Professor | Xiaojun Xu | Asia Growth Partners

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Name	Xiaojun Xu
Contact Information	xiaojunxu@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Xiaojun Xu

Contact Information

xiaojunxu@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Awards	New Century Excellent Talents Program

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Awards

New Century Excellent Talents Program

Areas of Focus	Pharmacology Endocrine Metabolism Traditional Chinese Medicine
Publications	Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice, Chen Y, Wu J, Wang J, Zhang W, Xu B, Xu X, Zong L, 2018 Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway, Zhang M, Qian C, Zheng ZG, Qian F, Wang Y, Thu PM, Zhang X, Zhou Y, Tu L, Liu Q, Li HJ, Yang H, Li P, Xu X, 2018 Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System, Zheng ZG, Zhang X, Liu XX, Jin XX, Dai L, Cheng HM, Jing D, Thu PM, Zhang M, Li H, Zhu J, Liu C, Xue B, Li Y, Chen L, Peng C, Zhu W, Wang L, Liu J, Li HJ, Li P, Xu X, 2019 Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss, Zheng ZG, Cheng HM, Zhou YP, Zhu ST, Thu PM, Li HJ, Li P, Xu X, 2020 The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity, Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J, 2021 Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function, Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y, 2021 Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway, Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X, 2021 Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53, Liu X, Zhang L, Thu PM, Min W, Yang P, Li J, Li P, Xu X, 2021 HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling, Cheng HM, Xing M, Zhou YP, Zhang W, Liu Z, Li L, Zheng Z, Ma Y, Li P, Liu X, Li P, Xu X, 2023 Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer, Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z, Xu X, Gao S, Jiang Y, 2023 Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism, Huang L, Zhang J, Wei B, Chen S, Zhu S, Qi W, Pei X, Li L, Liu W, Wang Y, Xu X, Xie LG, Chen L, 2023 Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice, Zhang W, Lu J, Feng L, Xue H, Shen S, Lai S, Li P, Li P, Kuang J, Yang Z, Xu X, 2024 Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke, Guan X, Zhu S, Song J, Liu K, Liu M, Xie L, Wang Y, Wu J, Xu X, Pang T, 2024

Areas of Focus

Pharmacology
Endocrine Metabolism
Traditional Chinese Medicine

Publications

Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice, Chen Y, Wu J, Wang J, Zhang W, Xu B, Xu X, Zong L, 2018
Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway, Zhang M, Qian C, Zheng ZG, Qian F, Wang Y, Thu PM, Zhang X, Zhou Y, Tu L, Liu Q, Li HJ, Yang H, Li P, Xu X, 2018
Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System, Zheng ZG, Zhang X, Liu XX, Jin XX, Dai L, Cheng HM, Jing D, Thu PM, Zhang M, Li H, Zhu J, Liu C, Xue B, Li Y, Chen L, Peng C, Zhu W, Wang L, Liu J, Li HJ, Li P, Xu X, 2019
Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss, Zheng ZG, Cheng HM, Zhou YP, Zhu ST, Thu PM, Li HJ, Li P, Xu X, 2020
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity, Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J, 2021
Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function, Zhang M, Yang C, Zhu M, Qian L, Luo Y, Cheng H, Geng R, Xu X, Qian C, Liu Y, 2021
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway, Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X, 2021
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53, Liu X, Zhang L, Thu PM, Min W, Yang P, Li J, Li P, Xu X, 2021
HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling, Cheng HM, Xing M, Zhou YP, Zhang W, Liu Z, Li L, Zheng Z, Ma Y, Li P, Liu X, Li P, Xu X, 2023
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer, Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z, Xu X, Gao S, Jiang Y, 2023
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism, Huang L, Zhang J, Wei B, Chen S, Zhu S, Qi W, Pei X, Li L, Liu W, Wang Y, Xu X, Xie LG, Chen L, 2023
Sonic hedgehog-heat shock protein 90β axis promotes the development of nonalcoholic steatohepatitis in mice, Zhang W, Lu J, Feng L, Xue H, Shen S, Lai S, Li P, Li P, Kuang J, Yang Z, Xu X, 2024
Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke, Guan X, Zhu S, Song J, Liu K, Liu M, Xie L, Wang Y, Wu J, Xu X, Pang T, 2024

Lipid Metabolism Pharmacology Endocrine Metabolism Traditional Chinese Medicine Drug Discovery Clinical Research Molecular Biology Metabolic Diseases Therapeutics

Hong Ma - Zhejiang University

Gonghui Li - Zhejiang University

Fangfang Wang - Zhejiang University

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