Areas of Focus
- Unannotated microproteins in human genome
- Development of proteomics methods
- Discovery and functional study of unannotated microproteins
Work Experience
- 2023.1 - Present: Researcher, East China Normal University
- 2019.2 - 2022.12: Postdoctoral Fellow, Department of Chemistry, Yale University
- 2015.12 - 2019.1: Postdoctoral Fellow, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
Academic Background & Achievements
- 2005.9 - 2009.6: Bachelor in Biotechnology, Huazhong University of Science and Technology
- 2009.9 - 2015.12: PhD in Biochemistry and Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Publications
- Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5, Xiongwen Cao, Yanran Chen, Haomiao Su, Jianing Zhao, Zhenkun Na, Kevin Jiang, Antonella Bacchiocchi, Ken H. Loh, Ruth Halaban, Zhentian Wang, Sarah A. Slavoff, 2023
- Chemical labeling and proteomics for characterization of unannotated small and alternative open reading frame-encoded polypeptides, Yanran Chen, Xiongwen Cao, Ken H. Loh, Sarah A. Slavoff, 2023
- BONCAT-based Profiling of Nascent Small and Alternative Open Reading Frame-encoded Proteins, Xiongwen Cao, Yanran Chen, Alexandra Khitun, Sarah A. Slavoff, 2023
- Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor, Xiongwen Cao, Alexandra Khitun, Cecelia M. Harold, Carson J. Bryant, Shu-Jian Zheng, Susan J. Baserga, Sarah A. Slavoff, 2022
- Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID, Zhenkun Na, Xiaoyun Dai, Shu-Jian Zheng, Carson J. Bryant, Ken H. Loh, Haomiao Su, Yang Luo, Amber F. Buhagiar, Xiongwen Cao, Susan J. Baserga, Sidi Chen, Sarah A. Slavoff, 2022
- Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24, Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff, 2021
- Comparative Proteomic Profiling of Unannotated Microproteins and Alternative Proteins in Human Cell Lines, Xiongwen Cao, Alexandra Khitun, Zhenkun Na, Daniel G. Dumitrescu, Marcelina Kubica, Elizabeth Olatunji, Sarah A. Slavoff, 2020
- Non-AUG start codons: Expanding and regulating the small and alternative ORFeome, Xiongwen Cao, Sarah A. Slavoff, 2020
- Histone H4K20 Demethylation by Two hHR23 Proteins, Xiongwen Cao, Yanran Chen, Bin Wu, Xiaoyun Wang, Hongjuan Xue, Lu Yu, Jie Li, Yiqin Wang, Wei Wang, Qing Xu, Hailei Mao, Chao Peng, Gang Han, Charlie Degui Chen, 2020
- Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram, Hailei Mao, Gang Han, Longyong Xu, Duming Zhu, Hanqing Lin, Xiongwen Cao, Yi Yu, Charlie Degui Chen, 2015
- Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen, Jin-Qiu Zhou, 2015
- Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway, Chunyu Jin, Jing Li, Christopher D. Green, Xiaoming Yu, Xia Tang, Dali Han, Bo Xian, Dan Wang, Xinxin Huang, Xiongwen Cao, Zheng Yan, Lei Hou, Jiancheng Liu, Nicholas Shukeir, Philipp Khaitovich, Charlie D. Chen, Hong Zhang, Thomas Jenuwein, Jing-Dong J. Han, 2011
Awards
- 2022: Shanghai Pujiang Talent
- 2022: Zijiang Young Scholar
