/Brigham and Women's Hospital (under Prof. Vijay K. Kuchroo)
- 2022-11 to present: Researcher and Doctoral Supervisor at Zhejiang University Medical Center/Liangzhu Laboratory
Publications
- Genome analyses of single human oocytes, Hou Y*, Fan W*, Yan LY*, Li R, Lian Y, Huang J, Li J, Xu L, Tang F, Xie X, Qiao J., 2013
- Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas, Hou Y*, Guo H*, Cao C, Li X, Hu B, Zhu P, Wu X, Wen L, Tang F, Huang Y, Peng J., 2016
- Single-cell multiomics sequencing and analyses of human colorectal cancer, Bian S*, Hou Y*, Zhou X*, Li X*, Yong J*, Wang Y*, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J, Tang F, Fu W., 2018
- Single-cell DNA methylome sequencing of human preimplantation embryos, Zhu P*, Guo H*, Ren Y*, Hou Y*, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J, Tang F., 2018
- Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages, Yang X*, Hu B*, Hou Y*, Qiao Y*, Wang R, Chen Y, Qian Y, Feng S, Chen J, Liu C, Peng G, Tang F, Jing N., 2018
- Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, Wen L*, Li X*, Yan L*, Tan Y*, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J., 2014
- The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Guo F*, Yan L*, Guo H*, Li L*, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J., 2015
- LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration, Shi Y*, Wu W*, Chai Q*, Li Q, Hou Y, Xia H, Ren B, Xu H, Guo X, Jin C, Lv M, Wang Z, Fu UX, Zhu M., 2016
- Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish, Xiao C*, Gao L*, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo Y, Wang J, Peng J, Tang F, Zhu X, Xiong J., 2016
- DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells, Guo H*, Hu B*, Yan L*, Yong J*, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F, Qiao J., 2017
- Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells, Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima Mm, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K,m Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L., 2018
- Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis, Wang M*, Liu X*, Chang G*, Chen Y*, An G*, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F, Zhao X, Qiao J., 2018
- Single-cell RNA-seq analysis reveals the progression of human osteoarthritis, Ji Q*, Zheng Y*, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y, Tang F., 2019
- Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development, Yang X*, Hu B*, Liao J*, Qiao Y*, Chen Y, Qian Y, Feng S, Yu F, Dong J, Hou Y, Xu H, Wang R, Peng G, Li J, Tang F, Jing N., 2019
- Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses, Hou S*, Li Z*, Zheng X*, Gao Y*, Dong J*, Ni Y*, Wang X, Li Y, Ding X, Chang Z, Li S, Hu Y, Fan X, Hou Y, Wen L, Liu B, Tang F, Lan Y., 2020
- Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function, He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christin E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK., 2022
- Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals, Hou S*, Li Z*, Dong J*, Gao Y*, Chang Z*, Ding X*, Li S, Li Y, Zeng Y, Xin Q, Wang B, Ni Y, Ning X, Hu Y, Fang X, Hou Y, Li X, Wen L, Zhou B, Liu B, Tang F, Lan Y., 2022
- Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function, Tang R, Acharya N, Subramanian A, Purohit V, Tabaka M, Hou Y, He D, Dixon KO, Lambden C, Xia J, Rozenblatt-Rosen O, Sobel RA, Wang C, Regev A, Anderson AC, Kuchroo VK., 2022
