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Chen Xin
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: English, Chinese
Cell Death
Regulation
Mechanisms
Drug Development
Ferroptosis
Diseases
Autophagy
Cancer
Health
Therapy
Areas of Focus
- New regulatory mechanisms of cell death and related drug development
- Ferroptosis and diseases
Academic Background & Achievements
- PhD in Oncology
- Visiting scholar at the University of Texas Southwestern Medical Center
- Published multiple SCI papers as first/corresponding author in journals like Nature Communications
Publications
- A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis., Chen X, Huang J, Yu C, Liu J, Gao W, Li J, Song X, Zhou Z, Li C, Xie Y, Kroemer G, Liu J, Tang D, Kang R., 2022
- Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis., Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky D, Kroemer G, Liu J, Tang D, Kang R., 2022
- Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30., Yan D, Li X, Yang Q, Huang Q, Yao L, Zhang P, Sun W, Lin S, Dou Q, Liu J, Chen X., 2021
- International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis., Chen X, Tsvetkov A, Shen H, Isidoro C, Ktistakis N, Linkermann A, Koopman W, Simon H, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein D, Chi J, Zhang D, Li C, Toyokuni S, Liu J, Roh J, Dai E, Juhasz G, Liu W, Zhang J, Yang M, Liu J, Zhu L, Zou W, Piacentini M, Ding W, Yue Z, Xie Y, Petersen M, Gewirtz D, Mandell M, Chu C, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich D, Kim D, Kagan V, Bayir H, Chen G, Ayton S, Lünemann J, Komatsu M, Krautwald S, Loos B, Baehrecke E, Wang J, Lane J, Sadoshima J, Yang W, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski M, Jones J, Jiang X, Zeh H, Kang R, Klionsky D, Kroemer G, Tang D., 2024
- Copper metabolism in cell death and autophagy., Xue Q, Kang R, Klionsky D, Tang D, Liu J, Chen X., 2023
- Copper-dependent autophagic degradation of GPX4 drives ferroptosis., Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky D, Kroemer G, Chen X, Tang D, Liu J., 2023
- The role of ferroptosis in lung cancer., Wu S, Zhu C, Tang D, Dou Q, Shen J, Chen X., 2021
- The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability., Yang Q, Yan D, Zou C, Xue Q, Lin S, Huang Q, Li X, Tang D, Chen X, Liu J., 2022
- Broadening horizons: the role of ferroptosis in cancer., Chen X, Kang R, Kroemer G, Tang D., 2021
- Cell death in pancreatic cancer: from pathogenesis to therapy., Chen X, Kang R, Zeh H, Kroemer G, Tang D., 2021
Awards
- 2016: Guangzhou Science and Technology Award First Prize
- 2017: Guangzhou Medical University Publication Strength Award and Citation Laureate Award
- 2020: Ministry of Education Higher Education Scientific Research Outstanding Achievement Award (Natural Science) Second Prize
- 2022: Guangzhou Medical Association Excellent Academic Paper Second Prize
- 2023: Guangzhou Medical University Fourth 'Functional Experiment Design Competition' Excellence Award
- 2023: Guangzhou Medical University School of Basic Medicine Teacher's Day Style Selection Activity Excellent Teacher
- 2023: Global Top 2% Scientist
