Current - Southern Medical University - Dean of the School of Basic Medical Sciences
Current - Guangdong Key Laboratory of Degenerative Bone and Joint Diseases - Director
National Science and Technology Progress Award Second Prize (2016): Mechanism and clinical prevention and treatment of chronic kidney disease
Chinese Medical Science and Technology Award First Prize (2021): Innovation and application of treatment strategies and key technologies for degenerative bone and joint diseases
Yunnan Provincial Natural Science First Prize (2018): Signal network regulation mechanism and intervention strategies for primary osteoporosis
Guangdong Provincial Science and Technology Progress Second Prize (2011): Research on the regulatory mechanism and significance of several key signal pathways in cell proliferation and differentiation
Guangdong City Science and Technology Progress First Prize (2011): Research on the regulatory mechanism and significance of several key signal pathways in cell proliferation and differentiation
Guangdong Provincial Education and Teaching Achievement Award First Prize (2022): Construction and practice of a training system for top-notch talents in basic medicine
Ministry of Education 2021 Basic Discipline Top-notch Student Training Program 2.0 Excellent Management Personnel Award (2022)
Research
Bone biology Cell metabolism Signal transduction Osteoarthritis Osteoporosis Bone and cartilage regeneration and repair Bone biomaterials
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration., Wei X, Qiu J, Lai R, Wei T, Lin Z, Huang S, Jiang Y, Kuang Z, Zeng H, Gong Y, Xie X, Yang J, Zhang Y, Zhang S, Zou Z, Gao X*, Bai X*., 2024
Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients., Xie J, Liu X, Wu B, Chen B, Song Q, Guan Y, Gong Y, Yang C, Lin J, Huang M, Tan X, Lai R, Lin X, Zhang S, Xie X, Chen X, Zhang C, Yang M, Nong H, Zhao X, Xia L, Zhou W, Xiao G, Jiang Q, Zou W, Chen D, Lu D*, Liu J*, Bai X*., 2024
An integrated multi-omics analysis reveals osteokines involved in global regulation., Liang W, Wei T, Hu L, Chen M, Tong L, Zhou W, Duan X, Zhao X, Zhou W, Jiang Q, Xiao G, Zou W, Chen D*, Zou Z*, Bai X*., 2024
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation., Hu H, Luo S, Lai P, Lai M, Mao L, Zhang S, Jiang Y, Wen J, Zhou W, Liu X, Wang L, Huang M, Hu Y, Zhao X, Xia L, Zhou W, Jiang Y, Zou Z, Liu A*, Guo B*, Bai X*., 2024
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation., Hu Z, Xie Y, Lu J, Yang J, Zhang J, Jiang H, Li H, Zhang Y, Wu D, Zeng K, Bai X, Yu X., 2023
TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice., Xie X, Zhang W, Xiao M, Wei T, Qiu Y, Qiu J, Wang H, Qiu Z, Zhang S, Pan Y, Mao L, Li Y, Guo B, Yang W, Hu Y, Hu S, Gong Y, Yang J, Xiao G*, Zhang Y*, Bai X*., 2023
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma., Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z*, Bai X*., 2023
Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules., Zou W, Lai M, Jiang Y, Mao L, Zhou W, Zhang S, Lai P, Guo B, Wei T, Nie C, Zheng L, Zhang J, Gao X, Zhao X, Xia L, Zou Z, Liu A, Liu S, Cui ZK*, Bai X*., 2023
Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function., Cao H, Zhong Y, Zhou L, Lin S, Hou X, Ding Z, Li Y, Yao Q, Cao H, Zou X, Chen D, Bai X*, Xiao G*., 2023
FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis., Guo D, Lin C, Lu Y, Guan H, Qi W, Zhang H, Shao Y, Zeng C, Zhang R, Zhang H, Bai X*, Cai D*., 2022
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7., Zhang H, Shao Y, Yao Z, Liu L, Zhang H, Yin J, Xie H, Li K, Lai P, Zeng H, Xiao G, Zeng C*, Cai D*, Bai X*., 2022
Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis., Wu X, Lai Y, Chen S, Zhou C, Tao C, Fu X, Li J, Tong W, Tian H, Shao Z, Liu C, Chen D, Bai X *, Cao H *, Xiao G *., 2022
Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells., Gong Y, Li Z, Zou S, Deng D, Lai P, Hu H, Yao Y, Hu L, Zhang S, Li K, Wei T, Zhao X, Xiao G, Chen Z, Jiang Y, Bai X*, Zou Z*., 2021
Osteocytes regulate neutrophil development through IL-19: A potent cytokine for neutropenia treatment., Xiao M#, Zhang W#, Li W#, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z*, Bai X*., 2021
Tsc1 regulates tight junction independent of mTORC1., Lai M, Zou W, Han Z, Zhou L, Qiu Z, Chen J, Zhang S, Lai P, Li K, Zhang Y, Liang L, Jiang Y, Zou Z*, Bai X*., 2021
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors., Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q*, Bai X*., 2021
Macrophages regulate the progression of osteoarthritis., Zhang H, Cai D*, Bai X*., 2020
Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12., Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, Wang H, Shao Y , Zhang H, Zhang R, Zhao C, Fang H, Cai D*, Bai X*., 2019
Citrate‐Based Tannin‐Bridged Bone Composites for Lumbar Fusion., Guo J, Tian X, Xie D, Rahn K, Gerhard E, Kuzma M, Zhou D, Dong C, Bai X*, Lu Z*, Yang J*., 2019
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2., Zhang H, Lin C, Zeng C, Wang Z, Wang H, Lu J, Liu X, Shao Y, Zhao C, Pan J, Xu S, Zhang Y, Xie D, Cai D*, Bai X*., 2018
Tyrosine kinase Fyn promotes osteoarthritis by activating the β-catenin pathway., Li K, Zhang Y, Zhang Y, Jiang W, Shen J, Xu S, Cai D, Shen J, Huang B, Li M, Song Q, Jiang Y, Liu A, Bai X*., 2018
Exosome Release Is Regulated by mTORC1., Zou W, Lai M, Zhang Y, Zheng, Xing Z, Li T, Zou Z, Song Q,Zhao X, Xia L, Yang J, Liu A,Zhang H, Cui Z*, Jiang Y*, Bai X*., 2018
Citrate-based materials fuel human stem cells by metabonegenic regulation., Ma C, Tian X, Kim JP, Xie D, Ao X, Shan D, Lin Q, Hudock MR, Bai X*, Yang J*., 2018
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42., Xu S, Zhang Y, Wang J, Li K, Tan K, Liang K, Shen J, Cai D, Jin D, Li M, Xiao G, Xu J, Jiang Y, Bai X*., 2018
Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice., Lu J, Zhang H, Cai D, Zeng C, Lai P, Shao Y, Fang H, Li D, Ouyang J, Zhao C, Xie D, Huang B, Yang J, Jiang Y, Bai X*., 2018
Osteoblasts support megakaryopoiesis through production of interleukin-9., Xiao M, Wang Y, Tao C, Wang Z, Yang J, Chen Z, Zou Z, Li M, Liu A, Jia C, Huang B, Yan B, Lai P, Ding C, Cai D, Xiao G, Jiang Y, Bai X*., 2017
Neuronal mTORC1 is required for maintaining the nonreactive state of astrocytes., Zhang Y, Xu S, Liang KY, Li K, Zou ZP, Yang CL, Tan K, Cao X, Jiang Y, Gao TM, Bai XC*., 2017
Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone., Huang B, Wang W, Li Q, Wang Z , Yan B, Zhang Z, Wang L , Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D*, Bai X*., 2016
mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation., Yang J, Zhou X, Fan X, Xiao M, Yang D, Liang B, Dai M, Shan L, Lu J, Lin Z, Liu R, Liu J, Wang L, Zhong M, Jiang Y, Bai X*., 2016
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation., Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, Wang T, Li S, Zhang H, Huang B, Lai P, Wang H, Liu A, Zeng C, Cai D, Jiang Y, Bai X*., 2016
mTORC2 promotes cell survival through c-Myc-dependent up-regulation of E2F1., Zou Z, Chen J, Liu A, Zhou X, Song Q, Jia C, Chen Z, Lin J, Yang C, Li M, Jiang Y, Bai X*., 2015
mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway., Huang B, Wang Y, Wang W, Chen J, Lai P, Liu Z, Yan B, Xu S, Zhang Z, Zeng C, Rong L, Liu B, Cai D, Jin D, Bai X*., 2015
Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure., Chen Z, Kang X, Wang L, Dong H, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Zhang W, Yuan W, Zhong M, Du H*, Bai X*., 2015
Enhancement of the synthesis of n-3 PUFAs in fat-1 transgenic mice inhibits mTORC1 signalling and delays surgically induced osteoarthritis in comparison with wild-type mice., Huang MJ, Wang L, Jin DD, Zhang ZM, Chen TY, Jia CH, Wang Y, Zhen XC, Huang B, Yan B, Chen YH, Li SF, Yang JC, Dai YF, Bai XC*., 2014
Activation of mTORC1 in collecting ducts causes hyperkalemia., Chen Z, Dong H, Jia C, Song Q, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Liu M, Lin J, Yang C, Li M, Gao T, Bai X*., 2014
miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM., Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X*., 2014
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression., Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y*, Bai X*., 2014
IKK-β mediates hydrogen peroxide induced cell death through p85 S6K1., Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang CL, Gao TM, Jiang Y, Bai X*., 2013
Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis., Wen ZH, Su YC, Lai PL, Zhang Y, Xu YF, Zhao A, Yao GY, Jia CH, Lin J, Xu S, Wang L, Wang XK, Liu AL, Jiang Y, Dai YF*, Bai X*., 2013
Key factors in mTOR regulation., Bai X*, Jiang Y*., 2010
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38., Bai X, Ma DZ, Liu AL, Shen XY, Wang QM, Liu YJ, Jiang Y*., 2007
Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast., Bai X*, Lu D, Liu AL, Zhang ZM, Li XM, Zou ZP, Zeng WS, Cheng BL, Luo SQ., 2005
Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB., Bai XC, Lu D, Bai J, Zheng H, Ke ZY, Li XM, Luo SQ*., 2004
