Professor | Xiukui Gao | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Xiukui Gao
Contact Information	gaoxiukui@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Xiukui Gao

Contact Information

gaoxiukui@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2011-2015 Bachelor's Degree in Biological Sciences: Soochow University 2015-2020 Combined Master's and Ph.D. in Biochemistry and Molecular Biology: Zhejiang University First to discover that liquid-liquid phase separation (LLPS) regulates the Insulin/IGF-1 signaling pathway and revealed the association between phase separation disorder and metabolic diseases Discovered a novel membraneless organelle (IRS-1 condensate) interacting with the endoplasmic reticulum to regulate signal transduction, revealing insulin resistance as a potential pathogenic mechanism of ALS
Work Experience	2020-2022 - Zhejiang University - Postdoctoral Researcher 2022-present - The Fourth Affiliated Hospital, Zhejiang University School of Medicine - Distinguished Researcher
Awards	National Scholarship for Undergraduates (2014) Outstanding Graduate of Soochow University (2015) National Scholarship for Doctoral Students (2020) Outstanding Graduate of Zhejiang University (2020) New Star Youth Research Forum Award, Zhejiang Biochemical Conference (2021)

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2011-2015 Bachelor's Degree in Biological Sciences: Soochow University
2015-2020 Combined Master's and Ph.D. in Biochemistry and Molecular Biology: Zhejiang University
First to discover that liquid-liquid phase separation (LLPS) regulates the Insulin/IGF-1 signaling pathway and revealed the association between phase separation disorder and metabolic diseases
Discovered a novel membraneless organelle (IRS-1 condensate) interacting with the endoplasmic reticulum to regulate signal transduction, revealing insulin resistance as a potential pathogenic mechanism of ALS

Work Experience

2020-2022 - Zhejiang University - Postdoctoral Researcher
2022-present - The Fourth Affiliated Hospital, Zhejiang University School of Medicine - Distinguished Researcher

Awards

National Scholarship for Undergraduates (2014)
Outstanding Graduate of Soochow University (2015)
National Scholarship for Doctoral Students (2020)
Outstanding Graduate of Zhejiang University (2020)
New Star Youth Research Forum Award, Zhejiang Biochemical Conference (2021)

Areas of Focus	Organelle Homeostasis and Autophagy Biological Phase Separation and Signal Transduction
Publications	VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling, Gao, X. K., Sheng, Z. K., Lu, Y. H., Sun, Y. T., Rao, X. S., Shi, L. J., Cong, X. X., Chen X., Wu, H. B., Huang, M., Zheng, Q., Guo, J. S., Jiang, L. J., Zheng, L. L., Zhou, Y. T., 2023 Phase separation of Insulin Receptor Substrate 1 drives the formation of insulin/IGF-1 signalosomes, Gao, X. K., Rao, X. S., Cong, X. X., Sheng, Z. K., Sun, Y. T., Xu, S. B., Wang, J. F., Liang, Y. H., Lu, L. R., Ouyang, H. W., Ge, H. Q., Guo, J. S., Wu, H. J., Sun, Q. M., Wu, H. B., Bao, Z., Zheng, L.L., Zhou, Y. T., 2022 AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake, Rao, X.S., Cong, X.X., Gao, X.K., Shi, Y.P., Shi, L.J., Wang, J.F., Ni, C.Y., He, M.J., Xu, Y., Yi, C., Meng, Z.X., Liu, J., Lin, P., Zheng, L.L., Zhou, Y.T., 2021 Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration, Cong, X.X., Gao, X.K., Rao, X.S., Wen, J., Liu, X.C., Shi, Y.P., He, M.Y., Shen, W.L., Shen, Y., Ouyang, H., Hu, P., Low, B.C., Meng, Z.X., Ke, Y.H., Zheng, M.Z., Lu, L.R., Liang, Y.H., Zheng, L.L., Zhou,Y.T., 2020 Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration, Fan, W., Gao, X.K., Rao, X.S., Shi, Y.P., Liu, X.C., Wang, F.Y., Liu, Y.F., Cong, X.X., He, M.Y., Xu, S.B., Shen, W.L., Shen, Y., Yan, S.G., Luo, Y., Low, B.C., Ouyang, H., Bao, Z., Zheng, L.L., Zhou,Y.T., 2018 Triptolide induces atrophy of myotubes by triggering IRS-1 degradation and activating the FoxO3 pathway, Wang, J., Gao, X., Ren, D., Zhang, M., Zhang, P., Lu, S., Huan, C., Yao, Y., Zheng, L., Bao, Z., Zhou, J., 2020

Areas of Focus

Organelle Homeostasis and Autophagy
Biological Phase Separation and Signal Transduction

Publications

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling, Gao, X. K., Sheng, Z. K., Lu, Y. H., Sun, Y. T., Rao, X. S., Shi, L. J., Cong, X. X., Chen X., Wu, H. B., Huang, M., Zheng, Q., Guo, J. S., Jiang, L. J., Zheng, L. L., Zhou, Y. T., 2023
Phase separation of Insulin Receptor Substrate 1 drives the formation of insulin/IGF-1 signalosomes, Gao, X. K., Rao, X. S., Cong, X. X., Sheng, Z. K., Sun, Y. T., Xu, S. B., Wang, J. F., Liang, Y. H., Lu, L. R., Ouyang, H. W., Ge, H. Q., Guo, J. S., Wu, H. J., Sun, Q. M., Wu, H. B., Bao, Z., Zheng, L.L., Zhou, Y. T., 2022
AMPK-mediated phosphorylation enhances the auto-inhibition of TBC1D17 to promote Rab5-dependent glucose uptake, Rao, X.S., Cong, X.X., Gao, X.K., Shi, Y.P., Shi, L.J., Wang, J.F., Ni, C.Y., He, M.J., Xu, Y., Yi, C., Meng, Z.X., Liu, J., Lin, P., Zheng, L.L., Zhou, Y.T., 2021
Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration, Cong, X.X., Gao, X.K., Rao, X.S., Wen, J., Liu, X.C., Shi, Y.P., He, M.Y., Shen, W.L., Shen, Y., Ouyang, H., Hu, P., Low, B.C., Meng, Z.X., Ke, Y.H., Zheng, M.Z., Lu, L.R., Liang, Y.H., Zheng, L.L., Zhou,Y.T., 2020
Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle Regeneration, Fan, W., Gao, X.K., Rao, X.S., Shi, Y.P., Liu, X.C., Wang, F.Y., Liu, Y.F., Cong, X.X., He, M.Y., Xu, S.B., Shen, W.L., Shen, Y., Yan, S.G., Luo, Y., Low, B.C., Ouyang, H., Bao, Z., Zheng, L.L., Zhou,Y.T., 2018
Triptolide induces atrophy of myotubes by triggering IRS-1 degradation and activating the FoxO3 pathway, Wang, J., Gao, X., Ren, D., Zhang, M., Zhang, P., Lu, S., Huan, C., Yao, Y., Zheng, L., Bao, Z., Zhou, J., 2020

Organelle Homeostasis Autophagy Biological Phase Separation Signal Transduction Insulin Signaling Igf-1 Signaling Metabolic Diseases Membraneless Organelles Irs-1 Condensate Als

Wei Liu - Zhejiang University

Cong Yi - Zhejiang University

Linfu Zhou - Zhejiang University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us