2008-09 to 2012-07: Bachelor's degree in Science from China Agricultural University
2012-09 to 2017-07: Ph.D. in Life Sciences from Peking University (under Prof. Tang Fuchou)
2018-02 to 2022-10: Postdoctoral research at Harvard Medical School/Brigham and Women's Hospital (under Prof. Vijay K. Kuchroo)
2022-11 to present: Researcher and Doctoral Supervisor at Zhejiang University Medical Center/Liangzhu Laboratory
2008-09 to 2012-07: China Agricultural University - Bachelor Student
2012-09 to 2017-07: Peking University - Ph.D. Student
2018-02 to 2022-10: Harvard Medical School/Brigham and Women's Hospital - Postdoctoral Researcher
2022-11 to present: Zhejiang University Medical Center/Liangzhu Laboratory - Researcher and Doctoral Supervisor
Research
Single-cell multi-omics sequencing Tumor immunity Gene function screening Autoimmune diseases
Genome analyses of single human oocytes, Hou Y*, Fan W*, Yan LY*, Li R, Lian Y, Huang J, Li J, Xu L, Tang F, Xie X, Qiao J., 2013
Single-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas, Hou Y*, Guo H*, Cao C, Li X, Hu B, Zhu P, Wu X, Wen L, Tang F, Huang Y, Peng J., 2016
Single-cell multiomics sequencing and analyses of human colorectal cancer, Bian S*, Hou Y*, Zhou X*, Li X*, Yong J*, Wang Y*, Wang W, Yan J, Hu B, Guo H, Wang J, Gao S, Mao Y, Dong J, Zhu P, Xiu D, Yan L, Wen L, Qiao J, Tang F, Fu W., 2018
Single-cell DNA methylome sequencing of human preimplantation embryos, Zhu P*, Guo H*, Ren Y*, Hou Y*, Dong J, Li R, Lian Y, Fan X, Hu B, Gao Y, Wang X, Wei Y, Liu P, Yan J, Ren X, Yuan P, Yuan Y, Yan Z, Wen L, Yan L, Qiao J, Tang F., 2018
Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages, Yang X*, Hu B*, Hou Y*, Qiao Y*, Wang R, Chen Y, Qian Y, Feng S, Chen J, Liu C, Peng G, Tang F, Jing N., 2018
Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain, Wen L*, Li X*, Yan L*, Tan Y*, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C, Li R, Tang F, Qiao J., 2014
The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells, Guo F*, Yan L*, Guo H*, Li L*, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F, Qiao J., 2015
LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration, Shi Y*, Wu W*, Chai Q*, Li Q, Hou Y, Xia H, Ren B, Xu H, Guo X, Jin C, Lv M, Wang Z, Fu UX, Zhu M., 2016
Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish, Xiao C*, Gao L*, Hou Y, Xu C, Chang N, Wang F, Hu K, He A, Luo Y, Wang J, Peng J, Tang F, Zhu X, Xiong J., 2016
DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells, Guo H*, Hu B*, Yan L*, Yong J*, Wu Y, Gao Y, Guo F, Hou Y, Fan X, Dong J, Wang X, Zhu X, Yan J, Wei Y, Jin H, Zhang W, Wen L, Tang F, Qiao J., 2017
Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells, Yu L, Li J, Hong J, Takashima Y, Fujimoto N, Nakajima Mm, Yamamoto A, Dong X, Dang Y, Hou Y, Yang W, Minami I, Okita K,m Tanaka M, Luo C, Tang F, Chen Y, Tang C, Kotera H, Liu L., 2018
Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis, Wang M*, Liu X*, Chang G*, Chen Y*, An G*, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F, Zhao X, Qiao J., 2018
Single-cell RNA-seq analysis reveals the progression of human osteoarthritis, Ji Q*, Zheng Y*, Zhang G, Hu Y, Fan X, Hou Y, Wen L, Li L, Xu Y, Wang Y, Tang F., 2019
Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development, Yang X*, Hu B*, Liao J*, Qiao Y*, Chen Y, Qian Y, Feng S, Yu F, Dong J, Hou Y, Xu H, Wang R, Peng G, Li J, Tang F, Jing N., 2019
Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses, Hou S*, Li Z*, Zheng X*, Gao Y*, Dong J*, Ni Y*, Wang X, Li Y, Ding X, Chang Z, Li S, Hu Y, Fan X, Hou Y, Wen L, Liu B, Tang F, Lan Y., 2020
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function, He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christin E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK., 2022
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals, Hou S*, Li Z*, Dong J*, Gao Y*, Chang Z*, Ding X*, Li S, Li Y, Zeng Y, Xin Q, Wang B, Ni Y, Ning X, Hu Y, Fang X, Hou Y, Li X, Wen L, Zhou B, Liu B, Tang F, Lan Y., 2022
Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function, Tang R, Acharya N, Subramanian A, Purohit V, Tabaka M, Hou Y, He D, Dixon KO, Lambden C, Xia J, Rozenblatt-Rosen O, Sobel RA, Wang C, Regev A, Anderson AC, Kuchroo VK., 2022
