1999.9-2004.9 Doctorate: Boston University School of Medicine
Jiangsu Specially Appointed Professor
Published over 100 research papers with a cumulative impact factor exceeding 500
2004.10-2007.9 - Boston University School of Medicine - Postdoctoral Researcher
2007.10-present - Nanjing Medical University, Department of Pathophysiology - Professor
2015: First Prize in Natural Science by the Ministry of Education for 'Targeted Research on Key Nodes of Inflammation Regulation in Cardiovascular Diseases', ranked third
2019: Second Prize in Jiangsu Science and Technology Award for 'Epigenetic Research on Cardiovascular Diseases', ranked first
Research
Transcriptional Regulation in Major Diseases
Histone Methyltransferase SET1 Mediates Angiotensin II-Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice., Yu L, Yang G, Weng X, Liang P, Li L, Li J, Fan Z, Tian W, Wu X, Xu H, Fang M, Ji Y, Li Y, Chen Q, Xu Y*., 2015
A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy., Weng X, Yu L, Liang P, Li L, Dai X, Zhou B, Wu X, Xu H, Fang M, Chen Q, Xu Y*., 2015
Megakaryocytic leukemia 1 directs a histone H3 lysine 4 methyltransferase complex to regulate hypoxic pulmonary hypertension., Chen D, Yang Y, Cheng X, Fang F, Xu G, Yuan Z, Xia J, Kong H, Xie W, Wang H, Fang M, Gao Y, Xu Y*., 2015
Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy., Weng X, Yu L, Liang P, Chen D, Cheng X, Yang Y, Li L, Zhang T, Zhou B, Wu X, Xu H, Fang M, Gao Y, Chen Q, Xu Y*., 2015
Myocardin-Related Transcription Factor A Epigenetically Regulates Renal Fibrosis in Diabetic Nephropathy., Xu H, Wu X, Qin H, Tian W, Chen J, Sun L, Fang M, Xu Y*., 2015
Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells., Tian W, Hao C, Fan Z, Weng X, Qin H, Wu X, Fang M, Chen Q, Shen A, Xu Y*., 2015
HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells., Fang MM, Fan ZW, Tian WF, Zhao YH, Li P, Xu HH, Zhou BS, Zhang LP, Wu XY, Xu Y*., 2016
Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling., Tian WF, Fan ZW, Li JF, Hao CZ, Li M, Xu HH, Wu XY, Zhou BS, Zhang LP, Fang MM, Xu Y*., 2016
The arginine methyltransferase PRMT5 regulates CIITA-dependent MHC II transcription., Fan ZW, Kong XC, Xia J, Wu XY, Li H, Xu HH, Fang MM, Xu Y*., 2016
Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-β signaling., Zhou BS, Zeng S, Li LY, Fan ZW, Tian WF, Li M, Xu HH, Wu XY, Fang MM, Xu Y*., 2016
Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis., Sun LN, Fan ZW Chen JL, Tian WF, Li M, Xu HH, Wu XY, Shao J, Bian YY, Fang MM, Xu Y*., 2016
Protein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocyte by repressing SIRT1., Sun LN, Fan ZW, Chen JL, Tian WF, Li M, Xu HH, Wu XY, Fang MM, Xia J, Xu Y*., 2016
Protein inhibitor of activated STAT 4 (PIAS4) regulates liver fibrosis through modulating SMAD3 activity., Xu HH, Fan ZW, Tian WF, Xu Y*., 2016
HIC1 epigenetically represses CIITA transcription in B lymphocytes., Zeng S, Yang YY, Cheng X, Zhou BS, Li P, Zhao YH, Kong XC, Xu Y*., 2016
The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice., Fan Z, Li L, Li M, Zhang X, Hao C, Yu L, Zeng S, Xu H, Fang M, Shen A, Jenuwein T, Xu Y*., 2017
HIF-1α coordinates epigenetic activation of SIAH1 in hepatocytes in response to nutritional stress., Fan Z, Li Z, Yang Y, Liu S, Guo J, Xu Y*., 2017
MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response., Yu L, Fang F, Dai X, Xu H, Qi X, Fang M, Xu Y*., 2017
MKL is an epigenetic mediator of TNF-α-induced proinflammatory transcription in macrophages by interacting with ASH2., Song M, Fang F, Dai X, Yu L, Fang M, Xu Y*., 2017
SUV39H1 mediated SIRT1 trans-repression contributes to cardiac ischemia-reperfusion injury., Yang G, Zhang X, Weng X, Liang P, Dai X, Zeng S, Xu H, Huan H, Fang M, Li Y, Xu D, Xu Y*., 2017
Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury., Liming Y, Guang Y, Xinjian Z, Peng W, Xinyu W, Yuyu Y, Zilong L, Mingming F, Xu Y* ,Aijun S*, Junbo G*., 2018
Brg1 deficiency in vascular endothelial cells blocks neutrophil recruitment and ameliorates cardiac ischemia-reperfusion injury in mice., Zhang X, Liu S, Weng X, Zeng S, Yu L, Guo J, Xu Y*., 2018
Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells., Li Z, Chen B, Dong W, Xu W, Song M, Fang M, Guo J, Xu Y*., 2018
BRG1 regulates NOX gene transcription in endothelial cells and contributes to cardiac ischemia-reperfusion injury., Li Z, Zhang X, Liu S, Zeng S, Yu L, Yang G, Guo J, Xu Y*., 2018
Myocardin-related transcription factor A (MRTF-A) mediates doxorubicin-induced PERP transcription in colon cancer cells., Chen B, Li Z, Feng Y, Wu X, Xu Y*., 2018
The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte., Li N, Kong M, Zeng S, Xu Z, Li M, Hong W, Chu X, Sun X, Zhu M, Xu Y*., 2018
Angiotensin II induced CSF1 transcription is mediated by a crosstalk between different epigenetic factors in vascular endothelial cells., Shao J, Weng X, Zhuo L, Yu L, Li Z, Shen K, Xu W, Fang M, Xu Y*., 2018
Brahma related gene 1 (Brg1) contributes to liver regeneration by epigenetically activating the Wnt/β-catenin pathway in mice., Li N, Kong M, ZengS, Hao C, Li M, Li L, Xu Z, Zhu M, Xu Y*., 2019
BRG1 regulates endothelial-derived IL-33 to promote ischemia-reperfusion induced renal injury and fibrosis in mice., Liu L, Mao L, Wu X, Wu T, Liu W, Yang Y, Zhang T, Xu Y*., 2019
Area of Focus
Epigenetics | Gene Transcription | Regulation | Breast Cancer | Endometrial Cancer | Molecular Mechanisms | Cancer Development | Transcriptional Complexes | Gene Promoters | Therapeutic Targets
