Professor | Shen Yue | Asia Growth Partners

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Name	Shen Yue
Contact Information	yueshen@njmu.edu.cn
Language ability	Chinese, English
Province	Jiangsu

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Name

Shen Yue

Contact Information

yueshen@njmu.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1998.09-2003.07 Bachelor's in Clinical Medicine: Nanjing Medical University 2003.09-2006.07 Master's in Pathology and Pathophysiology: Nanjing Medical University 2012 PhD in Pathology and Pathophysiology: Nanjing Medical University Hosted National Natural Science Foundation projects and Jiangsu Natural Science Foundation projects Published research in international journals like Elife, Oncogene, J Biol Chem, Cell & Bioscience Granted 3 national invention patents
Work Experience	2006.09-2009.08 - Nanjing Medical University - Assistant Lecturer in Pathology and Pathophysiology 2009.09-2015.08 - Nanjing Medical University - Lecturer in Developmental Genetics 2015.09-present - Nanjing Medical University - Associate Professor in Developmental Genetics (renamed to Medical Genetics in 2018) 2016.02-2016.08 - Yale University - Visiting Scholar in the Department of Genetics 2018.11-present - Nanjing Medical University - Deputy Director of the Department of Medical Genetics
Awards	2022: Third Prize in National College Student Computer Design Competition, Instructor 2022: Second Prize in National College Student Life Science Competition, Instructor 2020: Zhao Xibao Young Teacher Award, Nanjing Medical University 2019: Course Leader for Jiangsu Province's English Quality Course for International Students 'Medical Genetics' 2019: Second Prize in National College Student Computer Design Competition, Provincial Special Prize, Instructor 2019: Course Leader for Jiangsu Province's Adult Higher Education Quality Resource Sharing Course 'Medical Genetics' 2018: Second Prize/Teaching Design Award in National University (Medical) Micro-lecture Teaching Competition

University/Lab Affiliation and Title

Nanjing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1998.09-2003.07 Bachelor's in Clinical Medicine: Nanjing Medical University
2003.09-2006.07 Master's in Pathology and Pathophysiology: Nanjing Medical University
2012 PhD in Pathology and Pathophysiology: Nanjing Medical University
Hosted National Natural Science Foundation projects and Jiangsu Natural Science Foundation projects
Published research in international journals like Elife, Oncogene, J Biol Chem, Cell & Bioscience
Granted 3 national invention patents

Work Experience

2006.09-2009.08 - Nanjing Medical University - Assistant Lecturer in Pathology and Pathophysiology
2009.09-2015.08 - Nanjing Medical University - Lecturer in Developmental Genetics
2015.09-present - Nanjing Medical University - Associate Professor in Developmental Genetics (renamed to Medical Genetics in 2018)
2016.02-2016.08 - Yale University - Visiting Scholar in the Department of Genetics
2018.11-present - Nanjing Medical University - Deputy Director of the Department of Medical Genetics

Awards

2022: Third Prize in National College Student Computer Design Competition, Instructor
2022: Second Prize in National College Student Life Science Competition, Instructor
2020: Zhao Xibao Young Teacher Award, Nanjing Medical University
2019: Course Leader for Jiangsu Province's English Quality Course for International Students 'Medical Genetics'
2019: Second Prize in National College Student Computer Design Competition, Provincial Special Prize, Instructor
2019: Course Leader for Jiangsu Province's Adult Higher Education Quality Resource Sharing Course 'Medical Genetics'
2018: Second Prize/Teaching Design Award in National University (Medical) Micro-lecture Teaching Competition

Areas of Focus	Molecular regulation mechanisms of tumor cells Pathogenesis of pediatric medulloblastoma, focusing on post-translational modification of proteins and intracellular signal transduction
Publications	Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas., Pu X, Ye Q, Cai J, Yang X, Fu Y, Fan X, Wu H, Chen J, Qiu Y, Yue S, 2021 Macro-autophagy supports Sonic Hedgehog signaling by promoting Patched1 degradation., Yang X, Jin N, Wang Y, Yao Y, Wang Y, Li T, Liu C, Yu T, Yin H, Zhang Z, Cheng SY, Yue S, 2021 Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development., Yu TT, Xu QF, Li SY, Huang HJ, Dugan S, Shao L, Roggenbuck JA, Liu XT, Liu HZ, Hirsch BA, Yue S, Liu C, Cheng SY, 2021 SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway., Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, Cai J, Cao Q, Xu Y, Gao B, Cheng SY, Yue S, Liu C, 2021 Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused., Liao H, Cai J, Liu C, Shen L, Pu X, Yao Y, Han B, Yu T, Cheng SY, Yue S, 2020 C-MET in intrahepatic cholangiocarcinoma: High-Frequency amplification predicts protein expression and a unique molecular subtype., Pu XH, Yue S, Wu HY, Yang J, Fan XS, Fu Y, Ye Q, Chen J, 2020 Sonic Hedgehog stimulates migration of MCF-7 breast cancer cells through Rac1., Shen T, Han B, Leng Y, Yan S, Shi JF, Yue S, Cheng SY, 2019 Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling., Liu X, Shen Q, Yu T, Huang H, Zhang Z, Ding J, Tang Y, Xu N, Yue S, 2016 Requirement of Smurf-mediated Endocytosis of Patched1 in Sonic Hedgehog Signal Reception., Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY, 2014 Dual phosphorylation of Suppressor of fused by PKA and GSK3beta regulates its stability and localization in the primary cilium., Chen Y, Yue S, Xie L, Pu XH, Jin T, Cheng SY, 2011 Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway., Yue S, Chen Y, Cheng SY, 2009

Areas of Focus

Molecular regulation mechanisms of tumor cells
Pathogenesis of pediatric medulloblastoma, focusing on post-translational modification of proteins and intracellular signal transduction

Publications

Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas., Pu X, Ye Q, Cai J, Yang X, Fu Y, Fan X, Wu H, Chen J, Qiu Y, Yue S, 2021
Macro-autophagy supports Sonic Hedgehog signaling by promoting Patched1 degradation., Yang X, Jin N, Wang Y, Yao Y, Wang Y, Li T, Liu C, Yu T, Yin H, Zhang Z, Cheng SY, Yue S, 2021
Deletion at an 1q24 locus reveals a critical role of long noncoding RNA DNM3OS in skeletal development., Yu TT, Xu QF, Li SY, Huang HJ, Dugan S, Shao L, Roggenbuck JA, Liu XT, Liu HZ, Hirsch BA, Yue S, Liu C, Cheng SY, 2021
SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway., Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, Cai J, Cao Q, Xu Y, Gao B, Cheng SY, Yue S, Liu C, 2021
Protein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused., Liao H, Cai J, Liu C, Shen L, Pu X, Yao Y, Han B, Yu T, Cheng SY, Yue S, 2020
C-MET in intrahepatic cholangiocarcinoma: High-Frequency amplification predicts protein expression and a unique molecular subtype., Pu XH, Yue S, Wu HY, Yang J, Fan XS, Fu Y, Ye Q, Chen J, 2020
Sonic Hedgehog stimulates migration of MCF-7 breast cancer cells through Rac1., Shen T, Han B, Leng Y, Yan S, Shi JF, Yue S, Cheng SY, 2019
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling., Liu X, Shen Q, Yu T, Huang H, Zhang Z, Ding J, Tang Y, Xu N, Yue S, 2016
Requirement of Smurf-mediated Endocytosis of Patched1 in Sonic Hedgehog Signal Reception., Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY, 2014
Dual phosphorylation of Suppressor of fused by PKA and GSK3beta regulates its stability and localization in the primary cilium., Chen Y, Yue S, Xie L, Pu XH, Jin T, Cheng SY, 2011
Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway., Yue S, Chen Y, Cheng SY, 2009

Tumor Cells Molecular Regulation Medulloblastoma Pediatric Cancer Post-Translational Modification Signal Transduction Protein Modification Cancer Research Cellular Mechanisms Oncology

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