Professor | Xiongwen Cao | Asia Growth Partners

Name	Xiongwen Cao
Contact Information	xwcao@bio.ecnu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Xiongwen Cao

Contact Information

xwcao@bio.ecnu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	East China Normal University
Faculty	Life Sciences
Academic Background & Achievements	2005.9 - 2009.6: Bachelor in Biotechnology, Huazhong University of Science and Technology 2009.9 - 2015.12: PhD in Biochemistry and Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Work Experience	2023.1 - Present: Researcher, East China Normal University 2019.2 - 2022.12: Postdoctoral Fellow, Department of Chemistry, Yale University 2015.12 - 2019.1: Postdoctoral Fellow, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Awards	2022: Shanghai Pujiang Talent 2022: Zijiang Young Scholar

University/Lab Affiliation and Title

East China Normal University

Faculty

Life Sciences

Academic Background & Achievements

2005.9 - 2009.6: Bachelor in Biotechnology, Huazhong University of Science and Technology
2009.9 - 2015.12: PhD in Biochemistry and Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

Work Experience

2023.1 - Present: Researcher, East China Normal University
2019.2 - 2022.12: Postdoctoral Fellow, Department of Chemistry, Yale University
2015.12 - 2019.1: Postdoctoral Fellow, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences

Awards

2022: Shanghai Pujiang Talent
2022: Zijiang Young Scholar

Areas of Focus	Unannotated microproteins in human genome Development of proteomics methods Discovery and functional study of unannotated microproteins
Publications	Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5, Xiongwen Cao, Yanran Chen, Haomiao Su, Jianing Zhao, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Zhentian Wang, Sarah A. Slavoff, 2023 Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides, Yanran Chen, Xiongwen Cao, Ken H. Loh, Sarah A. Slavoff, 2023 BONCAT-based Profiling of Nascent Small and Alternative Open Reading Frame-encoded Proteins, Xiongwen Cao, Yanran Chen, Alexandra Khitun, Sarah A. Slavoff, 2023 Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor, Xiongwen Cao, Alexandra Khitun, Cecelia M. Harold, Carson J. Bryant, Shu-Jian Zheng, Susan J. Baserga, Sarah A. Slavoff, 2022 Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID, Zhenkun Na, Xiaoyun Dai, Shu-Jian Zheng, Carson J. Bryant, Ken H. Loh, Haomiao Su, Yang Luo, Amber F. Buhagiar, Xiongwen Cao, Susan J. Baserga, Sidi Chen, Sarah A. Slavoff, 2022 Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24, Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff, 2021 Comparative Proteomic Profiling of Unannotated Microproteins and Alternative Proteins in Human Cell Lines, Xiongwen Cao, Alexandra Khitun, Zhenkun Na, Daniel G. Dumitrescu, Marcelina Kubica, Elizabeth Olatunji, Sarah A. Slavoff, 2020 Non-AUG start codons: Expanding and regulating the small and alternative ORFeome, Xiongwen Cao, Sarah A. Slavoff, 2020 Histone H4K20 Demethylation by Two hHR23 Proteins, Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen, 2020 Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram, Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu, Charlie Degui Chen, 2015 Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen, Jin-Qiu Zhou, 2015 Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway, Chunyu Jin, Jing Li, Christopher D. Green, Xiaoming Yu, Xia Tang, Dali Han, Bo Xian, Dan Wang, Xinxin Huang, Xiongwen Cao, Zheng Yan, Lei Hou, Jiancheng Liu, Nicholas Shukeir, Philipp Khaitovich, Charlie D. Chen, Hong Zhang, Thomas Jenuwein, Jing-Dong J. Han, 2011

Areas of Focus

Unannotated microproteins in human genome
Development of proteomics methods
Discovery and functional study of unannotated microproteins

Publications

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5, Xiongwen Cao, Yanran Chen, Haomiao Su, Jianing Zhao, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Zhentian Wang, Sarah A. Slavoff, 2023
Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides, Yanran Chen, Xiongwen Cao, Ken H. Loh, Sarah A. Slavoff, 2023
BONCAT-based Profiling of Nascent Small and Alternative Open Reading Frame-encoded Proteins, Xiongwen Cao, Yanran Chen, Alexandra Khitun, Sarah A. Slavoff, 2023
Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor, Xiongwen Cao, Alexandra Khitun, Cecelia M. Harold, Carson J. Bryant, Shu-Jian Zheng, Susan J. Baserga, Sarah A. Slavoff, 2022
Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID, Zhenkun Na, Xiaoyun Dai, Shu-Jian Zheng, Carson J. Bryant, Ken H. Loh, Haomiao Su, Yang Luo, Amber F. Buhagiar, Xiongwen Cao, Susan J. Baserga, Sidi Chen, Sarah A. Slavoff, 2022
Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24, Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff, 2021
Comparative Proteomic Profiling of Unannotated Microproteins and Alternative Proteins in Human Cell Lines, Xiongwen Cao, Alexandra Khitun, Zhenkun Na, Daniel G. Dumitrescu, Marcelina Kubica, Elizabeth Olatunji, Sarah A. Slavoff, 2020
Non-AUG start codons: Expanding and regulating the small and alternative ORFeome, Xiongwen Cao, Sarah A. Slavoff, 2020
Histone H4K20 Demethylation by Two hHR23 Proteins, Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen, 2020
Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram, Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu, Charlie Degui Chen, 2015
Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen, Jin-Qiu Zhou, 2015
Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway, Chunyu Jin, Jing Li, Christopher D. Green, Xiaoming Yu, Xia Tang, Dali Han, Bo Xian, Dan Wang, Xinxin Huang, Xiongwen Cao, Zheng Yan, Lei Hou, Jiancheng Liu, Nicholas Shukeir, Philipp Khaitovich, Charlie D. Chen, Hong Zhang, Thomas Jenuwein, Jing-Dong J. Han, 2011

Genomics Proteomics Microproteins Biomarkers Cancer Cell Metabolism Mass Spectrometry Bioinformatics Molecular Biology Cell Communication

Qi Liu - Tongji University

Lu Dongdong - Tongji University

Zhiwei Cao - Tongji University

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