Professor | Aiguo Xuan | Asia Growth Partners

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Name	Aiguo Xuan
Contact Information	xag2005@163.com
Language ability	Chinese, English
Province	Guangdong

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Name

Aiguo Xuan

Contact Information

xag2005@163.com

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Guangzhou Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD: Southern Medical University Mentored by Academician Tianming Gao Guangdong Province Outstanding Young Teacher Guangzhou High-Level Talent

University/Lab Affiliation and Title

Guangzhou Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD: Southern Medical University
Mentored by Academician Tianming Gao
Guangdong Province Outstanding Young Teacher
Guangzhou High-Level Talent

Areas of Focus	Relationship between neurodevelopmental abnormalities and cognitive impairment Epigenetic modifications and neuronal regeneration Neurodegenerative diseases
Publications	JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation., Kong X, Gong Z, Zhang L, Sun X, Ou Z, Xu B, Huang J, Long D, He X, Lin X, Li Q, Xu L, Xuan A., 2019 Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice., Ou Z, Kong X, Sun X, He X, Zhang L, Gong Z, Huang J, Xu B, Long D, Li J, Li Q, Xu L, Xuan A., 2018 PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation., Ye X, Wu Y, Xu J, Liu H, Wang H, Li Q, Li Q, Xuan A., 2022 Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice., Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A., 2019 PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications., Zhang X, He X, Li Q, Kong X, Ou Z, Zhang L, Gong Z, Long D, Li J, Zhang M, Ji W, Zhang W, Xu L, Xuan A., 2017 Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation., Zhang L, Li Q, Wang H, Wu Y, Ye X, Gong Z, Li Q, Xuan A., 2022 Mettl3-mediated m6A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects., Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A., 2022 Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula., Guan YF, Huang GB, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan A, Sun XD., 2020 Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice., Lin XH, Ye XJ, Li QF, Gong Z, Cao X, Li JH, Zhao ST, Sun XD, He XS, Xuan AG., 2020 Identification of candidate genes associated with clinical onset of Alzheimer's disease., Liao W, Luo H, Ruan Y, Mai Y, Liu C, Chen J, Yang S, Xuan A, Liu J., 2022 Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice., Li Q, Wang X, Wang ZH, Lin Z, Yang J, Chen J, Wang R, Ye W, Li Y, Wu Y, Xuan A., 2022

Areas of Focus

Relationship between neurodevelopmental abnormalities and cognitive impairment
Epigenetic modifications and neuronal regeneration
Neurodegenerative diseases

Publications

JAK2/STAT3 signaling mediates IL-6-inhibited neurogenesis of neural stem cells through DNA demethylation/methylation., Kong X, Gong Z, Zhang L, Sun X, Ou Z, Xu B, Huang J, Long D, He X, Lin X, Li Q, Xu L, Xuan A., 2019
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice., Ou Z, Kong X, Sun X, He X, Zhang L, Gong Z, Huang J, Xu B, Long D, Li J, Li Q, Xu L, Xuan A., 2018
PPARβ mediates mangiferin-induced neuronal differentiation of neural stem cells through DNA demethylation., Ye X, Wu Y, Xu J, Liu H, Wang H, Li Q, Li Q, Xuan A., 2022
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice., Gong Z, Huang J, Xu B, Ou Z, Zhang L, Lin X, Ye X, Kong X, Long D, Sun X, He X, Xu L, Li Q, Xuan A., 2019
PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications., Zhang X, He X, Li Q, Kong X, Ou Z, Zhang L, Gong Z, Long D, Li J, Zhang M, Ji W, Zhang W, Xu L, Xuan A., 2017
Gadd45g, a novel antidepressant target, mediates metformin-induced neuronal differentiation of neural stem cells via DNA demethylation., Zhang L, Li Q, Wang H, Wu Y, Ye X, Gong Z, Li Q, Xuan A., 2022
Mettl3-mediated m6A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects., Xu B, Li Q, Wu Y, Wang H, Xu J, Liu H, Xuan A., 2022
Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula., Guan YF, Huang GB, Xu MD, Gao F, Lin S, Huang J, Wang J, Li YQ, Wu CH, Yao S, Wang Y, Zhang YL, Teoh JP, Xuan A, Sun XD., 2020
Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice., Lin XH, Ye XJ, Li QF, Gong Z, Cao X, Li JH, Zhao ST, Sun XD, He XS, Xuan AG., 2020
Identification of candidate genes associated with clinical onset of Alzheimer's disease., Liao W, Luo H, Ruan Y, Mai Y, Liu C, Chen J, Yang S, Xuan A, Liu J., 2022
Changes in dendritic complexity and spine morphology following BCG immunization in APP/PS1 mice., Li Q, Wang X, Wang ZH, Lin Z, Yang J, Chen J, Wang R, Ye W, Li Y, Wu Y, Xuan A., 2022

Neurodevelopment Cognitive Impairment Epigenetics Neuronal Regeneration Neurodegeneration Dna Methylation Neural Stem Cells Jak2/Stat3 Signaling Metformin Pparβ

He Guiqiong - Chongqing Medical University

He Guiqiong - Chongqing Medical University

Wei Hua Yu - Chongqing Medical University

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