Professor | Yifan Dai | Asia Growth Partners

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Name	Yifan Dai
Contact Information	daiyifan@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

Upload Avatar (500 x 500)

Name

Yifan Dai

Contact Information

daiyifan@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1989-1991: Lecturer at Fudan University 1991-1995: Postdoctoral Researcher at Salk Institute, USA 2012: Leader of 'Jiangsu Science and Technology Innovation Team' 2012: Recipient of Jiangsu Province 'May 1st Labor Honor Medal'
Work Experience	1989-1991 - Fudan University - Lecturer 1991-1995 - Salk Institute, USA - Postdoctoral Researcher 1995-1998 - Gene Therapy Unit, Baxter Healthcare Corp., USA - Researcher 1998-2004 - Revivicor Inc, USA - Senior Researcher, Director of Molecular Biology Laboratory 2004-2008 - University of Pittsburgh School of Medicine, USA - Associate Professor at Starzl Transplantation Institute 2009-2012 - University of Pittsburgh School of Medicine, USA - Adjunct Associate Professor 2009-present - Nanjing Medical University - Distinguished Professor
Awards	2010: Zijin Talent 2011: Jiangsu Province 'Double Innovation Talent' 2011: Jiangsu Province 'May 1st Labor Honor Medal' 2018: Tianyuan Scholar

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1989-1991: Lecturer at Fudan University
1991-1995: Postdoctoral Researcher at Salk Institute, USA
2012: Leader of 'Jiangsu Science and Technology Innovation Team'
2012: Recipient of Jiangsu Province 'May 1st Labor Honor Medal'

Work Experience

1989-1991 - Fudan University - Lecturer
1991-1995 - Salk Institute, USA - Postdoctoral Researcher
1995-1998 - Gene Therapy Unit, Baxter Healthcare Corp., USA - Researcher
1998-2004 - Revivicor Inc, USA - Senior Researcher, Director of Molecular Biology Laboratory
2004-2008 - University of Pittsburgh School of Medicine, USA - Associate Professor at Starzl Transplantation Institute
2009-2012 - University of Pittsburgh School of Medicine, USA - Adjunct Associate Professor
2009-present - Nanjing Medical University - Distinguished Professor

Awards

2010: Zijin Talent
2011: Jiangsu Province 'Double Innovation Talent'
2011: Jiangsu Province 'May 1st Labor Honor Medal'
2018: Tianyuan Scholar

Areas of Focus	Xenotransplantation Gene Editing and Disease Animal Models
Publications	Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis., Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF, Bai XC, 2013 Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice., Chen TY, Zhang ZM, Zheng XC, Wang L, Huang MJ, Qin S, Chen J, Lai PL, Yang CL, Liu J, Dai YF, Jin DD, Bai XC, 2013 mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo., Zhang Y, Xu S, Lin J, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X, 2012 Transgenic overproduction of omega-3 polyunsaturated fatty acids provides neuroprotection and enhances endogenous neurogenesis after stroke., Hu X, Zhang F, Leak RK, Zhang W, Iwai M, Stetler RA, Dai Y, Zhao A, Gao Y, Chen J, 2013 Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T cell immune response and immune status., Hara H, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Copper DK, Dai Y, Starzl TE, 2013 Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice., Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC, 2014 mTORC1/2 targeted by n-3 polyunsaturated fatty acids (PUFAs) in the prevention of mammary tumorigenesis and tumor progression., Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Gao T, Zhao A, Dai Y, Bai X, 2014 Unbalanced omega-6/omega-3 ratio in the red meat products in China., Ming Yu, Qianqian Gao, Yan Wang, Wei Zhang, Lin Li, Ying Wang, Yifan Dai, 2013 Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids in preclinical models., Zheng H, Tang H, Liu M, He M, Lai P, Dong H, Lin J, Jia C, Zhong M, Dai Y, Bai X, Wang L, 2014 Endogenous ω-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice., Li J, Li FR, Wei D, Jia W, Kang JX, Stefanovic-Racic M, Dai Y, Zhao AZ, 2014 Genome-wide screen for serum microRNA expression profile in mfat-1 transgenic mice., Gao Z, Wang Y, Ren Z, Li Q, Wang Y, Dai Y, 2014 Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs., Cheng J, Wang Y, Zhang Z, Jin Y, Li Q, Want R, Wang Y, Li X, Xiong Q, Zhang M, Li R, Dai Y, 2015 Generation of B cell-deficient pigs by highly efficient CRISPR/Cas9-mediated gene targeting., Chen F, Wang Y, Yuan Y, Zhang W, Ren Z, Jin Y, Liu X, Xiong Q, Chen Q, Zhang M, Li X, Zhao L, Li Z, Wu Z, Zhang Y, Hu F, Huang J, Li R, Dai Y, 2015 Endothelin-1-induced mini-stroke in the dorsal hippocampus or lateral amygdala results in deficits in learning and memory., Sheng T, Zhang X, Wang S, Zhang J, Lu W, Dai Y, 2015 Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs., Iwase H, Ekser B, Satyananda V, Zhou H, Hara H, Bajona P, Wijkstrom M, Bhama JK, Long C, Veroux M, Wang Y, Dai Y, Phelps C, Ayares D, Ezzelarab MB, Cooper DK, 2015 Generation of monoclonal antibodies against n-3 fatty acid desaturase., Zhang Y, Yuan Y, Sheng M, Zhang W, Wang Y, Zhang X, Yifan Dai, 2015 Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos., Hou DR, Jin Y, Nie XW, Zhang ML, Ta N, Zhao LH, Yang N, Chen Y, Wu ZQ, Jiang HB, Li YR, Sun QY, Dai YF, Li RF, 2016 Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation., Zhou M, Hara H, Dai Y, Mou L, Cooper DK, Wu C, Cai Z, 2016 Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys., Dong X, Hara H, Wang Y, Wang L, Zhang Y, Cooper DK, Dai Y, Pan Z, 2017 Klotho attenuated antibody-mediated porcine endothelial cell activation and injury., Liu L, Gao H, Hong C, He C, Pan D, Dai Y, Hara H, Cooper DK, Li Z, Cai Z, Mou L, 2017 Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning., Gao H, Zhao C, Xiang X, Li Y, Zhao Y, Li Z, Pan D, Dai Y, Hara H, Cooper DK, Cai Z, Mou L, 2017 Enhancement of porcine intramuscular fat content by overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase in skeletal muscle., Zijian Ren, Ying Wang, Yuanyuan Ren, Zhengwei Zhang, Weiwang Gu, Zhaoting Wu, Lingyi Chen, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai, 2017 Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression., Zhifeng Zeng, Haiyuan Yang, Ying Wang, Jiafa Ren, Yifan Dai, Chunsun Dai, 2017 ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity., Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X, Zhao AZ, 2017 Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation., Chen P, Gao H, Lu Y, Nie H, Liu Z, Zhao Y, Fan N, Zou Q, Dai Y, Tang A, Hara H, Cai Z, Cooper DKC, Lai L, Mou L, 2017 Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting., Zhang W, Wang G, Wang Y, Jin Y, Zhao L, Xiong Q, Zhang L, Mou L, Li R, Yang H, Dai Y, 2017 Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting., Ze Li, Hai-Yuan Yang, Ying Wang, Man-Ling Zhang, Xiao-Rui Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Li-Sha Mou, Yan Liu, Rong-Feng Li, Yi Rao, Yi-Fan Dai, 2017 DNA demethylation pattern of in-vitro fertilized and cloned porcine pronuclear stage embryos., Xiaowei Nie, Qiang Liu, Ronggen Wang, Wenjie Sheng, Xiaokang Li, Manling Zhang, Yong Jin, Lihua Zhao, Daorong Hou, Ning Yang, Zhaoqiang Wu, Yifan Dai, Rongfeng Li, 2017 Identification of novel diagnostic biomarkers for thyroid carcinoma., Wang X, Zhang Q, Cai Z, Dai Y, Mou L, 2017 Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model., Zhang J, Xie C, Lu Y, Zhou M, Qu Z, Yao D, Qiu C, Xu J, Pan D, Dai Y, Hara H, Cooper DKC, Ma S, Li M, Cai Z, Mou L, 2017 mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways., Yu J, Yang H, Fang B, Zhang Z, Wang Y, Dai Y, 2018 Derivation of novel naive-like porcine embryonic stem cells by a reprogramming factor-assisted strategy., Zhang M, Wang C, Jiang H, Liu M, Yang N, Zhao L, Hou D, Jin Y, Chen Q, Chen Y, Wang J, Dai Y, Li R, 2019 Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting., Wang J, Liu M, Zhao L, Li Y, Zhang M, Jin Y, Xiong Q, Liu X, Zhang L, Jiang H, Chen Q, Wang C, You Z, Yang H, Cao C, Dai Y, Li R, 2019 Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs., Chen Q, Fang B, Wang Y, Li C, Li X, Wang R, Xiong Q, Zhang L, Jin Y, Zhang M, Liu X, Li L, Mou L, Li R, Yang H, Dai Y, 2018 Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH., Zhang R, Wang Y, Chen L, Wang R, Li C, Li X, Fang B, Ren X, Ruan M, Liu J, Xiong Q, Zhang L, Jin Y, Zhang M, Liu X, Li L, Chen Q, Pan D, Li R, Cooper DKC, Yang H, Dai Y, 2018 Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs., Fang B, Ren X, Wang Y, Li Z, Zhao L, Zhang M, Li C, Zhang Z, Chen L, Li X, Liu J, Xiong Q, Zhang L, Jin Y, Liu X, Li L, Wei H, Yang H, Li R, Dai Y, 2018 OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X, Dai Y, 2019 The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation., Cooper DK, Hara H, Ezzelarab M, Bottino R, Trucco M, Phelps C, Ayares D, Dai Y, 2013 Potential alternative approaches to xenotransplantation., Mou L, Chen F, Dai Y, Cai Z, Cooper DK, 2015 The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs., Feng W, Dai Y, Mou L, Cooper DK, Shi D, Cai Z, 2015 Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future., Liu Z, Hu W, He T, Dai Y, Hara H, Bottino R, Cooper DK, Cai Z, Mou L, 2017 The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation., Zhao C, Cooper DKC, Dai Y, Hara H, Cai Z, Mou L*, 2018

Areas of Focus

Xenotransplantation
Gene Editing and Disease Animal Models

Publications

Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis., Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF*, Bai XC*, 2013
Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice., Chen TY, Zhang ZM, Zheng XC, Wang L, Huang MJ, Qin S, Chen J, Lai PL, Yang CL, Liu J, Dai YF, Jin DD, Bai XC*, 2013
mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo., Zhang Y, Xu S, Lin J, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X*, 2012
Transgenic overproduction of omega-3 polyunsaturated fatty acids provides neuroprotection and enhances endogenous neurogenesis after stroke., Hu X, Zhang F, Leak RK, Zhang W, Iwai M, Stetler RA, Dai Y, Zhao A, Gao Y, Chen J*, 2013
Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T cell immune response and immune status., Hara H*, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Copper DK, Dai Y*, Starzl TE, 2013
Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice., Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*, 2014
mTORC1/2 targeted by n-3 polyunsaturated fatty acids (PUFAs) in the prevention of mammary tumorigenesis and tumor progression., Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Gao T, Zhao A, Dai Y*, Bai X*, 2014
Unbalanced omega-6/omega-3 ratio in the red meat products in China., Ming Yu, Qianqian Gao, Yan Wang, Wei Zhang, Lin Li, Ying Wang*, Yifan Dai*, 2013
Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids in preclinical models., Zheng H, Tang H, Liu M, He M, Lai P, Dong H, Lin J, Jia C, Zhong M, Dai Y, Bai X, Wang L*, 2014
Endogenous ω-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice., Li J, Li FR, Wei D, Jia W, Kang JX, Stefanovic-Racic M, Dai Y*, Zhao AZ*, 2014
Genome-wide screen for serum microRNA expression profile in mfat-1 transgenic mice., Gao Z, Wang Y, Ren Z, Li Q, Wang Y*, Dai Y*, 2014
Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs., Cheng J, Wang Y, Zhang Z, Jin Y, Li Q, Want R, Wang Y, Li X, Xiong Q, Zhang M, Li R*, Dai Y*, 2015
Generation of B cell-deficient pigs by highly efficient CRISPR/Cas9-mediated gene targeting., Chen F, Wang Y, Yuan Y, Zhang W, Ren Z, Jin Y, Liu X, Xiong Q, Chen Q, Zhang M, Li X, Zhao L, Li Z, Wu Z, Zhang Y, Hu F, Huang J, Li R*, Dai Y*, 2015
Endothelin-1-induced mini-stroke in the dorsal hippocampus or lateral amygdala results in deficits in learning and memory., Sheng T, Zhang X, Wang S, Zhang J, Lu W*, Dai Y*, 2015
Initial in vivo experience of pig artery patch transplantation in baboons using mutant MHC (CIITA-DN) pigs., Iwase H, Ekser B, Satyananda V, Zhou H, Hara H, Bajona P, Wijkstrom M, Bhama JK, Long C, Veroux M, Wang Y, Dai Y, Phelps C, Ayares D, Ezzelarab MB, Cooper DK*, 2015
Generation of monoclonal antibodies against n-3 fatty acid desaturase., Zhang Y, Yuan Y, Sheng M, Zhang W, Wang Y, Zhang X*, Yifan Dai*, 2015
Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos., Hou DR, Jin Y, Nie XW, Zhang ML, Ta N, Zhao LH, Yang N, Chen Y, Wu ZQ, Jiang HB, Li YR, Sun QY, Dai YF, Li RF*, 2016
Circulating Organ-Specific MicroRNAs Serve as Biomarkers in Organ-Specific Diseases: Implications for Organ Allo- and Xeno-Transplantation., Zhou M, Hara H, Dai Y, Mou L, Cooper DK, Wu C, Cai Z*, 2016
Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys., Dong X, Hara H, Wang Y, Wang L, Zhang Y, Cooper DK, Dai Y*, Pan Z*, 2017
Klotho attenuated antibody-mediated porcine endothelial cell activation and injury., Liu L, Gao H, Hong C, He C, Pan D, Dai Y, Hara H, Cooper DK, Li Z, Cai Z, Mou L*, 2017
Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning., Gao H, Zhao C, Xiang X, Li Y, Zhao Y, Li Z, Pan D, Dai Y, Hara H, Cooper DK, Cai Z, Mou L*, 2017
Enhancement of porcine intramuscular fat content by overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase in skeletal muscle., Zijian Ren, Ying Wang, Yuanyuan Ren, Zhengwei Zhang, Weiwang Gu, Zhaoting Wu, Lingyi Chen, Lisha Mou, Rongfeng Li, Haiyuan Yang*, Yifan Dai*, 2017
Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression., Zhifeng Zeng, Haiyuan Yang, Ying Wang, Jiafa Ren, Yifan Dai*, Chunsun Dai*, 2017
ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity., Bi X, Li F, Liu S, Jin Y, Zhang X, Yang T, Dai Y, Li X*, Zhao AZ*, 2017
Altered expression of eNOS, prostacyclin synthase, prostaglandin G/H synthase, and thromboxane synthase in porcine aortic endothelial cells after exposure to human serum-relevance to xenotransplantation., Chen P, Gao H, Lu Y, Nie H, Liu Z, Zhao Y, Fan N, Zou Q, Dai Y, Tang A, Hara H, Cai Z, Cooper DKC, Lai L, Mou L*, 2017
Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting., Zhang W, Wang G, Wang Y, Jin Y, Zhao L, Xiong Q, Zhang L, Mou L, Li R, Yang H*, Dai Y*, 2017
Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting., Ze Li, Hai-Yuan Yang, Ying Wang, Man-Ling Zhang, Xiao-Rui Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Li-Sha Mou, Yan Liu, Rong-Feng Li*, Yi Rao*, Yi-Fan Dai*, 2017
DNA demethylation pattern of in-vitro fertilized and cloned porcine pronuclear stage embryos., Xiaowei Nie, Qiang Liu, Ronggen Wang, Wenjie Sheng, Xiaokang Li, Manling Zhang, Yong Jin, Lihua Zhao, Daorong Hou, Ning Yang, Zhaoqiang Wu, Yifan Dai*, Rongfeng Li*, 2017
Identification of novel diagnostic biomarkers for thyroid carcinoma., Wang X, Zhang Q, Cai Z, Dai Y, Mou L*, 2017
Potential Antigens Involved in Delayed Xenograft Rejection in a Ggta1/Cmah Dko Pig-to-Monkey Model., Zhang J, Xie C, Lu Y, Zhou M, Qu Z, Yao D, Qiu C, Xu J, Pan D, Dai Y, Hara H, Cooper DKC, Ma S, Li M, Cai Z, Mou L*, 2017
mfat-1 transgene protects cultured adult neural stem cells against cobalt chloride-mediated hypoxic injury by activating Nrf2/ARE pathways., Yu J, Yang H, Fang B, Zhang Z, Wang Y*, Dai Y*, 2018
Derivation of novel naive-like porcine embryonic stem cells by a reprogramming factor-assisted strategy., Zhang M, Wang C, Jiang H, Liu M, Yang N, Zhao L, Hou D, Jin Y, Chen Q, Chen Y, Wang J, Dai Y*, Li R*, 2019
Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting., Wang J, Liu M, Zhao L, Li Y, Zhang M, Jin Y, Xiong Q, Liu X, Zhang L, Jiang H, Chen Q, Wang C, You Z, Yang H, Cao C, Dai Y, Li R*, 2019
Overexpressing dominant-negative FGFR2-IIIb impedes lung branching morphogenesis in pigs., Chen Q, Fang B, Wang Y, Li C, Li X, Wang R, Xiong Q, Zhang L, Jin Y, Zhang M, Liu X, Li L, Mou L, Li R, Yang H*, Dai Y*, 2018
Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH., Zhang R, Wang Y, Chen L, Wang R, Li C, Li X, Fang B, Ren X, Ruan M, Liu J, Xiong Q, Zhang L, Jin Y, Zhang M, Liu X, Li L, Chen Q, Pan D, Li R, Cooper DKC, Yang H*, Dai Y*, 2018
Apolipoprotein E deficiency accelerates atherosclerosis development in miniature pigs., Fang B, Ren X, Wang Y, Li Z, Zhao L, Zhang M, Li C, Zhang Z, Chen L, Li X, Liu J, Xiong Q, Zhang L, Jin Y, Liu X, Li L, Wei H, Yang H*, Li R*, Dai Y*, 2018
OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia., Yao J, Zeng H, Zhang M, Wei Q, Wang Y, Yang H, Lu Y, Li R, Xiong Q, Zhang L, Chen Z, Xing G, Cao X*, Dai Y*, 2019
The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantation., Cooper DK*, Hara H, Ezzelarab M, Bottino R, Trucco M, Phelps C, Ayares D, Dai Y, 2013
Potential alternative approaches to xenotransplantation., Mou L, Chen F, Dai Y, Cai Z, Cooper DK*, 2015
The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs., Feng W, Dai Y, Mou L, Cooper DK, Shi D, Cai Z*, 2015
Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future., Liu Z, Hu W, He T, Dai Y, Hara H, Bottino R, Cooper DK, Cai Z, Mou L*, 2017
The Sda and Cad glycan antigens and their glycosyltransferase, β1,4GalNAcT-II, in xenotransplantation., Zhao C, Cooper DKC, Dai Y, Hara H, Cai Z, Mou L*, 2018

Xenotransplantation Gene Editing Disease Models Crispr/Cas9 Transgenic Pigs Organ Transplantation Biomedical Research Genetic Engineering Animal Models Regenerative Medicine

Lu Jing - Capital Medical University

Bai'An Chen - Capital Medical University

Fan Lin - Nanjing Medical University

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