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Wenbing Chen
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Anxiety
Depression
Circuit
Molecular
Extracellular Matrix
Central Nervous System
Glial Cells
Pathogenesis
Mental Disorders
Mechanisms
Areas of Focus
- Circuit and molecular mechanisms of anxiety disorders and depression
- Role and mechanisms of extracellular matrix in the central nervous system
- Role and mechanisms of glial cells in the pathogenesis of mental disorders
Work Experience
- 2023-Present - Guangzhou Medical University - Professor and Research Group Leader
- 2020-2023 - Nanchang University - Postdoctoral Researcher
Academic Background & Achievements
- 2020 - PhD: Nanchang University
- 2016-2018 - Joint PhD Training: Augusta University/Case Western Reserve University
- Postdoctoral Research: Nanchang University (2020-2023)
Publications
- Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models, W.B. Chen*, B. Luo*, N.N. Gao*, H.W. Li, H.S. Wang, L. Li, W.P. Cui, L. Zhang, D. Sun, F. Liu, Z.Q. Dong, X. Ren, H.S. Zhang, H. B. Su, W.C. Xiong, and L. Mei#, 2021
- A novel spinal neuron connection for heat sensation, H.S. Wang*, W.B. Chen*, Z.Q. Dong*, G.L. Xing, W.P. Cui, L.L. Yao, W.J. Zou, H. Robinson, Y.Y. Bian, Z.P. Liu, K. Zhao, B. Luo, N.N. Gao, H.S. Zhang, X. Ren, Z. Yu, J. Meixiong, W.C. Xiong and L. Mei#, 2022
- CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of Cap-dependent translation, Z.Q. Dong*, W.B. Chen*, C. Chen, H.S. Wang, W.P. Cui, Z.B. Tan, H. Robinson, N.N. Gao, B. Luo, L. Zhang, K. Zhao, W.C. Xiong and L. Mei#, 2020
- Rap1b but not Rap1a in the forebrain is required for learned fear, W.B. Chen*, H.Q. Pan*, Y. He, X.H. Wang, W.H. Zhang, and B.X. Pan#, 2020
- DiGeorge syndrome critical region gene 2 (DGCR2), a schizophrenia risk gene, regulates dendritic spine development through cell adhesion, D.Y. Ren*, B. Luo*, P. Chen, L.L. Yu, M.T. Xiong, Z.Q. Fu, T. Zhou, W.B. Chen# and E.K. Fei#, 2023
- LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity, D. Lin*, L.H. Li*, W.B. Chen*, J. Chen, D.Y. Ren, Z.H. Zheng, C.Q. Zhao, Y.Z. Zhong, B. Luo, H.Y. Jing, P. Chen, S.Q. Zou, X.S. Lai, T. Zhou, N. Ding, L. Li, B.X. Pan#, E.K. Fei#, 2023
- The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons, H.S. Wang*, W.P. Cui*, W.B. Chen*, F. Liu, Z.Q. Dong, G.L. Xing, B. Luo, N.N. Gao, W.J. Zou, K. Zhao, H.S. Zhang, X. Ren, Z. Yu, H. Robinson, Z.P. Liu, W.C. Xiong and L. Mei#, 2023
- Metformin enhances excitatory synaptic transmission onto hippocampal CA1 pyramidal neurons, W.B. Chen, J. Chen, Z.Y. Liu, B. Luo, T. Zhou, and E.K. Fei#, 2020
- Neogenin in amygdala for neuronal activity and information processing, X.D. Sun*#, W.B. Chen*, D. Sun*, J. Huang, Y.Q. Li, J.X. Pan, Y.N. Wang, K. Zhao, Z.Q. Dong, H.S. Wang, L. Xiong, A.G. Xuan, S.T. Zhao, A. Pillai, W.C. Xiong# and L. Mei, 2018
- Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice, H.S. Wang*, F. Liu*, W.B. Chen*, X.D. Sun, W.P. Cui, Z.Q. Dong, K. Zhao, H.S. Zhang, H.W. Li, G.L. Xing, E.K. Fei, B.X. Pan, B.M. Li, W.C. Xiong and L. Mei#, 2018
Awards
- Nanshan Scholar Core Talent
- National Natural Science Foundation Youth Project
- China Postdoctoral Science Foundation First-Class Funding
