Professor | Wenbing Chen | Asia Growth Partners

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Name	Wenbing Chen
Contact Information	chenwenbing@gzhmu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Wenbing Chen

Contact Information

chenwenbing@gzhmu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2020 - PhD: Nanchang University 2016-2018 - Joint PhD Training: Augusta University/Case Western Reserve University Postdoctoral Research: Nanchang University (2020-2023)
Work Experience	2023-Present - Guangzhou Medical University - Professor and Research Group Leader 2020-2023 - Nanchang University - Postdoctoral Researcher
Awards	Nanshan Scholar Core Talent National Natural Science Foundation Youth Project China Postdoctoral Science Foundation First-Class Funding

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2020 - PhD: Nanchang University
2016-2018 - Joint PhD Training: Augusta University/Case Western Reserve University
Postdoctoral Research: Nanchang University (2020-2023)

Work Experience

2023-Present - Guangzhou Medical University - Professor and Research Group Leader
2020-2023 - Nanchang University - Postdoctoral Researcher

Awards

Nanshan Scholar Core Talent
National Natural Science Foundation Youth Project
China Postdoctoral Science Foundation First-Class Funding

Areas of Focus	Circuit and molecular mechanisms of anxiety disorders and depression Role and mechanisms of extracellular matrix in the central nervous system Role and mechanisms of glial cells in the pathogenesis of mental disorders
Publications	Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models, W.B. Chen, B. Luo, N.N. Gao, H.W. Li, H.S. Wang, L. Li, W.P. Cui, L. Zhang, D. Sun, F. Liu, Z.Q. Dong, X. Ren, H.S. Zhang, H. B. Su, W.C. Xiong, and L. Mei#, 2021 A novel spinal neuron connection for heat sensation, H.S. Wang, W.B. Chen, Z.Q. Dong, G.L. Xing, W.P. Cui, L.L. Yao, W.J. Zou, H. Robinson, Y.Y. Bian, Z.P. Liu, K. Zhao, B. Luo, N.N. Gao, H.S. Zhang, X. Ren, Z. Yu, J. Meixiong, W.C. Xiong and L. Mei#, 2022 CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of Cap-dependent translation, Z.Q. Dong, W.B. Chen, C. Chen, H.S. Wang, W.P. Cui, Z.B. Tan, H. Robinson, N.N. Gao, B. Luo, L. Zhang, K. Zhao, W.C. Xiong and L. Mei#, 2020 Rap1b but not Rap1a in the forebrain is required for learned fear, W.B. Chen, H.Q. Pan, Y. He, X.H. Wang, W.H. Zhang, and B.X. Pan#, 2020 DiGeorge syndrome critical region gene 2 (DGCR2), a schizophrenia risk gene, regulates dendritic spine development through cell adhesion, D.Y. Ren, B. Luo, P. Chen, L.L. Yu, M.T. Xiong, Z.Q. Fu, T. Zhou, W.B. Chen# and E.K. Fei#, 2023 LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity, D. Lin, L.H. Li, W.B. Chen, J. Chen, D.Y. Ren, Z.H. Zheng, C.Q. Zhao, Y.Z. Zhong, B. Luo, H.Y. Jing, P. Chen, S.Q. Zou, X.S. Lai, T. Zhou, N. Ding, L. Li, B.X. Pan#, E.K. Fei#, 2023 The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons, H.S. Wang, W.P. Cui, W.B. Chen, F. Liu, Z.Q. Dong, G.L. Xing, B. Luo, N.N. Gao, W.J. Zou, K. Zhao, H.S. Zhang, X. Ren, Z. Yu, H. Robinson, Z.P. Liu, W.C. Xiong and L. Mei#, 2023 Metformin enhances excitatory synaptic transmission onto hippocampal CA1 pyramidal neurons, W.B. Chen, J. Chen, Z.Y. Liu, B. Luo, T. Zhou, and E.K. Fei#, 2020 Neogenin in amygdala for neuronal activity and information processing, X.D. Sun#, W.B. Chen, D. Sun, J. Huang, Y.Q. Li, J.X. Pan, Y.N. Wang, K. Zhao, Z.Q. Dong, H.S. Wang, L. Xiong, A.G. Xuan, S.T. Zhao, A. Pillai, W.C. Xiong# and L. Mei, 2018 Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice, H.S. Wang, F. Liu, W.B. Chen, X.D. Sun, W.P. Cui, Z.Q. Dong, K. Zhao, H.S. Zhang, H.W. Li, G.L. Xing, E.K. Fei, B.X. Pan, B.M. Li, W.C. Xiong and L. Mei#, 2018

Areas of Focus

Circuit and molecular mechanisms of anxiety disorders and depression
Role and mechanisms of extracellular matrix in the central nervous system
Role and mechanisms of glial cells in the pathogenesis of mental disorders

Publications

Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models, W.B. Chen*, B. Luo*, N.N. Gao*, H.W. Li, H.S. Wang, L. Li, W.P. Cui, L. Zhang, D. Sun, F. Liu, Z.Q. Dong, X. Ren, H.S. Zhang, H. B. Su, W.C. Xiong, and L. Mei#, 2021
A novel spinal neuron connection for heat sensation, H.S. Wang*, W.B. Chen*, Z.Q. Dong*, G.L. Xing, W.P. Cui, L.L. Yao, W.J. Zou, H. Robinson, Y.Y. Bian, Z.P. Liu, K. Zhao, B. Luo, N.N. Gao, H.S. Zhang, X. Ren, Z. Yu, J. Meixiong, W.C. Xiong and L. Mei#, 2022
CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of Cap-dependent translation, Z.Q. Dong*, W.B. Chen*, C. Chen, H.S. Wang, W.P. Cui, Z.B. Tan, H. Robinson, N.N. Gao, B. Luo, L. Zhang, K. Zhao, W.C. Xiong and L. Mei#, 2020
Rap1b but not Rap1a in the forebrain is required for learned fear, W.B. Chen*, H.Q. Pan*, Y. He, X.H. Wang, W.H. Zhang, and B.X. Pan#, 2020
DiGeorge syndrome critical region gene 2 (DGCR2), a schizophrenia risk gene, regulates dendritic spine development through cell adhesion, D.Y. Ren*, B. Luo*, P. Chen, L.L. Yu, M.T. Xiong, Z.Q. Fu, T. Zhou, W.B. Chen# and E.K. Fei#, 2023
LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity, D. Lin*, L.H. Li*, W.B. Chen*, J. Chen, D.Y. Ren, Z.H. Zheng, C.Q. Zhao, Y.Z. Zhong, B. Luo, H.Y. Jing, P. Chen, S.Q. Zou, X.S. Lai, T. Zhou, N. Ding, L. Li, B.X. Pan#, E.K. Fei#, 2023
The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons, H.S. Wang*, W.P. Cui*, W.B. Chen*, F. Liu, Z.Q. Dong, G.L. Xing, B. Luo, N.N. Gao, W.J. Zou, K. Zhao, H.S. Zhang, X. Ren, Z. Yu, H. Robinson, Z.P. Liu, W.C. Xiong and L. Mei#, 2023
Metformin enhances excitatory synaptic transmission onto hippocampal CA1 pyramidal neurons, W.B. Chen, J. Chen, Z.Y. Liu, B. Luo, T. Zhou, and E.K. Fei#, 2020
Neogenin in amygdala for neuronal activity and information processing, X.D. Sun*#, W.B. Chen*, D. Sun*, J. Huang, Y.Q. Li, J.X. Pan, Y.N. Wang, K. Zhao, Z.Q. Dong, H.S. Wang, L. Xiong, A.G. Xuan, S.T. Zhao, A. Pillai, W.C. Xiong# and L. Mei, 2018
Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice, H.S. Wang*, F. Liu*, W.B. Chen*, X.D. Sun, W.P. Cui, Z.Q. Dong, K. Zhao, H.S. Zhang, H.W. Li, G.L. Xing, E.K. Fei, B.X. Pan, B.M. Li, W.C. Xiong and L. Mei#, 2018

Anxiety Depression Circuit Molecular Extracellular Matrix Central Nervous System Glial Cells Pathogenesis Mental Disorders Mechanisms

Lin-Lin Bi - Wuhan University

Changrui Chen - Fudan University

Zhengyi Luo - Guangzhou Medical University

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