Professor | Xinliang Mao | Asia Growth Partners

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Name	Xinliang Mao
Contact Information	xinliangmao@gzhmu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Xinliang Mao

Contact Information

xinliangmao@gzhmu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD: Peking University Guangzhou High-Level Talent Outstanding Expert, 2020 Jiangsu Province Science and Technology Progress First Prize, 2016 Higher Education Science and Technology Progress First Prize, 2016 Jiangsu Medical Science and Technology Outstanding Youth, 2015
Awards	Guangzhou High-Level Talent Outstanding Expert, 2020 Jiangsu Province Science and Technology Progress First Prize, 2016 Higher Education Science and Technology Progress First Prize, 2016 Jiangsu Medical Science and Technology Outstanding Youth, 2015

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD: Peking University
Guangzhou High-Level Talent Outstanding Expert, 2020
Jiangsu Province Science and Technology Progress First Prize, 2016
Higher Education Science and Technology Progress First Prize, 2016
Jiangsu Medical Science and Technology Outstanding Youth, 2015

Awards

Guangzhou High-Level Talent Outstanding Expert, 2020
Jiangsu Province Science and Technology Progress First Prize, 2016
Higher Education Science and Technology Progress First Prize, 2016
Jiangsu Medical Science and Technology Outstanding Youth, 2015

Areas of Focus	Tumorigenesis and Targeted Therapy
Publications	Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma., Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Stewart AK, Moran MF, Wu D, Mao X., 2021 The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice., Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi C, Du J, Hou J, Wang G, Wu D, Stewart A, Schimmer A, Moran M, Mao X., 2016 A small molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway., Mao X, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, Maclean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD., 2011 Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma., Mao X, Li X, Sprangers M, Wang X, Vengopal A, Wood T, Zhang Y, Kuntz D, Coe E, Stewart AK, Roase D, Batey RA, Kay LE, and Schimmer AD., 2009 Cyproheptadine displays preclinical activity in myeloma and leukemia., Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Zavareh RB, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD., 2008 A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin., Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey S, Gillis L, Barber DL, Wrana J, Ezzat S, and Schimmer AD., 2007 The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival., He Y, Wang S, Tong J, Jiang S, Yang Y, Zhang Z, Xu Y, Zeng Y, Cao B, Moran MF, Mao X., 2020 Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis., Liu Y, Xu X, Lin P, He Y, Zhang Y, Cao B, Zhang Z, Sethi G, Liu J, Zhou X, Mao X., 2019 The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor., Du Y, Liu Y, Xu Y, Juan J, Zhang Z, Xu Z, Cao B, Wang Q, Zeng Y, Mao X., 2018 The ring finger protein RNF6 induces leukemia cell proliferation as a direct target of pre-B-cell leukemia homeobox 1., Xu X, Han K, Tang X, Zeng Y, Lin X, Zhao Y, Zhang Z, Cao B, Wu D, Mao X*., 2016

Areas of Focus

Tumorigenesis and Targeted Therapy

Publications

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma., Xu Y, Xu M, Tong J, Tang X, Chen J, Chen X, Zhang Z, Cao B, Stewart AK, Moran MF, Wu D*, Mao X*., 2021
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice., Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi C, Du J, Hou J, Wang G, Wu D, Stewart A, Schimmer A, Moran M, Mao X*., 2016
A small molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway., Mao X*, Cao B, Wood TE, Hurren R, Tong J, Wang X, Wang W, Li J, Jin Y, Sun W, Spagnuolo PA, Maclean N, Moran MF, Datti A, Wrana J, Batey RA, Schimmer AD., 2011
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma., Mao X, Li X, Sprangers M, Wang X, Vengopal A, Wood T, Zhang Y, Kuntz D, Coe E, Stewart AK, Roase D, Batey RA, Kay LE, and Schimmer AD*., 2009
Cyproheptadine displays preclinical activity in myeloma and leukemia., Mao X, Liang SB, Hurren R, Gronda M, Chow S, Xu GW, Wang X, Zavareh RB, Jamal N, Messner H, Hedley DW, Datti A, Wrana JL, Zhu Y, Shi CX, Lee K, Tiedemann R, Trudel S, Stewart AK, Schimmer AD*., 2008
A chemical biology screen identifies glucocorticoids that regulate c-maf expression by increasing its proteasomal degradation through up-regulation of ubiquitin., Mao X, Stewart AK, Hurren R, Datti A, Zhu X, Zhu Y, Shi C, Lee K, Tiedemann R, Eberhard Y, Trudel S, Liang S, Corey S, Gillis L, Barber DL, Wrana J, Ezzat S, and Schimmer AD*., 2007
The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival., He Y, Wang S, Tong J, Jiang S, Yang Y, Zhang Z, Xu Y, Zeng Y*, Cao B*, Moran MF, Mao X*., 2020
Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis., Liu Y, Xu X, Lin P, He Y, Zhang Y, Cao B, Zhang Z, Sethi G, Liu J, Zhou X*, Mao X*., 2019
The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor., Du Y, Liu Y, Xu Y, Juan J, Zhang Z, Xu Z, Cao B, Wang Q, Zeng Y*, Mao X*., 2018
The ring finger protein RNF6 induces leukemia cell proliferation as a direct target of pre-B-cell leukemia homeobox 1., Xu X, Han K, Tang X, Zeng Y, Lin X, Zhao Y, Zhang Z, Cao B, Wu D, Mao X*., 2016

Tumorigenesis Targeted Therapy Cancer Oncology Molecular Biology Pharmacology Pathophysiology Cell Biology Biochemistry Genetics

Guoheng Xu - Peking University

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