Professor | Weiwei Zhai | Asia Growth Partners

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Name	Weiwei Zhai
Contact Information	weiweizhai@ioz.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Weiwei Zhai

Contact Information

weiweizhai@ioz.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2002 - Bachelor's Degree in Biology: University of Science and Technology of China 2004 - Master's Degree in Biostatistics: Cornell University 2008 - Ph.D. in Population Genetics: University of California, Berkeley
Work Experience	2009-06 to 2013-09 - Associate Researcher at Beijing Institute of Genomics, Chinese Academy of Sciences 2013-09 to 2018-06 - Principal Investigator at Genome Institute of Singapore 2018-06 to Present - Researcher at Institute of Zoology, Chinese Academy of Sciences
Awards	2019: Top Ten Advances in Chinese Medical Biotechnology 2017: Sanofi-Cell Research Outstanding Paper Award of 2016 (joint work on dog evolution) 2012: Youth Innovation Promotion Association of the Chinese Academy of Sciences 2010: AAAS Newcomb Cleveland Prize (Joint work on the Neanderthal project)

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2002 - Bachelor's Degree in Biology: University of Science and Technology of China
2004 - Master's Degree in Biostatistics: Cornell University
2008 - Ph.D. in Population Genetics: University of California, Berkeley

Work Experience

2009-06 to 2013-09 - Associate Researcher at Beijing Institute of Genomics, Chinese Academy of Sciences
2013-09 to 2018-06 - Principal Investigator at Genome Institute of Singapore
2018-06 to Present - Researcher at Institute of Zoology, Chinese Academy of Sciences

Awards

2019: Top Ten Advances in Chinese Medical Biotechnology
2017: Sanofi-Cell Research Outstanding Paper Award of 2016 (joint work on dog evolution)
2012: Youth Innovation Promotion Association of the Chinese Academy of Sciences
2010: AAAS Newcomb Cleveland Prize (Joint work on the Neanderthal project)

Areas of Focus	Somatic Evolution and Cancer Genomics Methodologies for Detecting Adaptive Evolution Population Genetics of Natural Species
Publications	A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory., Chen J, et al, Tam WL#, Zhai W#, Chow PK#, 2024 Tumor phylogeography revealed block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma., Liu X et al, Ma, L#, Jiang, L#, Zhai, W#, 2024 Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma., Kaya NA, Tai D#,, Lim X, Lim JQ, Lau MC, Goh D, Phua CZJ, Wee FYT, Joseph CR, Lim JCT, Neo ZW, Ye J, Cheung L, Lee J, Loke KSH, Gogna A, Yao F, Lee MY, Shuen TWH, Toh HC, Hilmer A, Chan YS, Lim TK, Tam WL, Choo SP, Yeong J#, Zhai W#, 2023 SONAR enables cell type deconvolution with spatially weighted Poisson-Gamma model for spatial transcriptomics., Liu Z, Wu D, Zhai W#, Ma L#, 2023 Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study., Zhai W,#, Lai H, Kaya N, Chen J, Yang H, Lu B, et al. Chow PKH#, 2022 Genomic landscape of lung adenocarcinoma in East Asians., Chen J, Yang H, Teo ASM, Amer LB, Sherbaf FG, Tan CQ, Alvarez JJS, Lu B, Lim JQ, Takano A, Nahar R, Lee YY, Phua CZJ, Chua KP, Suteja L, Chen PJ, Chang MM, Koh TPT, Ong BH, Anantham D, Hsu AAL, Gogna A, Too CW, Aung ZW, Lee YF, Wang L, Lim TKH, Wilm A, Choi PS, Ng PY, Toh CK, Lim WT, Ma S, Lim B, Liu J, Tam WL, Skanderup AJ, Yeong JPS, Tan EH, Creasy CL, Tan DSW#, Hillmer AM#, Zhai W#, 2020 Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma., Xu M, Yao Y, Chen H, Zhang S, et al Zhai W#, Zeng YX#, Liu J#, 2019 Passage adaptation correlates with the reduced efficacy of the influenza vaccine., Chen H, Alvarez JJS, Ng SH, Nielsen R, Zhai W, 2019 The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma., Zhai W,#, Lim TK, Zhang T, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS#, Chow PK#, 2017 Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution., Chen H, Deng Q, Ng SH, Lee RT, Maurer-Stroh S, Zhai W, 2016 Out of southern East Asia: the natural history of domestic dogs across the world., Wang GD, Zhai W, Yang HC, Wang L, Zhong L, Liu YH, Fan RX, Yin TT, Zhu CL, Poyarko v AD, Irwin DM, Hytonen MK, Lohi H, Wu CI, Savolainen P#, Zhang YP#, 2015 Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis., Hu Z, Fu YX, Greenberg AJ, Wu CI#, Zhai W#, 2013 Looking for Darwin in genomic sequences--validity and success of statistical methods., Zhai W, Nielsen R, Goldman N, Yang Z, 2012 A draft sequence of the Neandertal genome., Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, Patterson N*, Li H, Zhai W, Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T, Alkan C, Prüfer K, Meyer M, Burbano HA, Good JM, Schultz R, Aximu-Petri A, Butthof A, Hober B, Hoffner B, Siegemund M, Weihmann A, Nusbaum C, Lander ES, Russ C, Novod N, Affourtit J, Egholm M, Verna C, Rudan P, Brajkovic D, Kucan Z, Gusic I, Doronichev VB, Golovanova LV, Lalueza-Fox C, de la Rasilla M, Fortea J, Rosas A, Schmitz RW, Johnson PL, Eichler EE, Falush D, Birney E, Mullikin JC, Slatkin M, Nielsen R, Kelso J, Lachmann M, Reich D, Paabo S, 2010 An investigation of the statistical power of neutrality tests based on comparative and population genetic data., Zhai W, Nielsen R, Slatkin M, 2008

Areas of Focus

Somatic Evolution and Cancer Genomics
Methodologies for Detecting Adaptive Evolution
Population Genetics of Natural Species

Publications

A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and ‘bad apple’ effect on clinical trajectory., Chen J, et al, Tam WL#, Zhai W#, Chow PK#, 2024
Tumor phylogeography revealed block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma., Liu X et al, Ma, L#, Jiang, L#, Zhai, W#, 2024
Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma., Kaya NA*, Tai D#,*, Lim X*, Lim JQ, Lau MC, Goh D, Phua CZJ, Wee FYT, Joseph CR, Lim JCT, Neo ZW, Ye J, Cheung L, Lee J, Loke KSH, Gogna A, Yao F, Lee MY, Shuen TWH, Toh HC, Hilmer A, Chan YS, Lim TK, Tam WL, Choo SP, Yeong J#, Zhai W#, 2023
SONAR enables cell type deconvolution with spatially weighted Poisson-Gamma model for spatial transcriptomics., Liu Z, Wu D, Zhai W#, Ma L#, 2023
Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in Hepatocellular Carcinoma: the PLANET study., Zhai W*,#, Lai H*, Kaya N*, Chen J*, Yang H*, Lu B*, et al. Chow PKH#, 2022
Genomic landscape of lung adenocarcinoma in East Asians., Chen J, Yang H, Teo ASM, Amer LB, Sherbaf FG, Tan CQ, Alvarez JJS, Lu B, Lim JQ, Takano A, Nahar R, Lee YY, Phua CZJ, Chua KP, Suteja L, Chen PJ, Chang MM, Koh TPT, Ong BH, Anantham D, Hsu AAL, Gogna A, Too CW, Aung ZW, Lee YF, Wang L, Lim TKH, Wilm A, Choi PS, Ng PY, Toh CK, Lim WT, Ma S, Lim B, Liu J, Tam WL, Skanderup AJ, Yeong JPS, Tan EH, Creasy CL, Tan DSW#, Hillmer AM#, Zhai W#, 2020
Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma., Xu M*, Yao Y*, Chen H*, Zhang S*, et al Zhai W#, Zeng YX#, Liu J#, 2019
Passage adaptation correlates with the reduced efficacy of the influenza vaccine., Chen H, Alvarez JJS, Ng SH, Nielsen R, Zhai W, 2019
The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma., Zhai W*,#, Lim TK*, Zhang T*, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS#, Chow PK#, 2017
Dynamic Convergent Evolution Drives the Passage Adaptation across 48 Years' History of H3N2 Influenza Evolution., Chen H, Deng Q, Ng SH, Lee RT, Maurer-Stroh S, Zhai W, 2016
Out of southern East Asia: the natural history of domestic dogs across the world., Wang GD*, Zhai W*, Yang HC*, Wang L*, Zhong L, Liu YH, Fan RX, Yin TT, Zhu CL, Poyarko v AD, Irwin DM, Hytonen MK, Lohi H, Wu CI, Savolainen P#, Zhang YP#, 2015
Age-dependent transition from cell-level to population-level control in murine intestinal homeostasis revealed by coalescence analysis., Hu Z, Fu YX, Greenberg AJ, Wu CI#, Zhai W#, 2013
Looking for Darwin in genomic sequences--validity and success of statistical methods., Zhai W, Nielsen R, Goldman N, Yang Z, 2012
A draft sequence of the Neandertal genome., Green RE*, Krause J*, Briggs AW*, Maricic T*, Stenzel U*, Kircher M*, Patterson N*, Li H, Zhai W, Fritz MH, Hansen NF, Durand EY, Malaspinas AS, Jensen JD, Marques-Bonet T, Alkan C, Prüfer K, Meyer M, Burbano HA, Good JM, Schultz R, Aximu-Petri A, Butthof A, Hober B, Hoffner B, Siegemund M, Weihmann A, Nusbaum C, Lander ES, Russ C, Novod N, Affourtit J, Egholm M, Verna C, Rudan P, Brajkovic D, Kucan Z, Gusic I, Doronichev VB, Golovanova LV, Lalueza-Fox C, de la Rasilla M, Fortea J, Rosas A, Schmitz RW, Johnson PL, Eichler EE, Falush D, Birney E, Mullikin JC, Slatkin M, Nielsen R, Kelso J, Lachmann M, Reich D, Paabo S, 2010
An investigation of the statistical power of neutrality tests based on comparative and population genetic data., Zhai W, Nielsen R, Slatkin M, 2008

Somatic Evolution Cancer Genomics Adaptive Evolution Population Genetics Genomics Molecular Evolution Computational Biology Tumor Evolution Genetic Diversity Evolutionary Dynamics

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