Upload Avatar (500 x 500)
Yu Xia Zhang
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Chronic Diseases
Children
Immune Pathogenesis
Regional
Infection
Immunity
Immunodeficiency
Autoinflammation
Research
Pediatrics
Areas of Focus
- Regional immune pathogenesis of chronic diseases in children
- Infection immunity
- Immunodeficiency and autoinflammation
Work Experience
- 2007-2009 - University of Cambridge - Research on pediatric autoimmune diseases
- 2009-2016 - Walter & Eliza Hall Institute of Medical Research - Research on pediatric autoimmune diseases
- 2016-present - Return to China - Pearl River Scholar Distinguished Professor, Guangdong Province
Academic Background & Achievements
- 2007 - PhD: University of Chinese Academy of Sciences
- Achievement: Conducted research on the pathogenesis of pediatric autoimmune diseases at the University of Cambridge and Walter & Eliza Hall Institute of Medical Research
- Achievement: Received 4 national project grants from JDRF and NHMRC
- Achievement: Authorized 2 invention patents
- Achievement: Co-supervised 2 doctoral students
Publications
- Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia, Jun Wang, et al., 2020
- IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia, Lu, B., et al., 2020
- Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways, Huang, B., et al., 2019
- Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner, Zhang, Y., et al., 2018
- CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation, Rashidi, M., et al., 2018
- Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface, Moghaddas, F., et al., 2018
- The Development and Diversity of ILCs, NK Cells and Their Relevance in Health and Diseases, Zhang, Y. and B. Huang, 2017
- Life and Death of Activated T Cells: How Are They Different from Naive T Cells?, Zhan, Y., et al., 2017
- MicroRNAs in CD4(+) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes, Zhang, Y., et al., 2016
- Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic 'T(H)2-type' immunity associated with development of food allergy, Zhang, Y., et al., 2016
- Genome-wide DNA methylation analysis identifies hypomethylated genes regulated by FOXP3 in human regulatory T cells, Zhang, Y., et al., 2013
- T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10, Bandala-Sanchez, E., et al., 2013
- The polycomb repressive complex 2 governs life and death of peripheral T cells, Zhang, Y., et al., 2014
Awards
- 2016: Pearl River Scholar Distinguished Professor, Guangdong Province
- 2019: Recognized as one of the 'Top 10 Medical Advances in China'
