Professor | Ligen Shi | Asia Growth Partners

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Name	Ligen Shi
Contact Information	slg0904@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Ligen Shi

Contact Information

slg0904@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Awards	National Excellent Youth Zhejiang Provincial Excellent Youth

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Awards

National Excellent Youth
Zhejiang Provincial Excellent Youth

Areas of Focus	Immunotherapy for cerebrovascular diseases Interaction between the immune system and the nervous system Role of microglia in brain aging and white matter repair after ischemic stroke Protective mechanisms of regulatory T cells in ischemic stroke Development of single-cell RNA sequencing data analysis tools
Publications	Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke, Ligen Shi, Zeyu Sun, Wei Su, Fei Xu, Di Xie, Qingxiu Zhang, Xuejiao Dai, Kartik Iyer, T. Kevin Hitchens, Lesley M. Foley, Sicheng Li, Donna B. Stolz, Kong Chen, Ying Ding, Angus W. Thomson, Rehana K. Leak, Jun Chen, Xiaoming Hu, 2021 InterCellDB: A User-Defined Database for Inferring Intercellular Networks, Ziyang Jin, Xiaotao Zhang, Xuejiao Dai, Jinyan Huang, Xiaoming Hu, Jianmin Zhang, Ligen Shi, 2022 Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice, Wei Cai, Ligen Shi, Jingyan Zhao, Fei Xu, Connor Dufort, Qing Ye, Tuo Yang, Xuejiao Dai, Junxuan Lyu, Chenghao Jin, Hongjian Pu, Fang Yu, Sulaiman Hassan, Zeyu Sun, Wenting Zhang, T. Kevin Hitchens, Yejie Shi, Angus W. Thomson, Rehana K. Leak, Xiaoming Hu, Jun Chen, 2022 A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice, Chenhao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi, 2021 Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia, Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H. Hassanm, Liqiang Liu, Maya N. Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R. Wechsler, Jun Chen, Yejie Shi, 2020

Areas of Focus

Immunotherapy for cerebrovascular diseases
Interaction between the immune system and the nervous system
Role of microglia in brain aging and white matter repair after ischemic stroke
Protective mechanisms of regulatory T cells in ischemic stroke
Development of single-cell RNA sequencing data analysis tools

Publications

Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke, Ligen Shi, Zeyu Sun, Wei Su, Fei Xu, Di Xie, Qingxiu Zhang, Xuejiao Dai, Kartik Iyer, T. Kevin Hitchens, Lesley M. Foley, Sicheng Li, Donna B. Stolz, Kong Chen, Ying Ding, Angus W. Thomson, Rehana K. Leak, Jun Chen, Xiaoming Hu, 2021
InterCellDB: A User-Defined Database for Inferring Intercellular Networks, Ziyang Jin, Xiaotao Zhang, Xuejiao Dai, Jinyan Huang, Xiaoming Hu, Jianmin Zhang, Ligen Shi, 2022
Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice, Wei Cai, Ligen Shi, Jingyan Zhao, Fei Xu, Connor Dufort, Qing Ye, Tuo Yang, Xuejiao Dai, Junxuan Lyu, Chenghao Jin, Hongjian Pu, Fang Yu, Sulaiman Hassan, Zeyu Sun, Wenting Zhang, T. Kevin Hitchens, Yejie Shi, Angus W. Thomson, Rehana K. Leak, Xiaoming Hu, Jun Chen, 2022
A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice, Chenhao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi, 2021
Genome-wide transcriptomic analysis of microglia reveals impaired responses in aged mice after cerebral ischemia, Ligen Shi, Marcelo Rocha, Wenting Zhang, Ming Jiang, Sicheng Li, Qing Ye, Sulaiman H. Hassanm, Liqiang Liu, Maya N. Adair, Jing Xu, Jianhua Luo, Xiaoming Hu, Lawrence R. Wechsler, Jun Chen, Yejie Shi, 2020

Immunotherapy Cerebrovascular Diseases Immune System Nervous System Microglia Brain Aging White Matter Repair Ischemic Stroke Regulatory T Cells Rna Sequencing

Xia Dajing - Zhejiang University

Qian Wu - Zhejiang University

Jiang Penglei - Zhejiang University

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