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Xinliang Mao
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Tumorigenesis
Targeted Therapy
Cancer
Oncology
Molecular Biology
Pharmacology
Pathophysiology
Cell Biology
Biochemistry
Genetics
Areas of Focus
- Tumorigenesis and Targeted Therapy
Academic Background & Achievements
- PhD: Peking University
- Guangzhou High-Level Talent Outstanding Expert, 2020
- Jiangsu Province Science and Technology Progress First Prize, 2016
- Higher Education Science and Technology Progress First Prize, 2016
- Jiangsu Medical Science and Technology Outstanding Youth, 2015
Publications
- Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma., Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Stewart AK, Moran MF, Wu D*, Mao X*., 2021
- The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice., Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi C, Du J, Hou J, Wang G, Wu D, Stewart A, Schimmer A, Moran M, Mao X*., 2016
- A small molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway., Mao X*, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, Maclean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD., 2011
- Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma., Mao X, Li X, Sprangers M, Wang X, Vengopal A, Wood T, Zhang Y, Kuntz D, Coe E, Stewart AK, Roase D, Batey RA, Kay LE, and Schimmer AD*., 2009
- Cyproheptadine displays preclinical activity in myeloma and leukemia., Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Zavareh RB, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD*., 2008
- A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin., Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey S, Gillis L, Barber DL, Wrana J, Ezzat S, and Schimmer AD*., 2007
- The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival., He Y, Wang S, Tong J, Jiang S, Yang Y, Zhang Z, Xu Y, Zeng Y*, Cao B*, Moran MF, Mao X*., 2020
- Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis., Liu Y, Xu X, Lin P, He Y, Zhang Y, Cao B, Zhang Z, Sethi G, Liu J, Zhou X*, Mao X*., 2019
- The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor., Du Y, Liu Y, Xu Y, Juan J, Zhang Z, Xu Z, Cao B, Wang Q, Zeng Y*, Mao X*., 2018
- The ring finger protein RNF6 induces leukemia cell proliferation as a direct target of pre-B-cell leukemia homeobox 1., Xu X, Han K, Tang X, Zeng Y, Lin X, Zhao Y, Zhang Z, Cao B, Wu D, Mao X*., 2016
Awards
- Guangzhou High-Level Talent Outstanding Expert, 2020
- Jiangsu Province Science and Technology Progress First Prize, 2016
- Higher Education Science and Technology Progress First Prize, 2016
- Jiangsu Medical Science and Technology Outstanding Youth, 2015
