Areas of Focus
- Development of small molecule antiviral drugs
- Discovery and anti-inflammatory activity of marine biofunctional molecules
Work Experience
- 2020-03 to 2022-06 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
- 2022-12 to present - Shanghai University Medical School - Faculty Member
Academic Background & Achievements
- 2015-2019 PhD in Chemistry: Fudan University
- Doctoral supervisor: Fen-Er Chen, Academician
- Postdoctoral research at Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- Hosted National Natural Science Foundation of China Young Scientist Fund Project and China Postdoctoral Science Foundation Project
Publications
- Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Lei, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
- Fragment hopping-based discovery of novel sulfinylacetamide- diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
- Discovery of Potent Ebola Entry Inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide Scaffold, S. Han, H. Li, W. Chen, L. Yang, X. Tong, J. Zuo, Y. Hu, 2022
- Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles, S. Han, Y. Sang, Y. Wu, Y. Tao, C. Pannecouque, E. De Clercq, C. Zhuang, F.-E. Chen, 2020
- Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters, Z. Deng, S. Han, M. Ke, Y. Ning, F.E. Chen, 2022
- Design of biphenyl‐substituted diarylpyrimidines with a cyanomethyl linker as HIV‐1 NNRTIs via a molecular hybridization strategy, Y. Lei, S. Han, C. Pannecouque, E. De Clercq, C. Zhuang, F. Chen, 2020
- Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold, W. Chen, B. Feng, S. Han, P. Wang, W. Chen, Y. Zang, J. Li, Y. Hu, 2022
