Professor | Sheng Han | Asia Growth Partners

Name	Sheng Han
Language ability	Chinese, English
Province	Shanghai

Name

Sheng Han

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai University
Faculty	Medicine
Academic Background & Achievements	2015-2019 PhD in Chemistry: Fudan University Doctoral supervisor: Fen-Er Chen, Academician Postdoctoral research at Shanghai Institute of Materia Medica, Chinese Academy of Sciences Hosted National Natural Science Foundation of China Young Scientist Fund Project and China Postdoctoral Science Foundation Project
Work Experience	2020-03 to 2022-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher 2022-12 to present - Shanghai University Medical School - Faculty Member

University/Lab Affiliation and Title

Shanghai University

Faculty

Medicine

Academic Background & Achievements

2015-2019 PhD in Chemistry: Fudan University
Doctoral supervisor: Fen-Er Chen, Academician
Postdoctoral research at Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Hosted National Natural Science Foundation of China Young Scientist Fund Project and China Postdoctoral Science Foundation Project

Work Experience

2020-03 to 2022-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
2022-12 to present - Shanghai University Medical School - Faculty Member

Areas of Focus	Development of small molecule antiviral drugs Discovery and anti-inflammatory activity of marine biofunctional molecules
Publications	Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Lei, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020 Fragment hopping-based discovery of novel sulfinylacetamide- diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020 Discovery of Potent Ebola Entry Inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide Scaffold, S. Han, H. Li, W. Chen, L. Yang, X. Tong, J. Zuo, Y. Hu, 2022 Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020 Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters, Z. Deng, S. Han, M. Ke, Y. Ning, F.E. Chen, 2022 Design of biphenyl‐substituted diarylpyrimidines with a cyanomethyl linker as HIV‐1 NNRTIs via a molecular hybridization strategy, Y. Lei, S. Han, C. Pannecouque, E. De Clercq, C. Zhuang, F. Chen, 2020 Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold, W. Chen, B. Feng, S. Han, P. Wang, W. Chen, Y. Zang, J. Li, Y. Hu, 2022

Areas of Focus

Development of small molecule antiviral drugs
Discovery and anti-inflammatory activity of marine biofunctional molecules

Publications

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Lei, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
Fragment hopping-based discovery of novel sulfinylacetamide- diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
Discovery of Potent Ebola Entry Inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide Scaffold, S. Han, H. Li, W. Chen, L. Yang, X. Tong, J. Zuo, Y. Hu, 2022
Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters, Z. Deng, S. Han, M. Ke, Y. Ning, F.E. Chen, 2022
Design of biphenyl‐substituted diarylpyrimidines with a cyanomethyl linker as HIV‐1 NNRTIs via a molecular hybridization strategy, Y. Lei, S. Han, C. Pannecouque, E. De Clercq, C. Zhuang, F. Chen, 2020
Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold, W. Chen, B. Feng, S. Han, P. Wang, W. Chen, Y. Zang, J. Li, Y. Hu, 2022

Antiviral Small Molecule Drug Development Hiv Ebola Sars-Cov-2 Enzyme Inhibitors Marine Biology Bioactivity Inflammation

Sheng Han - Shanghai University

Yiming Lu - Shanghai University

Yiming Lu - Shanghai University

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