Professor | Shengyong Yin | Asia Growth Partners

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Name	Shengyong Yin
Contact Information	yinsy@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Shengyong Yin

Contact Information

yinsy@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	1995-2003 PhD in Biophysics: Zhejiang University 1991-1995 Bachelor's in Biology: Zhejiang University
Work Experience	2008-present - Zhejiang University First Affiliated Hospital - Associate Researcher 2007-2008 - Texas Tech University Health Sciences Center - Postdoctoral Researcher in Cell Physiology 2004-2007 - Zhejiang University First Affiliated Hospital - Assistant Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

1995-2003 PhD in Biophysics: Zhejiang University
1991-1995 Bachelor's in Biology: Zhejiang University

Work Experience

2008-present - Zhejiang University First Affiliated Hospital - Associate Researcher
2007-2008 - Texas Tech University Health Sciences Center - Postdoctoral Researcher in Cell Physiology
2004-2007 - Zhejiang University First Affiliated Hospital - Assistant Researcher

Areas of Focus	Nanosecond Pulsed Electric Field Tumor Ablation Tumor Physical Therapy Biophysics Irreversible Electroporation
Publications	Ultrastructural changes in hepatocellular carcinoma cells induced by exponential pulses of nanosecond duration delivered via a transmission line, Yin, S.#, Liu, Z.#, Mashayekh, A. S., Guo, D., Qian, J., Wang, Y., Deng, G., Zheng, C., Ma, Z., Zhou, L., Yan, K. & Zheng, S., 2020 Blocking exposed PD-L1 elicited by nanosecond pulsed electric field reverses dysfunction of CD8(+) T cells in liver cancer, Qian, J., Chen, T., Wu, Q., Zhou, L., Zhou, W., Wu, L., Wang, S., Lu, J., Wang, W., Li, D., Xie, H., Su, R., Guo, D., Liu, Z., He, N., Yin, S.* & Zheng, S., 2020 Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer, Wu, Q.#, Zhou, W.#, Yin, S.#, Zhou, Y., Chen, T., Qian, J., Su, R., Hong, L., Lu, H., Zhang, F., Xie, H., Zhou, L. & Zheng, S., 2019 Variations of the Ca2+ Concentrations In Calcium Pools of Hypo-temperature-preserved Cat Kidney Cortex Cells, Yin, SY; Ge, JG and Lin, ZF, 2000 Design of Digital Flowmeter Based on Intel 8051 Singlechip, Lin, ZF; Ge, JG and Yin, SY, 2001 X-ray Microanalysis Detect Subcellular Calcium in Isolated Preserved Kidney, Yin, SY; Ge, JG and Guo M, 2002 Changes of Subcellular Calcium in Hypo-Themal-Preserved Cat Kidney Cortex Cells that Detected by X-ray Microanalysis of Microsections, Yin, SY; Ge, JG and Lin, ZF, 2002 Researches on dynamic process of physiological function change, and its internal structure transform of off-body perfusing kidney, Yin, SY; Ge, JG and Guo, M, 2004 An artificial life-maintainable system for the off-body kidney under low-temperature perfusion in the cat, Xu, QP; Chen, ZW and Yin, SY, 2005 Dynamic profiles of calcium in epithelia of cold-preservation off-body kidney, Guo, M; Ge, JG and Yin, SY, 2005 Co-expression of receptor tyrosine kinase c-kit and its ligand SCF in normal liver and hepatocellular carcinoma tissue, Yin, SY; Hu, C; Li, JJ; Ge, C; Zheng, SS and Gu, JR, 2006 ATP-binding cassette families and the multi-drug resistance of Cancer stem cell, Hu, C; Yin, SY and Li, JJ, 2006 Researches on intrinsic mechanism of renal function during long term perfused kidney, Yin, SY; Ge, JG and Guo, M, 2006 CD133 Positive Hepatocellular Carcinoma Cells Possess High Capacity for Tumorigenicity, Yin, SY; Li , JJ; Hu, C; Chen, XH; Yao, M; Yan, MX; Jiang, GP; Ge, C; Xie, HY; Wan, DF; Yang, SL; Zheng, SS and Gu, JR, 2007 Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma, Bai X, Wu L, Liang T, Liu Z, Li J, Li D, Xie H, Yin S, Yu J, Lin Q, Zheng S, 2008 MMP2 promoter polymorphism (C-1306T) and risk of recurrence in patients with hepatocellular carcinoma after transplantation, Wu LM, Zhang F, Xie HY, Xu X, Chen QX, Yin SY, Liu XC, Zhou L, Xu XB, Sun YL, Zheng SS, 2008 The stem-like cells in HBV-associated cirrhotic liver and adjacent tissue to HCC possess the capacity of tumorigenicity, Sun Y, Yin S, Wu L, Zhou L, Xie H, Zheng S, 2008 Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling, Hu C, Li H, Li J, Zhu Z, Yin S, Hao X, Yao M, Zheng S, Gu J, 2008 Modulation of Cx46 hemichannels by nitric oxide, Retamal M. A, Yin S, Altenberg G. A, Reuss L, 2009 Voltage-dependent facilitation of Cx46 hemichannels, Retamal M.A, Yin S, Altenberg G.A, Reuss L, 2010 Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population, Wu LM, Chen L, Zhou L, Xie HY, Wei BJ, Yin SY, Ye YF, Fang WJ, Zheng SS, 2011 Hepatocyte differentiation of human fibroblasts from cirrhotic liver in vitro and in vivo, Sun YL, Yin SY, Zhou L, Xie HY, Zhang F, Wu LM, Zheng SS, 2011 Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF), Chen X, Chen X, Swanson RJ, Schoenbach KH, Yin S, Zheng S, 2011 Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis, Chen X, Zhang J, Feng X, Chen X, Yin S, Wen H, Zheng S, 2013 Hypoxia preconditioned bone marrow mesenchymal stem cells promote liver regeneration in a rat massive hepatectomy model, Yu J, Yin S, Zhang W, Gao F, Liu Y, Chen Z, Zhang M, He J, Zheng S, 2013 Nanosecond pulsed electric field inhibits cancer growth followed by alteration in expressions of NF-kappaB and Wnt/beta-catenin signaling molecules, Ren Z, Chen X, Cui G, Yin S, Chen L, Jiang J, Hu Z, Xie H, Zheng S, Zhou L, 2013 Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing, Wang H，Chen W，Xie H，Wei X，Yin S，Zhou L，Xu X，Zheng S, 2014 Comparative study of nanosecond electric fields in vitro and in vivo on hepatocellular carcinoma indicate macrophage infiltration contribute to tumor ablation in vivo, Chen X, Yin S, Hu C, Chen X, Jiang K, Ye S, Feng X, Fan S, Xie H, Zhou L, Zheng S, 2014 Nanosecond pulsed electric field (nsPEF) treatment for hepatocellular carcinoma: A novel locoregional ablation decreasing lung metastasis, Yin S, Chen X, Hu C, Zhang X, Hu Z, Yu J, Feng X, Jiang K, Ye S, Shen K, Xie H, Zhou L, James Swanson R, Zheng S, 2014 Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma, Xie H，Xing C，Wei B，Xu X，Wu J，Chen L，Cao G，Chen H，Chen K，Yin S，Wu L，Zhou L，Zheng S, 2014 Association of RNF43 with cell cycle proteins involved in p53 pathway, Xie H，Xing C，Cao G，Wei B，Xu X，Song P，Chen L，Chen H，Yin S，Zhou L，Zheng S, 2015 Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma, Xie H，Xing C，Wei B，Xu X，Wu L，Wu J，Chen L，Cao G，Chen H，Meng X，Yin S，Zhou L，Zheng S, 2015 Nanosecond pulsed electric field inhibits proliferation and induces apoptosis in human osteosarcoma, Miao X，Yin S，Shao Z，Zhang Y，Chen X, 2015 Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells, Cheng J，Li W，Kang B，Zhou Y，Song J，Dan S，Yang Y，Zhang X，Li J，Yin S，Cao H，Yao H，Zhu C，Yi W，Zhao Q，Xu X，Zheng M，Zheng S，Li L，Shen B，Wang Y, 2015 Akt-mediated phosphorylation of Oct4 is associated with the proliferation of stem-like cancer cells, Zhao Q，Zhou Y，Li W，Kang B，Zhang X，Yang Y，Cheng J，Yin S，Tong Y，He J，Yao H，Zheng M，Wang Y, 2015 Porta hepatic schwannoma: case report and a 30-year review of the literature yielding 15 cases, Yin S，Zhai, Z，Ren K，Yang Y，Wan D，Liu X，Wang L，Zheng S, 2016 Solanine-induced reactive oxygen species inhibit the growth of human hepatocellular carcinoma HepG2 cells, Meng Xu，Zhang W，Zhang F，Yin S，Xie H，Zhou L，Zheng S, 2016 Cytokine and human leukocyte antigen (HLA) profile for graft-versus-host disease (GVHD) after organ transplantation

Areas of Focus

Nanosecond Pulsed Electric Field Tumor Ablation
Tumor Physical Therapy
Biophysics
Irreversible Electroporation

Publications

Ultrastructural changes in hepatocellular carcinoma cells induced by exponential pulses of nanosecond duration delivered via a transmission line, Yin, S.#*, Liu, Z.#, Mashayekh, A. S., Guo, D., Qian, J., Wang, Y., Deng, G., Zheng, C., Ma, Z., Zhou, L., Yan, K. & Zheng, S.*, 2020
Blocking exposed PD-L1 elicited by nanosecond pulsed electric field reverses dysfunction of CD8(+) T cells in liver cancer, Qian, J., Chen, T., Wu, Q., Zhou, L., Zhou, W., Wu, L., Wang, S., Lu, J., Wang, W., Li, D., Xie, H., Su, R., Guo, D., Liu, Z., He, N., Yin, S.* & Zheng, S.*, 2020
Blocking Triggering Receptor Expressed on Myeloid Cells-1-Positive Tumor-Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti-Programmed Cell Death Ligand 1 Resistance in Liver Cancer, Wu, Q.#, Zhou, W.#, Yin, S.#, Zhou, Y., Chen, T., Qian, J., Su, R., Hong, L., Lu, H., Zhang, F., Xie, H., Zhou, L. & Zheng, S.*, 2019
Variations of the Ca2+ Concentrations In Calcium Pools of Hypo-temperature-preserved Cat Kidney Cortex Cells, Yin, SY; Ge, JG and Lin, ZF, 2000
Design of Digital Flowmeter Based on Intel 8051 Singlechip, Lin, ZF; Ge, JG and Yin, SY, 2001
X-ray Microanalysis Detect Subcellular Calcium in Isolated Preserved Kidney, Yin, SY; Ge, JG and Guo M, 2002
Changes of Subcellular Calcium in Hypo-Themal-Preserved Cat Kidney Cortex Cells that Detected by X-ray Microanalysis of Microsections, Yin, SY; Ge, JG and Lin, ZF, 2002
Researches on dynamic process of physiological function change, and its internal structure transform of off-body perfusing kidney, Yin, SY; Ge, JG and Guo, M, 2004
An artificial life-maintainable system for the off-body kidney under low-temperature perfusion in the cat, Xu, QP; Chen, ZW and Yin, SY, 2005
Dynamic profiles of calcium in epithelia of cold-preservation off-body kidney, Guo, M; Ge, JG and Yin, SY, 2005
Co-expression of receptor tyrosine kinase c-kit and its ligand SCF in normal liver and hepatocellular carcinoma tissue, Yin, SY; Hu, C; Li, JJ; Ge, C; Zheng, SS and Gu, JR, 2006
ATP-binding cassette families and the multi-drug resistance of Cancer stem cell, Hu, C; Yin, SY and Li, JJ, 2006
Researches on intrinsic mechanism of renal function during long term perfused kidney, Yin, SY; Ge, JG and Guo, M, 2006
CD133 Positive Hepatocellular Carcinoma Cells Possess High Capacity for Tumorigenicity, Yin, SY; Li , JJ; Hu, C; Chen, XH; Yao, M; Yan, MX; Jiang, GP; Ge, C; Xie, HY; Wan, DF; Yang, SL; Zheng, SS and Gu, JR, 2007
Overexpression of myocyte enhancer factor 2 and histone hyperacetylation in hepatocellular carcinoma, Bai X, Wu L, Liang T, Liu Z, Li J, Li D, Xie H, Yin S, Yu J, Lin Q, Zheng S, 2008
MMP2 promoter polymorphism (C-1306T) and risk of recurrence in patients with hepatocellular carcinoma after transplantation, Wu LM, Zhang F, Xie HY, Xu X, Chen QX, Yin SY, Liu XC, Zhou L, Xu XB, Sun YL, Zheng SS, 2008
The stem-like cells in HBV-associated cirrhotic liver and adjacent tissue to HCC possess the capacity of tumorigenicity, Sun Y, Yin S, Wu L, Zhou L, Xie H, Zheng S, 2008
Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling, Hu C, Li H, Li J, Zhu Z, Yin S, Hao X, Yao M, Zheng S, Gu J, 2008
Modulation of Cx46 hemichannels by nitric oxide, Retamal M. A, Yin S, Altenberg G. A, Reuss L, 2009
Voltage-dependent facilitation of Cx46 hemichannels, Retamal M.A, Yin S, Altenberg G.A, Reuss L, 2010
Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population, Wu LM, Chen L, Zhou L, Xie HY, Wei BJ, Yin SY, Ye YF, Fang WJ, Zheng SS, 2011
Hepatocyte differentiation of human fibroblasts from cirrhotic liver in vitro and in vivo, Sun YL, Yin SY, Zhou L, Xie HY, Zhang F, Wu LM, Zheng SS, 2011
Histopathological follow-up by tissue micro-array in a survival study after melanoma treated by nanosecond pulsed electric fields (nsPEF), Chen X, Chen X, Swanson RJ, Schoenbach KH, Yin S, Zheng S, 2011
Humoral Immune Response and Pathological Analysis in Patients with False Immune Diagnosis of Cystic Echinococcosis, Chen X, Zhang J, Feng X, Chen X, Yin S, Wen H, Zheng S, 2013
Hypoxia preconditioned bone marrow mesenchymal stem cells promote liver regeneration in a rat massive hepatectomy model, Yu J, Yin S, Zhang W, Gao F, Liu Y, Chen Z, Zhang M, He J, Zheng S, 2013
Nanosecond pulsed electric field inhibits cancer growth followed by alteration in expressions of NF-kappaB and Wnt/beta-catenin signaling molecules, Ren Z, Chen X, Cui G, Yin S, Chen L, Jiang J, Hu Z, Xie H, Zheng S, Zhou L, 2013
Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing, Wang H，Chen W，Xie H，Wei X，Yin S，Zhou L，Xu X，Zheng S, 2014
Comparative study of nanosecond electric fields in vitro and in vivo on hepatocellular carcinoma indicate macrophage infiltration contribute to tumor ablation in vivo, Chen X, Yin S, Hu C, Chen X, Jiang K, Ye S, Feng X, Fan S, Xie H, Zhou L, Zheng S, 2014
Nanosecond pulsed electric field (nsPEF) treatment for hepatocellular carcinoma: A novel locoregional ablation decreasing lung metastasis, Yin S, Chen X, Hu C, Zhang X, Hu Z, Yu J, Feng X, Jiang K, Ye S, Shen K, Xie H, Zhou L, James Swanson R, Zheng S, 2014
Association of IGF1R polymorphisms with the development of HBV-related hepatocellular carcinoma, Xie H，Xing C，Wei B，Xu X，Wu J，Chen L，Cao G，Chen H，Chen K，Yin S，Wu L，Zhou L，Zheng S, 2014
Association of RNF43 with cell cycle proteins involved in p53 pathway, Xie H，Xing C，Cao G，Wei B，Xu X，Song P，Chen L，Chen H，Yin S，Zhou L，Zheng S, 2015
Polymorphisms of FGFR1 in HBV-related hepatocellular carcinoma, Xie H，Xing C，Wei B，Xu X，Wu L，Wu J，Chen L，Cao G，Chen H，Meng X，Yin S，Zhou L，Zheng S, 2015
Nanosecond pulsed electric field inhibits proliferation and induces apoptosis in human osteosarcoma, Miao X，Yin S，Shao Z，Zhang Y，Chen X, 2015
Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells, Cheng J，Li W，Kang B，Zhou Y，Song J，Dan S，Yang Y，Zhang X，Li J，Yin S，Cao H，Yao H，Zhu C，Yi W，Zhao Q，Xu X，Zheng M，Zheng S，Li L，Shen B，Wang Y, 2015
Akt-mediated phosphorylation of Oct4 is associated with the proliferation of stem-like cancer cells, Zhao Q，Zhou Y，Li W，Kang B，Zhang X，Yang Y，Cheng J，Yin S，Tong Y，He J，Yao H，Zheng M，Wang Y, 2015
Porta hepatic schwannoma: case report and a 30-year review of the literature yielding 15 cases, Yin S，Zhai, Z，Ren K，Yang Y，Wan D，Liu X，Wang L，Zheng S, 2016
Solanine-induced reactive oxygen species inhibit the growth of human hepatocellular carcinoma HepG2 cells, Meng Xu，Zhang W，Zhang F，Yin S，Xie H，Zhou L，Zheng S, 2016
Cytokine and human leukocyte antigen (HLA) profile for graft-versus-host disease (GVHD) after organ transplantation

Nanosecond Pulsed Electric Field Tumor Ablation Cancer Treatment Biophysics Electroporation Cell Physiology Immunotherapy Liver Cancer Stem Cells Biomedical Engineering

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