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Aiguo Xuan
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Neurodevelopment
Cognitive Impairment
Epigenetics
Neuronal Regeneration
Neurodegeneration
Dna Methylation
Neural Stem Cells
Jak2/Stat3 Signaling
Metformin
Pparβ
Areas of Focus
- Relationship between neurodevelopmental abnormalities and cognitive impairment
- Epigenetic modifications and neuronal regeneration
- Neurodegenerative diseases
Academic Background & Achievements
- PhD: Southern Medical University
- Mentored by Academician Tianming Gao
- Guangdong Province Outstanding Young Teacher
- Guangzhou High-Level Talent
Publications
- JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation., Kong X, Gong Z, Zhang L, Sun X, Ou Z, Xu B, Huang J, Long D, He X, Lin X, Li Q, Xu L, Xuan A., 2019
- Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice., Ou Z, Kong X, Sun X, He X, Zhang L, Gong Z, Huang J, Xu B, Long D, Li J, Li Q, Xu L, Xuan A., 2018
- PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation., Ye X, Wu Y, Xu J, Liu H, Wang H, Li Q, Li Q, Xuan A., 2022
- Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice., Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A., 2019
- PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications., Zhang X, He X, Li Q, Kong X, Ou Z, Zhang L, Gong Z, Long D, Li J, Zhang M, Ji W, Zhang W, Xu L, Xuan A., 2017
- Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation., Zhang L, Li Q, Wang H, Wu Y, Ye X, Gong Z, Li Q, Xuan A., 2022
- Mettl3-mediated m6A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects., Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A., 2022
- Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula., Guan YF, Huang GB, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan A, Sun XD., 2020
- Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice., Lin XH, Ye XJ, Li QF, Gong Z, Cao X, Li JH, Zhao ST, Sun XD, He XS, Xuan AG., 2020
- Identification of candidate genes associated with clinical onset of Alzheimer's disease., Liao W, Luo H, Ruan Y, Mai Y, Liu C, Chen J, Yang S, Xuan A, Liu J., 2022
- Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice., Li Q, Wang X, Wang ZH, Lin Z, Yang J, Chen J, Wang R, Ye W, Li Y, Wu Y, Xuan A., 2022
