1994-1997: PhD in Science from Nanjing Agricultural University
Selected for the New Century Excellent Talents Support Program by the Ministry of Education
Recipient of the Fok Ying Tung Young Teacher Fund
Second-tier training object of Jiangsu Province's '333 Project'
Young and middle-aged academic leader in Jiangsu Province's 'Qinglan Project'
Outstanding talent in the construction of Jiangsu Province's 'Six Talent Peaks'
Ninth Jiangsu Province Outstanding Youth Science and Technology Award
Supervisor of 'Jiangsu Province Excellent Doctoral Dissertation'
1997-2000: Lecturer at Nanjing Medical University
2000-2002: Postdoctoral Research at Loyola University Chicago, Department of Microbiology
2000-2005: Associate Professor at Nanjing Medical University
2005-present: Professor at Nanjing Medical University
2019/2018/2008: Supervisor of 'Jiangsu Province Excellent Doctoral Dissertation'
2008: Outstanding Talent in the Construction of Jiangsu Province's 'Six Talent Peaks'
2006: Ninth Jiangsu Province Outstanding Youth Science and Technology Award
2006: Selected for the New Century Excellent Talents Support Program by the Ministry of Education
2006: Recipient of the Fok Ying Tung Young Teacher Fund
2003: Second-tier training object of Jiangsu Province's '333 Project'
2003: Young and middle-aged academic leader in Jiangsu Province's 'Qinglan Project'
Research
Medical Virology Infection, Tumor, and Epigenetic Regulation
Lactylation of RNA m6A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus., Li W, Zhou J, Gu Y, Chen Y, Huang Y, Yang J, Zhu X, Zhao K, Yan Q, Zhao Z, Li X, Chen G, Jia X, Gao SJ, Lu C, 2024
Lactylation of NAT10 promotes N4-acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation., Yan Q, Zhou J, Gu Y, Huang W, Ruan M, Zhang H, Wang T, Wei P, Chen G, Li W, Lu C, 2024
KSHV vIL-6 promotes SIRT3-induced deacetylation of SERBP1 to inhibit ferroptosis and enhance cellular transformation by inducing lipoyltransferase 2 mRNA degradation., Zhou J, Wang T, Zhang H, Liu J, Wei P, Xu R, Yan Q, Chen G, Li W, Gao SJ, Lu C, 2024
NAT10-dependent N4-acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation., Yan Q, Zhou J, Wang Z, Ding X, Ma X, Li W, Jia X, Gao SJ, Lu C, 2023
Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)., Shi J, Jia X, He Y, Ma X, Qi X, Li W, Gao SJ, Yan Q, Lu C, 2023
A viral interferon regulatory factor degrades RNA-binding protein hnRNP Q1 to enhance aerobic glycolysis via recruiting E3 ubiquitin ligase KLHL3 and decaying GDPD1 mRNA., Qi X, Yan Q, Shang Y, Zhao R, Ding X, Gao SJ, Li W, Lu C, 2022
CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3., Yao S, Jia X, Wang F, Sheng L, Song P, Cao Y, Shi H, Fan W, Ding X, Gao SJ, Lu C, 2021
Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway., Li W, Wang F, Shi J, Feng Q, Chen Y, Qi X, Wang C, Lu H, Lu Z, Jia X, Yan Q, Gao SJ, Lu C, 2020
An oncogenic viral interferon regulatory factor upregulates CUB domain-containing protein 1 to promote angiogenesis by hijacking transcription factor lymphoid enhancer-binding factor 1 and metastasis suppressor CD82., Li W, Wang Q, Qi X, Guo Y, Lu H, Chen Y, Lu Z, Yan Q, Zhu X, Jung JU, Tosato G, Gao SJ, Lu C, 2020
Viral interleukin-6 encoded by an oncogenic virus promotes angiogenesis and cellular transformation by enhancing STAT3-mediated epigenetic silencing of caveolin 1., Li W, Wang Q, Qi X, Guo Y, Lu H, Chen Y, Lu Z, Yan Q, Zhu X, Jung JU, Tosato G, Gao SJ, Lu C, 2020
Suppression of the SAP18/HDAC1 complex by targeting TRIM56 and Nanog is essential for oncogenic viral FLICE-inhibitory protein-induced acetylation of p65/RelA, NF-κB activation, and promotion of cell invasion and angiogenesis., Ding X, Xu J, Wang C, Feng Q, Wang Q, Yang Y, Lu H, Wang F, Zhu K, Li W, Yan Q, Gao SJ, Lu C, 2019
Oncogenic KSHV-encoded interferon regulatory factor upregulates HMGB2 and CMPK1 expression to promote cell invasion by disrupting a complex lncRNA-OIP5-AS1/miR-218-5p network., Li W, Wang Q, Feng Q, Wang F, Yan Q, Gao SJ, Lu C, 2019
A DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer., Ding X, Jia X, Wang C, Xu J, Gao SJ, Lu C, 2019
Upregulation of miR-711 mediates HIV-1 Vpr promotion of KSHV latency and induction of pro-proliferative/survival cytokines by targeting the Notch/NF-κB signaling axis., Yan Q, Zhao R, Shen C, Wang F, Li W, Gao SJ, Lu C, 2018
A viral microRNA downregulates metastasis suppressor CD82 and induces cell invasion and angiogenesis by activating the c-Met signaling., Li W, Hu M, Wang C, Lu H, Chen F, Xu J, Shang Y, Wang F, Qin J, Yan Q, Krueger B J, Renne R, Gao SJ, Lu C, 2017
KSHV microRNAs: Tricks of the devil., Qin J, Li W, Gao SJ, Lu C, 2017
HIV-1 Vpr inhibits Kaposi's sarcoma-associated herpesvirus lytic replication by inducing miR-942-5p and activating NF-κB signaling., Yan Q, Shen C, Qin J, Li W, Hu M, Lu H, Qin D, Zhu J, Gao SJ, Lu C, 2016
The SH3BGR/STAT3 pathway regulates cell migration and angiogenesis induced by a gammaherpesvirus microRNA., Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C, 2016
MiRNA-891a-5p mediates HIV-1 Tat and KSHV Orf-K1 synergistic induction of angiogenesis by activating NF-κB signaling., Yao S, Hu M, Hao T, Li W, Xue X, Xue M, Zhu X, Zhou F, Qin D, Yan Q, Zhu J, Gao SJ, Lu C, 2015
A KSHV microRNA directly targets G protein-coupled receptor kinase 2 to promote the migration and invasion of endothelial cells by inducing CXCR2 and activating AKT signaling., Hu M, Wang C, Li W, Lu W, Bai Z, Qin D, Yan Q, Zhu J, Krueger BJ, Renne R, Gao SJ, Lu C, 2015
HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway., Xue M, Yao S, Hu M, Li W, Hao T, Zhou F, Zhu X, Lu H, Qin D, Yan Q, Zhu J, Gao SJ, Lu C, 2014
Synergy between Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6 and HIV-1 Nef in promotion of angiogenesis and oncogenesis: role of the AKT signaling pathway., Zhu X, Guo Y, Yao S, Yan Q, Xue M, Hao T, Zhou F, Zhu J, Qin D, Lu C, 2014
Inhibition of Kaposi’s sarcoma-associated herpesvirus lytic replication by HIV-1 Nef and cellular microRNA hsa-miR-1258., Yan Q, Ma X, Shen C, Cao X, Feng N, Qin D, Zeng Y, Zhu J, Gao S, Lu C, 2014
Genomewide mapping and screening of Kaposi's sarcoma-associated herpesvirus (KSHV) 3'untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs., Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C, Gao SJ, 2014
Area of Focus
Epigenetics | Gene Transcription | Regulation | Breast Cancer | Endometrial Cancer | Molecular Mechanisms | Cancer Development | Transcriptional Complexes | Gene Promoters | Therapeutic Targets
