Professor | Shuhua Chen | Asia Growth Partners

Name	Shuhua Chen
Contact Information	shuhuachen@csu.edu.cn
Language ability	Chinese, English
Province	Hunan

Name

Shuhua Chen

Contact Information

shuhuachen@csu.edu.cn

Language ability

Chinese, English

Province

Hunan

University/Lab Affiliation and Title	Central South University
Faculty	Life Sciences
Academic Background & Achievements	2012 - PhD in Pathophysiology from Central South University Postdoctoral research at University of Pittsburgh School of Medicine (2013-2015) Led 2 national natural science funds, 2 key R&D plan projects in Hunan, and other provincial projects
Work Experience	2013-2015 - University of Pittsburgh School of Medicine, Postdoctoral Researcher Current - Central South University, Professor and Vice Director of the Department of Biochemistry and Molecular Biology
Awards	Second Prize in Natural Science of Hunan Province (3rd place) Second Prize for Excellent Academic Paper in Natural Science of Hunan Province (1st place)

University/Lab Affiliation and Title

Central South University

Faculty

Life Sciences

Academic Background & Achievements

2012 - PhD in Pathophysiology from Central South University
Postdoctoral research at University of Pittsburgh School of Medicine (2013-2015)
Led 2 national natural science funds, 2 key R&D plan projects in Hunan, and other provincial projects

Work Experience

2013-2015 - University of Pittsburgh School of Medicine, Postdoctoral Researcher
Current - Central South University, Professor and Vice Director of the Department of Biochemistry and Molecular Biology

Awards

Second Prize in Natural Science of Hunan Province (3rd place)
Second Prize for Excellent Academic Paper in Natural Science of Hunan Province (1st place)

Areas of Focus	Vascular and metabolic disease mechanisms Inflammation and immunity
Publications	Research progress of endothelial-mesenchymal transition in diabetic kidney disease, Chen S, 2022 Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow, Chen S, 2022 LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis, Chen S, 2021 Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission, Chen S, 2019 S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1, Chen S, 2019 Palmitic acid-induced autophagy increases reactive oxygen species via the Ca2+/PKCα/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells, Chen S, 2019 TWEAK/Fn14 promotes oxidative stress through AMPK/PGC‑1α/MnSOD signaling pathway in endothelial cells, Chen S*, 2018 NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock, Chen S, 2017 Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction, Chen S, 2015 Severe multiple organ injury in HSF1 knockout mice induced by lipopolysaccharide is associated with an increase in neutrophil infiltration and surface expression of adhesion molecules, Chen S, 2012

Areas of Focus

Vascular and metabolic disease mechanisms
Inflammation and immunity

Publications

Research progress of endothelial-mesenchymal transition in diabetic kidney disease, Chen S*, 2022
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow, Chen S*, 2022
LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis, Chen S*, 2021
Vildagliptin improves high glucose-induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission, Chen S*, 2019
S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1, Chen S*, 2019
Palmitic acid-induced autophagy increases reactive oxygen species via the Ca2+/PKCα/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells, Chen S*, 2019
TWEAK/Fn14 promotes oxidative stress through AMPK/PGC‑1α/MnSOD signaling pathway in endothelial cells, Chen S*, 2018
NK1.1+ cells promote sustained tissue injury and inflammation after trauma with hemorrhagic shock, Chen S, 2017
Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction, Chen S, 2015
Severe multiple organ injury in HSF1 knockout mice induced by lipopolysaccharide is associated with an increase in neutrophil infiltration and surface expression of adhesion molecules, Chen S, 2012

Vascular Diseases Metabolic Disorders Pathogenesis Endothelial Dysfunction Diabetes Atherosclerosis Immune Response Inflammatory Diseases Cell Signaling Molecular Biology

Shuhua Chen - Central South University

Shui Wang - Shanghai Normal University

Yingxin Qi - Shanghai Jiao Tong University

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