Upload Avatar (500 x 500)
Lei Liu
Zoology
Chinese Academy of Sciences
Beijing
Language: Chinese, English
Mitophagy
Fundc1
Organelle
Homeostasis
Disease
Molecular Mechanism
Physiology
Pathology
Mitochondria
Quality Control
Areas of Focus
- Regulation of mitochondrial and other organelle homeostasis and disease
Work Experience
- Researcher at the State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Academic Background & Achievements
- Identified a new mammalian mitophagy receptor protein FUNDC1
- Published over 30 SCI papers
- First or corresponding author in journals like Nature Cell Biology, EMBO Journal
Publications
- Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy, Wu H, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L, Chen Q, 2020
- Mitophagy and its contribution to metabolic and aging associated disorders, Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q, 2020
- Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome, Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q, 2019
- A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity, Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L, Chen Q, 2019
- STING directly activates autophagy to tune the innate immune response, Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y, Jiang Z, Liu L, Chen Q, 2019
- Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy, Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L, Chen Q, 2016
- The Bcl-xL and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy, Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L, Chen Q, 2014
- Receptor-mediated mitophagy in yeast and mammalian systems, Liu L, Sakakibara K, Chen Q, Okamoto K, 2014
- Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells, Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q, 2012
Awards
- Lu Jiaxi Young Talent Award (2014)
